Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

The determination of enzyme inhibitor constants

1953 • 4,050 citations

[1] Measurement of molecular weights by electrophoresis on SDS-acrylamide gel

1972 • 1,733 citations

[117] Chromatographic determination of amino acids by the use of automatic recording equipment

1963 • 1,683 citations

Renin-angiotensin system: biochemistry and mechanisms of action.

1977 • 1,373 citations

Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.

1983 • 374 citations

Collagenases

1974 • 303 citations

Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e

1978 • 271 citations

An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides

1984 • 249 citations

Crystallographic study of the binding of dipeptide inhibitors to thermolysin: implications for the mechanism of catalysis

1977 • 240 citations

Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis

1981 • 231 citations

A THERMOLYSIN INHIBITOR PRODUCED BY ACTINOMYCETES: PHOSPHORAMIDON

1973 • 185 citations

Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by x-ray crystallography: a novel class of transition-state analogs for zinc peptidases

1984 • 153 citations

Carboxypeptidase A. Differences in the mechanisms of ester and peptide hydrolysis

1974 • 148 citations

Isolation and characterization of a proteolytic enzyme from the venom of the snake Bothrops jararaca (Jararaca)

1982 • 143 citations

Evaluation and propagation of confidence intervals in nonlinear, asymmetrical variance spaces. Analysis of ligand-binding data

1983 • 141 citations

Inhibition of thermolysin and carboxypeptidase A by phosphoramidates

1979 • 138 citations

Solid phase peptide synthesis

2022 • 124 citations

Peptide hydroxamic acids as inhibitors of thermolysin

1978 • 116 citations

Kallikrein-like enzymes from Crotalus atrox venom.

1983 • 93 citations

Anticoagulant proteases from western diamondback rattlesnake (Crotalus atrox) venom

1984 • 86 citations

Isolation and characterization of a hemorrhagic proteinase from timber rattlesnake venom

1983 • 83 citations

Fibrinolytic enzyme(s) in western diamondback rattlesnake (Crotalus atrox) venom

1980 • 82 citations

Metal-coordinating substrate analogs as inhibitors of metalloenzymes.

1979 • 81 citations

Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox)

1983 • 79 citations

Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom

1983 • 73 citations

Investigation of snake venom enzymes I. Separation of rattlesnake venom proteinases by cellulose ion-exchange chromatography

1961 • 62 citations

Inhibition of thermolysin by N-carboxymethyl dipeptides

1981 • 56 citations

Active site directed irreversible inhibition of thermolysin

1978 • 50 citations

Structural analysis of the inhibition of thermolysin by an active-site-directed irreversible inhibitor

1983 • 49 citations

Binding of the biproduct analog L-benzylsuccinic acid to thermolysin determined by X-ray crystallography.

1979 • 42 citations

Mechanism of action of thrombin on fibrinogen

1977 • 40 citations

Reactivity of bovine blood coagulation factor IXa.beta., factor Xa.beta., and factor XIa toward fluorogenic peptides containing the activation site sequences of bovine factor IX and factor X

1983 • 34 citations

Presence of zinc in proteolytic hemorrhagic toxin isolated from Agkistrodon acutus venom

1982 • 31 citations

Zur Evolution der Endopeptidasen, II. Eigenschaften der α-Protease aus dem Gift vonCrotalus atrox

1967 • 29 citations

Effect of calcium on proteolytic activity and conformation of hemorrhagic toxin I from five pace snake (Agkistrodon acutus) venom

1984 • 27 citations

Purification, characterization and analysis of the mechanism of action of four anti-complementary factors in Crotalus atrox venom

1977 • 23 citations

Application of Crotalus atrox venom α-protease for amino acid sequence determination

1967 • 21 citations

Isolation and identification of a collagenolytic enzyme from the venom of the western diamondback rattlesnake (Crotalus atrox)

1982 • 15 citations

New Proteases from Crotalus Atrox Venom

1983 • 7 citations

[1] Synthesis and use of neuropeptides

1983 • 5 citations