Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Primer3 on the WWW for General Users and for Biologist Programmers

2003 • 15,242 citations

Frontotemporal lobar degeneration

1998 • 4,937 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

2006 • 1,929 citations

Clinical and Pathological Diagnosis of Frontotemporal Dementia

2001 • 1,445 citations

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

2004 • 1,334 citations

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

2001 • 1,012 citations

Frontotemporal dementia: Clinicopathological correlations

2006 • 468 citations

Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis

2003 • 467 citations

Cellular Localization of Gene Expression for Progranulin

2000 • 329 citations

novoSNP, a novel computational tool for sequence variation discovery

2005 • 278 citations

A novel presenilin 1 mutation associated with Pick's disease but not β‐amyloid plaques

2004 • 210 citations

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays

2001 • 204 citations

Mutant valosin‐containing protein causes a novel type of frontotemporal dementia

2005 • 175 citations

mRNA export: an assembly line from genes to nuclear pores

2004 • 168 citations

Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease

2003 • 163 citations

Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21-22

2001 • 160 citations

Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption.

2000 • 124 citations

Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects

2003 • 121 citations

PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells

2004 • 119 citations

Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval

2002 • 107 citations

A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17

2006 • 103 citations

A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD

2006 • 91 citations

Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region

2005 • 87 citations

Granulin Precursor Gene: A Sex Steroid-Inducible Gene Involved in Sexual Differentiation of the Rat Brain

2002 • 73 citations

Progranulin Mutations in Ubiquitin-Positive Frontotemporal Dementia Linked to Chromosome 17q21

2006 • 64 citations

Characterization of Ubiquitinated Intraneuronal Inclusions in a Novel Belgian Frontotemporal Lobar Degeneration Family

2006 • 45 citations