Impaired Oxygen-dependent Reduction of HIF-1α and -2α Proteins in Pre-eclamptic Placentae

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

The Pathology of the Human Placenta

1967 • 2,145 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

2002 • 1,512 citations

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

2002 • 1,472 citations

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2001 • 1,326 citations

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

2001 • 1,230 citations

Onset of Maternal Arterial Blood Flow and Placental Oxidative Stress

2000 • 1,009 citations

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

2001 • 994 citations

Regulation of Human Placental Development by Oxygen Tension

1997 • 905 citations

The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1998 • 761 citations

HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

2001 • 748 citations

Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy.

1992 • 747 citations

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1993 • 740 citations

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

2001 • 666 citations

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

1999 • 645 citations

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

2000 • 615 citations

Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells

2000 • 592 citations

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

1998 • 572 citations

Oxygen and placental villous development: Origins of fetal hypoxia

1997 • 563 citations

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT

1998 • 561 citations

Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia.

1996 • 560 citations

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

1997 • 526 citations

Placental Cytokines and the Pathogenesis of Preeclampsia

1997 • 476 citations

Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia.

1997 • 402 citations

Oxygen and Placental Development During the First Trimester: Implications for the Pathophysiology of Pre-eclampsia

2000 • 372 citations

Inhibition of TGF-β3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies

1999 • 363 citations

Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast

1997 • 331 citations

Expression of Inflammatory Cytokines in Placentas from Women with Preeclampsia¹

2001 • 326 citations

Expression and Characterization of Hypoxia-Inducible Factor (HIF)-3α in Human Kidney: Suppression of HIF-Mediated Gene Expression by HIF-3α

2001 • 267 citations

Hypoxia Stimulates Cytokine Production by Villous Explants from the Human Placenta¹

1997 • 253 citations

Effect of hypoxia on trophoblast in organ culture

1970 • 241 citations

Expression, Ontogeny, and Regulation of Hypoxia-Inducible Transcription Factors in the Human Placenta1

2000 • 172 citations

Placental expression of vascular endothelial growth factor in placentae from pregnancies complicated by pre-eclampsia and intrauterine growth restriction does not support placental hypoxia at delivery

1997 • 156 citations

Selective Overexpression of the Hypoxia-Inducible Transcription Factor, HIF-2α, in Placentas from Women with Preeclampsia1

2001 • 153 citations

VEGF mRNA levels in placentae from pregnancies complicated by pre‐eclampsia

1996 • 152 citations

Accommodation of the human placenta to hypoxia

1966 • 144 citations

HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradation

2001 • 138 citations

Immunolocalization of tumour necrosis factor-α (TNF-α) in the placental bed of normotensive and hypertensive human pregnancies

1998 • 119 citations

Angiogenesis and the placental environment

1995 • 112 citations

Systemic hemodynamics and oxygen transport during pregnancy in chronically instrumented, conscious rats

1992 • 105 citations

THE VILLOUS CYTOTROPHOBLAST AS AN INDEX OF PLACENTAL ISCHAEMIA

1964 • 99 citations

Villous trophoblast of human placenta: a coherent view of its turnover, repair and contributions to villous development and maturation.

2001 • 99 citations

Influence of hypoxia on vascular endothelial growth factor and chorionic gonadotrophin production in the trophoblast-derived cell lines: JEG, JAr and BeWo

1997 • 82 citations

Interaction of interstitial trophoblast with placental bed capillaries and venules of normotensive and pre-eclamptic pregnancies

1998 • 76 citations

Increased depth of trophoblast invasion after chronic constriction of the lower aorta in rhesus monkeys

1993 • 68 citations