Participation of Mammalian Target of Rapamycin Complex 1 in Toll-Like Receptor 2– and 4–Induced Neutrophil Activation and Acute Lung Injury

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery

2003 • 4,197 citations

Upstream and downstream of mTOR

2004 • 4,085 citations

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2004 • 2,039 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1

2002 • 934 citations

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

2000 • 922 citations

Neutrophils and acute lung injury

2003 • 843 citations

The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways

1997 • 654 citations

Sirolimus-Eluting versus Uncoated Stents in Acute Myocardial Infarction

2006 • 571 citations

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

2007 • 508 citations

Epidemiology and Outcomes of Acute Lung Injury

2007 • 475 citations

Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury

2000 • 401 citations

The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

2002 • 394 citations

Regulatory functions of ubiquitination in the immune system

2002 • 392 citations

Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits

1985 • 369 citations

Stress-activated Protein Kinase-2/p38 and a Rapamycin-sensitive Pathway Are Required for C2C12 Myogenesis

1999 • 324 citations

mTOR, translational control and human disease

2005 • 321 citations

Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury

2008 • 295 citations

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

2008 • 265 citations

Risk Factors for ARDS in Patients Receiving Mechanical Ventilation for > 48 h

2008 • 173 citations

RelA Ser²⁷⁶ Phosphorylation Is Required for Activation of a Subset of NF-κB-Dependent Genes by Recruiting Cyclin-Dependent Kinase 9/Cyclin T1 Complexes

2008 • 166 citations

In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB

1995 • 164 citations

Mitochondrial Respiratory Complex I Regulates Neutrophil Activation and Severity of Lung Injury

2008 • 162 citations

PTEN Down-Regulation by Unsaturated Fatty Acids Triggers Hepatic Steatosis via an NF-κBp65/mTOR-Dependent Mechanism

2007 • 134 citations

Repression of gene expression by unphosphorylated NF-κB p65 through epigenetic mechanisms

2008 • 130 citations

Early Alterations in Neutrophil Activation Are Associated with Outcome in Acute Lung Injury

2003 • 129 citations

Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury

2007 • 125 citations

Mild hypothermia during hemorrhagic shock in rats improves survival without significant effects on inflammatory responses

2003 • 120 citations

Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-β

2000 • 112 citations

Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production

2008 • 83 citations

Hemorrhage activates NF-kappa B in murine lung mononuclear cells in vivo

1996 • 69 citations

Involvement of Vitronectin in Lipopolysaccaride-Induced Acute Lung Injury

2007 • 68 citations

Inhibition of Mammalian Target of Rapamycin Potentiates Thrombin-Induced Intercellular Adhesion Molecule-1 Expression by Accelerating and Stabilizing NF-κB Activation in Endothelial Cells

2005 • 65 citations

Kinetics and Dynamics of Single Oral Doses of Sirolimus in Sixteen Renal Transplant Recipients

1997 • 65 citations

Exposure to hydrogen peroxide diminishes NF-κB activation, IκB-α degradation, and proteasome activity in neutrophils

2007 • 64 citations

Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs

2004 • 62 citations

Interleukin‐1 receptor‐associated kinase (IRAK) ‐1‐ mediated NF‐κ activation requires cytosolic and nuclear activity

2008 • 61 citations

Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation

2008 • 52 citations

Topical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model

2008 • 49 citations

Variant IL-1 Receptor-Associated Kinase-1 Mediates Increased NF-κB Activity

2007 • 45 citations

Involvement of c-Jun NH2 Terminal Kinase and p38MAPK in Rapamycin-Mediated Inhibition of Neointimal Formation in Rat Carotid Arteries

2005 • 13 citations