Neurogenic genes and vertebrate neurogenesis

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

Notch Signaling

1995 • 1,282 citations

Expression of a Delta homologue in prospective neurons in the chick

1995 • 1,019 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesis

1995 • 764 citations

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

1994 • 749 citations

The choice of cell fate in the epidermis of Drosophila

1991 • 736 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

1995 • 702 citations

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

1995 • 669 citations

Jagged: A mammalian ligand that activates notch1

1995 • 617 citations

Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins

1994 • 560 citations

The suppressor of hairless protein participates in notch receptor signaling

1994 • 547 citations

Asymmetric segregation of Numb and Prospero during cell division

1995 • 489 citations

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1996 • 481 citations

Disruption of the mouse RBP-Jк gene results in early embryonic death

1995 • 478 citations

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)

1995 • 476 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

1995 • 458 citations

Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc.

1991 • 444 citations

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.

1995 • 430 citations

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor

1993 • 424 citations

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

1993 • 421 citations

Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch

1995 • 409 citations

Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system.

1994 • 395 citations

Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing

1995 • 392 citations

lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans

1994 • 385 citations

Mutations affecting the development of the embryonic zebrafish brain

1996 • 374 citations

The PROSPERO transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila

1996 • 333 citations

A dual function of the Notch gene in Drosophila sensillum development

1990 • 333 citations

Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila

1996 • 331 citations

Asymmetric segregation of the homeodomain protein Prospero duringDrosophila development

1995 • 330 citations

A Chick Homologue ofSerrateand Its Relationship withNotchandDeltaHomologues during Central Neurogenesis

1996 • 323 citations

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

1994 • 318 citations

Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila

1990 • 316 citations

An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye

1993 • 307 citations

Xotch , the Xenopus Homolog of Drosophila Notch

1990 • 303 citations

Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio

1996 • 302 citations

An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells

1994 • 298 citations

Xotch inhibits cell differentiation in the xenopus retina

1995 • 293 citations

The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo

1994 • 283 citations

Cell interactions and gene interactions in peripheral neurogenesis.

1993 • 271 citations

Delta-Notch Signaling and Drosophila Cell Fate Choice

1994 • 268 citations

Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates

1992 • 264 citations

Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila

1994 • 260 citations

Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision

1994 • 254 citations

Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS

1995 • 249 citations

Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development

1993 • 222 citations

Cell cycles and clonal strings during formation of the zebrafish central nervous system

1994 • 221 citations

Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo

1992 • 211 citations

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation

1994 • 209 citations

Early neurogenesis in xenopus: The spatio-temporal pattern of proliferation and cell lineages in the embryonic spinal cord

1989 • 207 citations

Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila

1995 • 206 citations

Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis.

1995 • 198 citations

Notch is required for wingless signaling in the epidermis of Drosophila

1994 • 179 citations

Mode of cell proliferation in the developing mouse neocortex.

1994 • 160 citations

Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins.

1994 • 154 citations

The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells.

1992 • 133 citations

Structure/function studies of lin-12/Notch proteins

1994 • 122 citations

Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats

1993 • 107 citations

Developmental Signalling: Vertebrate ligands for Notch

1995 • 107 citations

The determination of sense organs in Drosophila: effect of the neurogenic mutations in the embryo

1991 • 88 citations

The development of the spinal cord examined by autoradiography

1965 • 80 citations

Neurogenic and proneural genes control cell fate specification in the Drosophila endoderm

1995 • 77 citations

Sequential fates in a single cell are established by the neurogenic cascade in the Malpighian tubules of Drosophila

1994 • 72 citations

Intrinsic and extrinsic factors regulating vertebrate neurogenesis

1995 • 71 citations

Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo

1995 • 71 citations

TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination

1995 • 68 citations

Rules for the production of sensory cells.

1991 • 65 citations

Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins

1995 • 61 citations

A collection of cortical crescents: Asymmetric protein localization in CNS precursor cells

1995 • 33 citations

Falling off the knife edge

1993 • 31 citations