Epitope Specificity and Inactivation Mechanisms of Factor VIII Inhibitor Antibodies

Molecular cloning of a cDNA encoding human antihaemophilic factor

1984 • 937 citations

Expression of active human factor VIII from recombinant DNA clones

1984 • 699 citations

The role of phospholipid and factor VIIIa in the activation of bovine factor X.

1981 • 590 citations

Acquired inhibitors of blood coagulation.

1972 • 531 citations

A More Uniform Measurement of Factor VIII Inhibitors

1975 • 498 citations

New variant of von Willebrand disease with defective binding to factor VIII

1989 • 234 citations

A Factor VIII Neutralizing Monoclonal Antibody and a Human Inhibitor Alloantibody Recognizing Epitopes in the C2 Domain Inhibit Factor VIII Binding to von Willebrand Factor and to Phosphatidylserine

1993 • 199 citations

The Acidic Region of the Factor VIII Light Chain and the C2 Domain Together Form the High Affinity Binding Site for von Willebrand Factor

1997 • 196 citations

A role for the C2 domain of factor VIII in binding to von Willebrand factor

1994 • 192 citations

Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site

1995 • 181 citations

Slowed Release of Thrombin-cleaved Factor VIII from von Willebrand Factor by a Monoclonal and a Human Antibody Is a Novel Mechanism for Factor VIII Inhibition

1996 • 175 citations

Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII.

1994 • 175 citations

The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII.

1991 • 159 citations

The Sequence Glu1811-Lys1818 of Human Blood Coagulation Factor VIII Comprises a Binding Site for Activated Factor IX

1996 • 159 citations

Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction

1993 • 155 citations

Factor VIIIa A2 subunit residues 558-565 represent a factor IXa interactive site.

1994 • 150 citations

Residues 484-508 Contain a Major Determinant of the Inhibitory Epitope in the A2 Domain of Human Factor VIII

1995 • 137 citations

Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralization

1989 • 130 citations

von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation

1991 • 125 citations

Epitope mapping of human factor VIII inhibitor antibodies by deletion analysis of factor VIII fragments expressed in Escherichia coli.

1988 • 122 citations

Localization of a Factor X Interactive Site in the A1 Subunit of Factor VIIIa

1997 • 99 citations

A Mechanism for Inhibition of Factor VIII Binding to Phospholipid by von Willebrand Factor

1995 • 97 citations

The functional domains of coagulation factor VIII:C.

1986 • 87 citations

Inhibition of human factor VIIIa by anti-A2 subunit antibodies.

1994 • 83 citations

The incidence of factor VIII inhibitors in patients with severe hemophilia A

1995 • 71 citations

Use of porcine factor VIII for surgical procedures in hemophilia A patients with inhibitors.

1993 • 55 citations

The cDNA and derived amino acid sequence of porcine factor VIII

1996 • 48 citations

Elimination of a major inhibitor epitope in factor VIII.

1994 • 45 citations