New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

New folate analogs of the 10-deaza-aminopterin series

1984 • 138 citations

Correlates of folate analog transport, pharmacokinetics and selective antitumor action

1980 • 135 citations

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo.

1981 • 84 citations

The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.

1971 • 80 citations

Steady-state enzyme kinetics with high-affinity substrates or inhibitors. A statistical treatment of dose–response curves

1973 • 73 citations

Kinetic correlates of methotrexate transport and therapeutic responsiveness in murine tumors.

1976 • 64 citations

Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin

1982 • 48 citations

[59] Separation of pteroyl-oligo-γ-l-glutamates by high-performance liquid chromatography

1980 • 47 citations

Differential cell permeability and the basis for selective activity of methotrexate during therapy of the L1210 leukemia.

1973 • 42 citations

Analysis of the cytotoxic determinants for methotrexate (NSC 740): a role for 'free' intracellular drug

1975 • 42 citations

Studies on the Persistence of Methotrexate, Cytosine Arabinoside, and Leucovorin in Serum of Mice<xref ref-type="fn" rid="FN2">2</xref>

1969 • 40 citations

Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.

1982 • 40 citations

Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors.

1975 • 38 citations

Therapeutic relevance of differences in the structural specificity of the transport systems for folate analogs in L1210 tumor cells and in isolated murine intestinal epithelial cells.

1977 • 34 citations

Pharmacokinetic basis for differences in methotrexate sensitivity of normal proliferative tissues in the mouse.

1980 • 31 citations

Synthesis and antifolate activity of 10-deazaminopterin

1974 • 27 citations

10-Propargylaminopterin and alkyl homologs of methotrexate as inhibitors of folate metabolism

1982 • 20 citations

Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice.

1982 • 19 citations

Alterations in the kinetics of methotrexate transport during growth of L1210 murine leukemia cells in culture.

1980 • 17 citations

Phase II study of chlorozotocin in the treatment of advanced colorectal cancer.

1981 • 11 citations

Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice.

1978 • 10 citations