Adeno-Associated Virus-Mediated Gene Transfer to the Brain: Duration and Modulation of Expression

Presidential Address^*

1967 • 1,183 citations

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1994 • 1,032 citations

Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector

1996 • 902 citations

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

1996 • 747 citations

Recombinant adeno-associated virus for muscle directed gene therapy

1997 • 656 citations

From the Cover: Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system

2000 • 607 citations

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

1997 • 588 citations

Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus

1997 • 473 citations

Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector

1996 • 458 citations

Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus

1997 • 399 citations

Towards a neuroprotective gene therapy for Parkinson’s disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model11Published on the World Wide Web on 10 October 2000.

2000 • 341 citations

Review of A stereotaxic atlas of the albino mouse forebrain.

1980 • 312 citations

Biology of Adeno-associated Virus

1996 • 302 citations

Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters

1997 • 294 citations

Adeno-associated virus vectors preferentially transduce cells in S phase.

1994 • 272 citations

Cell Lines for the Production of Recombinant Adeno-Associated Virus

1995 • 250 citations

Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors

1994 • 228 citations

Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integration.

1994 • 223 citations

DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors.

1995 • 220 citations

Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration

1997 • 209 citations

Gene Transfer by Adeno-Associated Virus Vectors into the Central Nervous System

1997 • 203 citations

Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease

2000 • 176 citations

The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice

1996 • 169 citations

Recombinant Adeno-Associated Viral Vectors Mediate Long-Term Transgene Expression in Muscle

1997 • 153 citations

Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells

1995 • 139 citations

Lack of Site-Specific Integration of the Recombinant Adeno-Associated Virus 2 Genomes in Human Cells

1997 • 133 citations

Effects of Gamma Irradiation on the Transduction of Dividing and Nondividing Cells in Brain and Muscle of Rats by Adeno-Associated Virus Vectors

1996 • 128 citations

Inactivation of the Very Strong HCMV Immediate Early Promoter by DNA CpG MethylationIn Vitro

1996 • 118 citations

A stable cell line carrying adenovirus-inducible rep and cap genes allows for infectivity titration of adeno-associated virus vectors.

1996 • 110 citations

The principles of gene therapy for the nervous system

1996 • 90 citations

Gene therapy against an experimental glioma using adeno-associated virus vectors.

1996 • 84 citations

Gene transfer and expression in oligodendrocytes under the control of myelin basic protein transcriptional control region mediated by adeno-associated virus

1998 • 83 citations

Evaluation of recombinant adeno-associated virus as a gene transfer vector for the retina

1997 • 78 citations

Recombinant Adeno-Associated Virus-Mediated Correction of Lysosomal Storage within the Central Nervous System of the Adult Mucopolysaccharidosis Type VII Mouse

2000 • 75 citations

Efficient transduction of human neurons with an adeno-associated virus vector.

1996 • 70 citations

Recombinant Adeno-Associated Virus Vector Expressing Glial Cell Line-Derived Neurotrophic Factor Reduces Ischemia-Induced Damage

2000 • 66 citations

Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABAAα1 containing receptors and increases inferior collicular seizure sensitivity

1997 • 64 citations

Adeno-associated virus-based vectors in gene therapy

2000 • 62 citations

The distribution, excretion and metabolism of hydroxyurea-C14.

1965 • 55 citations

Determination of hydroxyurea in mammalian tissues and blood.

1971 • 54 citations

Brain cell type specificity and gliosis-induced activation of the human cytomegalovirus immediate-early promoter in transgenic mice

1996 • 54 citations

Gene Therapy for Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

2000 • 52 citations

Comparison of promoter strengths on gene delivery into mammalian brain cells using AAV vectors.

1996 • 49 citations

Population pharmacokinetics of hydroxyurea in cancer patients

1995 • 40 citations

Adeno-associated viral vector gene transfer into leptomeningeal xenografts.

1997 • 28 citations

Gene Transfer into the CNS Using Recombinant Adeno-associated Virus: Analysis of Vector DNA Forms Resulting in Sustained Expression

1999 • 25 citations

The place of hydroxyurea in the treatment of primary brain tumors.

1992 • 21 citations

Pharmacokinetics of hydroxyurea in nude mice

1994 • 17 citations

Antisense Inhibition of the Renin–Angiotensin System in Brain and Peripheral Organs

2000 • 7 citations