Early Afterdepolarizations and Arrhythmogenesis

Cardiac electrophysiology and arrhythmias

1985 • 937 citations

Characteristics and possible mechanism of ventricular arrhythmia dependent on the dispersion of action potential durations.

1983 • 747 citations

Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current.

1989 • 675 citations

Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore.

1986 • 549 citations

Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs

1984 • 544 citations

Circus movement in rabbit atrial muscle as a mechanism of tachycardia. II. The role of nonuniform recovery of excitability in the occurrence of unidirectional block, as studied with multiple microelectrodes.

1976 • 484 citations

Action potentials, afterpotentials, and arrhythmias.

1977 • 474 citations

The steady state TTX-sensitive (?window?) sodium current in cardiac Purkinje fibres

1979 • 468 citations

Monophasic action potential mapping in human subjects with normal electrocardiograms: direct evidence for the genesis of the T wave.

1987 • 352 citations

Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length.

1985 • 341 citations

Bradycardia-dependent triggered activity: relevance to drug-induced multiform ventricular tachycardia.

1983 • 321 citations

Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle.

1986 • 316 citations

Contraction-excitation feedback in myocardium. Physiological basis and clinical relevance.

1982 • 304 citations

Nervous Control of Cardiovascular Function

1985 • 263 citations

Effects of pacing on triggered activity induced by early afterdepolarizations.

1984 • 255 citations

Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibers.

1985 • 252 citations

QTU prolongation and polymorphic ventricular tachyarrhythmias due to bradycardia-dependent early afterdepolarizations. Afterdepolarizations and ventricular arrhythmias.

1988 • 248 citations

Electrophysiological and Beta-Receptor Blocking Effects of MJ 1999 on Dog and Rabbit Cardiac Tissue

1970 • 245 citations

A model for early afterdepolarizations: induction with the Ca2+ channel agonist Bay K 8644.

1988 • 244 citations

Slow currents through single sodium channels of the adult rat heart.

1985 • 242 citations

Cardiac Purkinje fibers: Cesium as a tool to block inward rectifying potassium currents

1976 • 241 citations

Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels.

1985 • 239 citations

Chloride ions and the membrane potential of Purkinje fibres

1961 • 231 citations

Magnesium therapy for torsades de pointes

1984 • 220 citations

Magnesium suppression of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium in dogs.

1988 • 214 citations

Mechanisms of action of lidocaine and quinidine on action potential duration in rabbit cardiac Purkinje fibers. An effect on steady state sodium currents?

1982 • 214 citations

Cesium chloride-induced long QT syndrome: demonstration of afterdepolarizations and triggered activity in vivo.

1985 • 206 citations

Der Aktionsstrom der Myokardfaser im Sauerstoffmangel

1954 • 202 citations

Quinidine-induced action potential prolongation, early afterdepolarizations, and triggered activity in canine Purkinje fibers. Effects of stimulation rate, potassium, and magnesium.

1989 • 198 citations

Fluctuations in membrane current driven by intracellular calcium in cardiac Purkinje fibers

1982 • 196 citations

Reentrant ventricular arrhythmias in the late myocardial infarction period in the dog. 13. Correlation of activation and refractory maps.

1985 • 192 citations

Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes.

1989 • 192 citations

Stretch activated ion channels in ventricular myocytes

1988 • 184 citations

Characteristics of reflection as a mechanism of reentrant arrhythmias and its relationship to parasystole.

1980 • 179 citations

Shortening of the action potential and reduction of pacemaker activity by lidocaine, quinidine, and procainamide in sheep cardiac purkinje fibers. An effect on Na or K currents?

1982 • 175 citations

Two levels of resting potential in cardiac Purkinje fibers.

1977 • 175 citations

Ventricular activation patterns of spontaneous and induced ventricular rhythms in canine one-day-old myocardial infarction. Evidence for focal and reentrant mechanisms.

1982 • 173 citations

The action current of the myocardial fibers in oxygen deficiency

1954 • 162 citations

Quinidine-induced inhibition of transient outward current in cardiac muscle

1987 • 160 citations

Differential response to right and left ansae subclaviae stimulation of early afterdepolarizations and ventricular tachycardia induced by cesium in dogs.

1988 • 145 citations

Recording of monophasic action potentials of the right ventricle in long QT syndromes complicated by severe ventricular arrhythmias

1983 • 137 citations

Pharmacological response of quinidine induced early afterdepolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms

1988 • 130 citations

Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers

1984 • 126 citations

Effects of quinidine on action potentials and ionic currents in isolated canine ventricular myocytes.

1988 • 126 citations

Cardiac Arrhythmias: The Role of Triggered Activity and Other Mechanisms.

1989 • 124 citations

Sodium current depression by lidocaine and quinidine in isolated ventricular cells

1981 • 124 citations

In vivo and in vitro antiarrhythmic and arrhythmogenic effects of N-acetyl procainamide.

1981 • 123 citations

Quinidine delays IK activation in guinea pig ventricular myocytes.

1988 • 109 citations

Single Na+ channels activated by veratridine and batrachotoxin.

1987 • 98 citations

Ventricular Tachyarrhythmias in the Long QT Syndromes

1984 • 93 citations

The effect of aconitine on the membrane current in cardiac muscle

1967 • 93 citations

Effects of low potassium or magnesium concentrations on isolated cardiac tissue

1987 • 92 citations

The effects of the Anemonia sulcata toxin (ATX II) on membrane currents of isolated mammalian myocytes.

1984 • 90 citations

Calcium current in isolated neonatal rat ventricular myocytes.

1987 • 78 citations

Drug-induced torsades de pointes: Role of early afterdepolarizations and dispersion of repolarization

1990 • 77 citations

Effects of quinidine on plateau currents of guinea-pig ventricular myocytes

1986 • 77 citations

Autonomic modulation of ventricular arrhythmia in cesium chloride-induced long QT syndrome.

1988 • 69 citations

Mechanisms of closure of cardiac sodium channels in rabbit ventricular myocytes: single-channel analysis.

1987 • 66 citations

A mechanism of torsades de pointes in a canine model.

1983 • 62 citations

Versuche mit Aconitin zum Problem der spontanen Erregungsbildung im Herzen

1960 • 60 citations

Acidosis-induced abnormal repolarization and repetitive activity in isolated dog Purkinje fibers.

1980 • 59 citations

A CELLULAR BASIS FOR THE PRIMARY LONG Q-T SYNDROMES

1988 • 58 citations

A mechanistic interpretation of the action of toxin II from Anemonia sulcata on the cardiac sodium channel

1987 • 39 citations

Abnormal Automaticity in Canine Purkinje Fibers Focally Subjected to Low External Concentrations of Calcium

1972 • 35 citations

Barium-induced spontaneous activity in sheep cardiac Purkinje fibers

1983 • 30 citations

Sodium channels in cardiac Purkinje cells

1987 • 29 citations

Electrophysiologic effects of amiloride in canine Purkinje fibers: evidence for a delayed effect on repolarization.

1985 • 27 citations

The differential response of normal and ischaemic Purkinje fibres to clofilium, d-sotalol and bretylium

1989 • 27 citations

Recent advances in understanding the mechanisms of drug-induced torsades de pointes arrhythmias

1989 • 27 citations

Epicardial activation patterns of torsade de pointes in canine hearts with quinidine-induced long QT interval but without myocardial infarction

1986 • 26 citations

Aktionspotential und Mechanogramm von Purkinje-F�den in tiefer Temperatur

1961 • 26 citations

Occurrence and transmission of localized repolarization abnormalities in vitro

1985 • 24 citations

Effects of clofilium on ischemic subendocardial Purkinje fibers 1 day postinfarction

1988 • 21 citations

[Experiments with aconitine on the problem of spontaneous stimulus formation in the heart].

1960 • 16 citations

In vitro characteristics of repolarization abnormality—A possible cause of arrhythmias

1986 • 13 citations

Veratrine, protoveratrine, and andromedotoxin arrhythmias in the isolated dog heart.

1957 • 7 citations

[Action potential and mechanogram of Purkinje's fibers at low temperatures].

1961 • 6 citations