The DNA polymerase α-primase complex couples DNA replication, cell-cycle progression and DNA-damage response

When Checkpoints Fail

1997 • 622 citations

Two steps in the assembly of complexes at yeast replication origins in vivo

1994 • 566 citations

Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

1994 • 559 citations

Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen.

1992 • 376 citations

DNA replication in eukaryotic cells

1997 • 346 citations

Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways.

1996 • 307 citations

The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication.

1994 • 299 citations

Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells.

1996 • 240 citations

Cell cycle-dependent phosphorylation of human DNA polymerase alpha.

1991 • 144 citations

The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication.

1993 • 125 citations

Replication factor A is required in vivo for DNA replication, repair, and recombination.

1994 • 125 citations

Cell Cycle-Dependent Phosphorylation and Dephosphorylation of the Yeast DNA Polymerase α-Primase B Subunit

1995 • 121 citations

A role for DNA primase in coupling DNA replication to DNA damage response

1997 • 119 citations

Cell cycle control of DNA synthesis in budding yeast

1992 • 118 citations

Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication.

1993 • 114 citations

Yeast DNA polymerases and their role at the replication fork

1995 • 110 citations

The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast

1996 • 100 citations

Mechanism of calf thymus DNA primase: Slow initiation, rapid polymerization, and intelligent termination

1993 • 99 citations

DNA replication in vitro by recombinant DNA‐polymerase‐α‐primase

1994 • 80 citations

Yeast pip3/mec3 Mutants Fail To Delay Entry into S Phase and To Slow DNA Replication in Response to DNA Damage, and They Define a Functional Link between Mec3 and DNA Primase

1996 • 79 citations

The isolated 48,000-dalton subunit of yeast DNA primase is sufficient for RNA primer synthesis.

1993 • 75 citations

A meiosis-specific protein kinase, Ime2, is required for the correct timing of DNA replication and for spore formation in yeast meiosis

1996 • 70 citations

Phosphorylation of DNA polymerase α-primase by Cyclin A-dependent kinases regulates initiation of DNA replication in vitro

1997 • 68 citations

Conditional mutations in the yeast DNA primase genes affect different aspects of DNA metabolism and interactions in the DNA polymerase alpha-primase complex.

1993 • 44 citations

Identification of the nuclear localization signal of mouse DNA primase: nuclear transport of p46 subunit is facilitated by interaction with p54 subunit

1996 • 41 citations

The Hepatitis B Virus Transactivator Protein, HBx, Interacts with Single-stranded DNA (ssDNA)

1996 • 38 citations

Phosphorylation of the DNA Polymerase -Primase B Subunit Is Dependent on Its Association with the p180 Polypeptide

1996 • 37 citations

Mechanism of initiation of in vitro DNA synthesis by the immunopurified complex between yeast DNA polymerase I and DNA primase

1986 • 19 citations