Prevention and slowing down the progression of the diabetic nephropathy through antihypertensive therapy

Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study

1995 • 3,109 citations

Insulin Resistance in Essential Hypertension

1987 • 2,386 citations

The Effects of Dietary Protein Restriction and Blood-Pressure Control on the Progression of Chronic Renal Disease

1994 • 2,274 citations

Microalbuminuria Predicts Clinical Proteinuria and Early Mortality in Maturity-Onset Diabetes

1984 • 1,939 citations

MICROALBUMINURIA AS A PREDICTOR OF CLINICAL NEPHROPATHY IN INSULIN-DEPENDENT DIABETES MELLITUS

1982 • 1,683 citations

The Effect of Long-Term Intensified Insulin Treatment on the Development of Microvascular Complications of Diabetes Mellitus

1993 • 1,215 citations

Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat.

1986 • 1,071 citations

National High Blood Pressure Education Program Working Group report on hypertension in diabetes.

1994 • 1,036 citations

Nonenzymatic Glycosylation and the Pathogenesis of Diabetic Complications

1984 • 1,012 citations

Familial Clustering of Diabetic Kidney Disease

1989 • 991 citations

The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy

1983 • 940 citations

EARLY AGGRESSIVE ANTIHYPERTENSIVE TREATMENT REDUCES RATE OF DECLINE IN KIDNEY FUNCTION IN DIABETIC NEPHROPATHY

1983 • 884 citations

The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies

1982 • 807 citations

Long-Term Stabilizing Effect of Angiotensin-Converting Enzyme Inhibition on Plasma Creatinine and on Proteinuria in Normotensive Type II Diabetic Patients

1993 • 795 citations

Long-term antihypertensive treatment inhibiting progression of diabetic nephropathy

1982 • 772 citations

FACTOR-VIII COMPLEX AND ENDOTHELIAL DAMAGE

1975 • 717 citations

Predisposition to Hypertension and Susceptibility to Renal Disease in Insulin-Dependent Diabetes Mellitus

1988 • 650 citations

Effect of Antihypertensive Therapy on the Kidney in Patients with Diabetes: A Meta-Regression Analysis

1993 • 612 citations

Proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus.

1987 • 565 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. European Microalbuminuria Captopril Study Group

1994 • 494 citations

Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria.

1991 • 478 citations

Renal protective effect of enalapril in diabetic nephropathy.

1992 • 437 citations

Effect of Captopril on Heavy Proteinuria in Azotemic Diabetics

1985 • 430 citations

Sustained expression of TGF-β1 underlies development of progressive kidney fibrosis

1994 • 413 citations

Effect of Restricting Dietary Protein on the Progression of Renal Failure in Patients with Insulin-Dependent Diabetes Mellitus

1991 • 411 citations

Familial predisposition to renal disease in two generations of Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus

1990 • 393 citations

Transforming growth factor-β regulates production of proteoglycans by mesangial cells

1990 • 365 citations

Relationships Between Angiotensin I Converting Enzyme Gene Polymorphism, Plasma Levels, and Diabetic Retinal and Renal Complications

1994 • 361 citations

Increased Sodium-Lithium Countertransport Activity in Red Cells of Patients with Insulin-Dependent Diabetes and Nephropathy

1988 • 348 citations

Microvascular and acute complications in IDDM patients: the EURODIAB IDDM Complications Study

1994 • 347 citations

Smoking Is Associated With Progression of Diabetic Nephropathy

1994 • 294 citations

Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat.

1992 • 270 citations

Similar Risks of Nephropathy in Patients with Type I or Type II Diabetes Mellitus

1989 • 254 citations

GLUCOSE INTOLERANCE IN HYPERTENSIVE PATIENTS TREATED WITH DIURETICS; A FOURTEEN-YEAR FOLLOW-UP

1982 • 244 citations

RESTRICTION OF DIETARY PROTEIN AND PROGRESSION OF RENAL FAILURE IN DIABETIC NEPHROPATHY

1989 • 231 citations

DIABETIC NEPHROPATHY

1959 • 231 citations

Treatment of arterial hypertension in diabetic humans: Importance of therapeutic selection

1992 • 227 citations

Comparison between perindopril and nifedipine in hypertensive and normotensive diabetic patients with microalbuminuria

1991 • 226 citations

Effects of Antihypertensive Treatment on Insulin Sensitivity With Special Reference to ACE Inhibitors

1991 • 216 citations

Diabetic control and microvascular complications: The near-normoglycaemic experience

1986 • 202 citations

Reduction in albuminuria predicts a beneficial effect on diminishing the progression of human diabetic nephropathy during antihypertensive treatment

1994 • 195 citations

Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes

1996 • 194 citations

Comparison between perindopril and nifedipine in hypertensive and normotensive diabetic patients with microalbuminuria. Melbourne Diabetic Nephropathy Study Group.

1991 • 193 citations

Association of ACE gene polymorphism and diabetic nephropathy?

1995 • 180 citations

Effects of Diltiazem or Lisinopril on Massive Proteinuria Associated with Diabetes Mellitus

1990 • 167 citations

Postprandial hyperinsulinemia in patients with mild essential hypertension.

1985 • 166 citations

Captopril reduces the risk of nephropathy in IDDM patients with microalbuminuria

1996 • 159 citations

Captopril reduces the risk of nephropathy in IDDM patients with microalbuminuria

1996 • 155 citations

The course of kidney function in Type 2 (non-insulin-dependent) diabetic patients with diabetic nephropathy

1993 • 154 citations

Is screening and intervention for microalbuminuria worthwhile in patients with insulin dependent diabetes?

1993 • 153 citations

Rising Incidence of IDDM in Europe

1989 • 149 citations

Blood pressure and metabolic control as risk factors for nephropathy in Type 1 (insulin-dependent) diabetes

1985 • 147 citations

Nephroprotective Effects of Nitrendipine in Hypertensive Tune I and Type II Diabetic Patients

1993 • 147 citations

Comparative Effects of Different Antihypertensive Treatments on Progression of Diabetic Renal Disease

1993 • 142 citations

Therapeutic efficacy of different antihypertensive drugs in human diabetic nephropathy: an updated meta-analysis.

1995 • 141 citations

Comparison of enalapril and nifedipine in treating non-insulin dependent diabetes associated with hypertension: one year analysis.

1992 • 138 citations

Short-term antiproteinuric response to antihypertensive treatment predicts long-term GFR decline in patients with non-diabetic renal disease.

1994 • 137 citations

Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator

1995 • 136 citations

Risk factors for development of microalbuminuria in insulin dependent diabetic patients: a cohort study. Microalbuminuria Collaborative Study Group, United Kingdom.

1993 • 134 citations

Excess Mortality and Its Relation toHypertension and Proteinuria in Diabetic Patients

1996 • 126 citations

Calcium antagonists and converting enzyme inhibitors reduce renal injury by different mechanisms

1993 • 115 citations

Comparative Study of the Effect of ACE-Inhibitors and Other Antihypertensive Agents on Proteinuria in Diabetic Patients

1994 • 114 citations

Microalbuminuria in Patients With NIDDM: An Overview

1996 • 111 citations

Role of advanced glycosylation products in complications of diabetes.

1988 • 107 citations

An Economic Analysis of Captopril in the Treatment of Diabetic Nephropathy

1996 • 106 citations

The Predictive Value of Microalbuminuriq in IPPM: A five-year follow-up study

1994 • 106 citations

Increased blood pressure and erythrocyte sodium/lithium countertransport activity are not inherited in diabetic nephropathy

1990 • 103 citations

The rising tide of endstage renal failure from diabetic nephropathy type II—an epidemiological analysis

1995 • 103 citations

Dietary protein restriction rapidly reduces transforming growth factor beta 1 expression in experimental glomerulonephritis.

1991 • 96 citations

UK PROSPECTIVE DIABETES STUDY (UKPDS) .11. BIOCHEMICAL RISK-FACTORS IN TYPE-2 DIABETIC-PATIENTS AT DIAGNOSIS COMPARED WITH AGE-MATCHED NORMAL SUBJECTS

1994 • 90 citations

Serum Lipoproteins During Treatment with Antihypertensive Drugs

1988 • 90 citations

Relationships between angiotensin I converting enzyme gene polymorphism, plasma levels, and diabetic retinal and renal complications

1994 • 86 citations

Hemodynamic, Renal, and Humoral Effects of the Calcium Entry Blocker Nicardipine and Converting Enzyme Inhibitor Captopril in Hypertensive Type II Diabetic Patients with Nephropathy

1989 • 85 citations

Transforming Growth Factor-β1 Enhances Glomerular Collagen Synthesis in Diabetic Rats

1993 • 85 citations

UK Prospective Diabetes Study (UKPDS) XI: Biochemical Risk Factors in Type 2 Diabetic Patients at Diagnosis Compared with Age‐matched Normal Subjects

1994 • 84 citations

Drug Treatment of Hypertension in Patients With Diabetes Mellitus

1991 • 80 citations

Proteinuria—A direct cause of renal morbidity?

1994 • 77 citations

Acute reduction of arterial blood pressure reduces urinary albumin excretion in Type 1 (insulin-dependent) diabetic patients with incipient nephropathy

1986 • 76 citations

Angiotensin-Converting Enzyme Inhibition and Renal Protection

1993 • 72 citations

Effects of glycated albumin on mesangial cells: evidence for a role in diabetic nephropathy

1993 • 70 citations

Effects of Calcium Antagonists on Renal Hemodynamics and Progression of Nondiabetic Chronic Renal Disease

1994 • 68 citations

Long-Term Treatment With Either Enalapril or Nitrendipine Stabilizes Albuminuria and Increases Glomerular Filtration Rate in Non- Insulin-Dependent Diabetic Patients

1994 • 64 citations

Antihypertensive treatment: Long-term reversal of progression of albuminuria in incipient diabetic nephropathy. A longitudinal study of renal function

1987 • 60 citations

Amelioration of proteinuria with pravastatin in hypercholesterolemic patients with diabetes mellitus.

1990 • 59 citations

Systolic Blood Pressure Relates to the Rate of Decline of Glomerular Filtration Rate in Type II Diabetes

1993 • 58 citations

The transforming growth factor-beta system and the kidney.

1993 • 57 citations

Low-protein diet attenuates increased gene expression of platelet-derived growth factor and transforming growth factor-beta in experimental glomerular sclerosis.

1993 • 54 citations

Effects of Angiotensin Converting Enzyme Inhibitors and Calcium Antagonists on Atrial Natriuretic Peptide Release and Action and on Albumin Excretion Rate in Hypertensive Insulin-Dependent Diabetic Patients

1992 • 50 citations

Glomerular volume expansion and mesangial cell mechanical strain: mediators of glomerular pressure injury.

1994 • 50 citations

Arterial hypertension and microalbuminuria in IDDM: The Italian Microalbuminuria Study

1994 • 45 citations

Messenger RNA Expression for Growth Factors in Glomeruli from Focal Glomerular Sclerosis

1993 • 44 citations

INTERCAPILLARY GLOMERULOSCLEROSIS

1939 • 42 citations

Erythrocyte sodium-lithium countertransport is not different in Type 1 (insulin-dependent) diabetic patients with and without diabetic nephropathy

1991 • 37 citations

Hypertension in Diabetic Patients An Overview of Interventional Studies to Preserve Renal Function

1993 • 35 citations

Relationship Between Blood Pressure and Urinary Albumin Excretion Rate in Young Danish Type 1 Diabetic Patients: Comparison to Non‐diabetic Children

1994 • 33 citations

Mechanisms of Diabetic Nephropathy

1994 • 31 citations

A Comparison of Spirapril and Isradipine in Patients with Diabetic Nephropathy and Hypertension

1993 • 30 citations

Long-term reduction of microalbuminuria after 3 years of angiotensin-converting enzyme inhibition by perindopril in hypertensive insulin-treated diabetic patients

1992 • 29 citations

Statement on Hypertension in Diabetes

1987 • 28 citations

Effects of Atenolol and Enalapril on Kidney Function in Hypertensive Diabetic Patients

1993 • 27 citations

Long-term treatment with nifedipine reduces urinary albumin excretion and glomerular filtration rate in normotensive type 1 diabetic patients with microalbuminuria

1994 • 26 citations

Diabetes in Europe

1994 • 25 citations

Efficacy of antihypertensive treatment with indapamide in patients with noninsulin-dependent diabetes and persistent microalbuminuria

1990 • 25 citations

Diabetic Nephropathy: Pathogenesis and Treatment

1993 • 24 citations

Schätzung der Diabeteshäufigkeit in der Bundesrepublik Deutschland anhand von Krankenkassendaten: Sekundärdatenanalyse einer repräsentativen Stichprobe AOK-Versicherter der Stadt Dortmund

2008 • 24 citations

Uncontrolled hypertension is associated with a rapid progression of nephropathy in type 2 diabetic patients with proteinuria and preserved renal function.

1990 • 22 citations

Transforming growth factor-beta 1 enhances glomerular collagen synthesis in diabetic rats

1993 • 20 citations

Effect of Dietary Protein Restriction on Proteinuria in Non-Insulin-Dependent Diabetic Patients with Nephropathy

1991 • 20 citations

Effects of calcium antagonists on renal hemodynamics and progression of nondiabetic chronic renal disease

1994 • 18 citations

Inequalities in health: changes in RHAs in the past decade.

1987 • 17 citations

Comparative effects of different antihypertensive treatments on progression of diabetic renal disease

1993 • 17 citations

Angiotensin-converting enzyme inhibition and renal protection. An assessment of implications for therapy

1993 • 12 citations

Effects of dietary protein restriction on hemodynamics in chronic renal failure

1993 • 7 citations

Hypertension and micro-albuminuria in diabetic patients taking indapamide

1989 • 6 citations

Die diabetische Nephropathie

2004 • 5 citations

The impact of angiotensin converting enzyme inhibitor therapy on renal function in diabetics: results of a meta-analysis.

1995 • 3 citations

[Hypertension, microalbuminuria and insulin resistance in diabetes mellitus].

1994 • 3 citations

Effect of cicletanine on prostacyclin secretion by human endothelial cells in vitro.

1995 • 2 citations

Hypertonie bei Diabetes mellitus

1980 • 2 citations

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