Evidence of free radical damage in the central nervous system of guinea-pigs at the prolonged acute and early relapse stages of chronic relapsing experimental allergic encephalomyelitis

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Free radicals in biology and medicine

1991 • 17,840 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Formation of a thiobarbituric‐acid‐reactive substance from deoxyribose in the presence of iron salts

1981 • 830 citations

Oxygen radical mechanisms of brain injury following ischemia and reperfusion

1991 • 657 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes

1982 • 614 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

The molecular basis of brain injury and brain edema

1990 • 355 citations

Thiobarbituric acid‐reactivity following iron‐dependent free‐radical damage to amino acids and carbohydrates

1981 • 284 citations

Chronic relapsing experimental allergic encephalomyelitis: An experimental model of multiple sclerosis

1977 • 282 citations

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of inflammatory demyelination

1978 • 276 citations

Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown

1981 • 259 citations

Regional lipid peroxidation in rat brain in vitro: Possible role of endogenous iron

1985 • 244 citations

Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis

1988 • 199 citations

Free-radical damage to lipids, amino acids, carbohydrates and nucleic acids determined by thiobarbituric acid reactivity

1982 • 197 citations

Regional Distributions of Thiobarbituric Acid‐Reactive Products, Activities of Enzymes Regulating the Metabolism of Oxygen Free Radicals, and Some of the Related Enzymes in Adult and Aged Rat Brains

1986 • 163 citations

Effect of Reactive Oxygen Species on Myelin Membrane Proteins

1985 • 153 citations

Measurement of free and bound malondialdehyde in vitamin E‐deficient and‐supplemented rat liver tissues

1987 • 105 citations

The measurement of malondialdehyde in peroxidised ox-brain phospholipid liposomes

1977 • 100 citations

Attachment of myelin to coated pits on macrophages in experimental allergic encephalomyelitis

1983 • 88 citations

Mechanism of demyelination in allergic encephalomyelitis of guinea pigs. An electron microscopic study

1967 • 76 citations

LY178002 reduces rat brain damage after transient global forebrain ischemia.

1991 • 76 citations

Opsonization with Antimyelin Antibody Increases the Uptake and Intracellular Metabolism of Myelin in Inflammatory Macrophages

1986 • 74 citations

Antibody-induced generation of reactive oxygen radicals by brain macrophages in canine distemper encephalitis: a mechanism for bystander demyelination

1989 • 69 citations

Disorder in human myelin induced by superoxide radical: An investigation

1983 • 51 citations

Iron‐dependent peroxidation of rat brain: A regional study

1990 • 50 citations

Complement potentiates the degradation of myelin proteins by plasmin: Implications for a mechanism of inflammatory demyelination

1986 • 49 citations

The effect of Freund's adjuvants on blood-cerebrospinal fluid barrier permeability

1984 • 47 citations

Humoral immunity in chronic relapsing experimental autoimmune encephalomyelitis

1982 • 40 citations

Optimum conditions for inducing chronic relapsing experimental allergic encephalomyelitis in guinea pigs

1980 • 35 citations

Protective effect of the iron chelator deferoxamine on cold-induced brain edema

1989 • 35 citations

Antiviral antibodies stimulate production of reactive oxygen species in cultured canine brain cells infected with canine distemper virus

1989 • 32 citations

[64] Assay of lipofuscin/ceroid pigment in vivo during aging

1984 • 28 citations

Pathogenesis of vasogenic edema in focal cerebral ischemia. Role of superoxide radicals.

1990 • 28 citations

Inhibition of allergic encephalomyelitis by the iron chelating agent desferrioxamine: differential effect depending on type of sensitizing encephalitogen

1988 • 23 citations

Measurement of free radical scavengers in the spinal cord of rats with experimental autoimmune encephalomyelitis

1989 • 19 citations

Increased concentrations of uric acid in the spinal cord of rats with chronic relapsing experimental allergic encephalomyelitis

1986 • 15 citations

CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: CEREBROSPINAL FLUID CYTOLOGY AND A COMPARISON WITH MENINGEAL AND SPINAL CORD PATHOLOGY

1983 • 12 citations

[Lipid peroxidation in experimental allergic encephalomyelitis].

1984 • 4 citations