Binding of receptor for advanced glycation end products (RAGE) ligands is not sufficient to induce inflammatory signals: lack of activity of endotoxin-free albumin-derived advanced glycation end products

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

1990 • 9,412 citations

RAGE Mediates a Novel Proinflammatory Axis

1999 • 1,807 citations

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

1992 • 1,488 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line

1992 • 1,258 citations

Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE

2001 • 1,017 citations

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

1995 • 886 citations

N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression

1999 • 848 citations

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

1993 • 764 citations

Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.

1997 • 701 citations

Diabetes and advanced glycation endproducts

2002 • 693 citations

AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept

1998 • 547 citations

Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE

2002 • 525 citations

N.epsilon.-(Carboxymethyl)lysine Is a Dominant Advanced Glycation End Product (AGE) Antigen in Tissue Proteins

1995 • 518 citations

The missing link: A single unifying mechanism for diabetic complications

2000 • 517 citations

Advanced Glycation End Product-Induced Activation of NF-κB is Suppressed by α-Lipoic Acid in Cultured Endothelial Cells

1997 • 372 citations

Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor.

1992 • 353 citations

Adhesion molecules and their role in vascular disease

2001 • 348 citations

Age-related accumulation of Maillard reaction products in human articular cartilage collagen

2000 • 314 citations

RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

2002 • 298 citations

Age-dependent accumulation of N.epsilon.-(carboxymethyl)lysine and N.epsilon.-(carboxymethyl)hydroxylysine in human skin collagen

1991 • 298 citations

The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis.

1996 • 286 citations

Do atherosclerosis and type 2 diabetes share a common inflammatory basis?

2002 • 211 citations

Advanced glycation end product ligands for the receptor for advanced glycation end products: biochemical characterization and formation kinetics

2003 • 178 citations

RAGE: A New Target for the Prevention and Treatment of the Vascular and Inflammatory Complications of Diabetes

2000 • 168 citations

AGEs bind to mesothelial cells via RAGE and stimulate VCAM-1 expression

2002 • 155 citations

The collagenous domains of macrophage scavenger receptors and complement component C1q mediate their similar, but not identical, binding specificities for polyanionic ligands.

1993 • 150 citations

Iron activates NF-κB in Kupffer cells

2002 • 116 citations

Characterization of the Advanced Glycation End-Product Receptor Complex in Human Vascular Endothelial Cells

1999 • 107 citations

Age-related accumulation of Maillard reaction products in human articular cartilage collagen

2000 • 104 citations

Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells

1997 • 103 citations

2‐Isopropylidenehydrazono‐4‐oxo‐thiazolidin‐5‐ylacetanilide (OPB‐9195) treatment inhibits the development of intimal thickening after balloon injury of rat carotid artery: role of glycoxidation and lipoxidation reactions in vascular tissue damage

1999 • 84 citations

Blood Glucose Control and Microvascular and Macrovascular Complications in Diabetes

1997 • 75 citations

Endothelial Dysfunction in Diabetes Mellitus

2000 • 71 citations

Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-κB activation

2002 • 67 citations

Diabetes and Advanced Glycation End Products

2003 • 55 citations

Blood Vessel Wall Interactions in Diabetes

1997 • 32 citations

Radioreceptor Assay for Advanced Glycosylation End Products

1991 • 30 citations

Effect of advanced glycation end products on oxidative stress in endothelial cells in culture: a warning on the use of cells studied in serum-free media

2001 • 28 citations

Radioreceptor assay for advanced glycosylation end products

1991 • 12 citations

Effect of Advanced Glycosylation End Products on the Activity of Integrins Expressed on U937 Cells

1998 • 5 citations