The endothelin A receptor antagonist LU 135252 protects the myocardium from neutrophil injury during ischaemia/reperfusion

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

1994 • 1,631 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis

1991 • 967 citations

Role of Neutrophils in Myocardial Ischemia and Reperfusion

1995 • 431 citations

Effect of endothelin-1 on neutrophil adhesion to endothelial cells and perfused heart.

1993 • 198 citations

Contribution of endogenous endothelin to the extension of myocardial infarct size in rats.

1991 • 197 citations

The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes

1991 • 194 citations

The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion

1993 • 153 citations

Adrian Edmund Gill (1937–1986)

1986 • 152 citations

Nitric Oxide Attenuates Neutrophil-Mediated Myocardial Contractile Dysfunction After Ischemia and Reperfusion

1996 • 143 citations

Increased In Vivo Expression and Production of Endothelin-1 by Porcine Cardiomyocytes Subjected to Ischemia

1995 • 122 citations

Endothelin-1 enhances superoxide generation of human neutrophils stimulated by the chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine

1990 • 115 citations

Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Evidence for plasma-mediated leukocyte activation.

1993 • 94 citations

Potent selective vasoconstrictor effects of endothelin in the pig kidneyin vivo

1998 • 93 citations

Lethal ischemia due to intracoronary endothelin in pigs

1989 • 89 citations

Protective effects of non-peptide endothelin receptor antagonist bosentan on myocardial ischaemic and reperfusion injury in the pig

1995 • 81 citations

Aggregation of human polymorphonuclear leukocytes by endothelin: role of platelet-activating factor

1992 • 74 citations

Endothelin-induced activation of neutrophil migration

1994 • 66 citations

The effects of the endothelin ET_A receptor antagonist, FR 139317, on infarct size in a rabbit model of acute myocardial ischaemia and reperfusion

1994 • 57 citations

ICAM-1 Expression on Cardiac Myocytes and Aortic Endothelial Cells via Their Specific Endothelin Receptor Subtype

1996 • 54 citations

[44] Human neutrophil degranulation

1988 • 52 citations

Characterization of endothelins as chemoattractants for human neutrophils

1994 • 36 citations

Characterization of endothelin-1-induced vascular effects in the rat heart by using endothelin receptor antagonists

1994 • 34 citations

Intravenous administration of the endothelin-1 antagonist BQ-123 does not ameliorate myocardial ischaemic injury following acute coronary artery occlusion in the dog

1994 • 34 citations

Inhibition by L-arginine of the endothelin-mediated increase in cytosolic calcium in human neutrophils

1991 • 34 citations

Myocardial Release of Endothelin (ET) and Enhanced ETA Receptor-Mediated Coronary Vasoconstriction After Coronary Thrombosis and Thrombolysis in Pigs

1995 • 33 citations

Inactivation of endothelin by polymorphonuclear leukocyte-derived lytic enzymes

1991 • 31 citations

Augmented contractile response to endothelin and blunted endothelium-dependent relaxation in post-ischemic reperfused coronary arteries.

1992 • 31 citations

The effect of diltiazem on the coronary haemodynamic and cardiac functional effects produced by intracoronary administration of endothelin‐1 in the anaesthetized dog

1990 • 29 citations

Human Polymorphonuclear Leukocytes Generate and Degrade Endothelin-1 by Two Distinct Neutral Proteases

1991 • 24 citations

Endothelin-Receptor Antagonist FR 139317 Reduces Infarct Size in a Rabbit Model When Given Before, But Not After, Coronary Artery Occlusion

1997 • 14 citations