20-O-Acylcamptothecin Derivatives: Evidence for Lactone Stabilization

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

1991 • 513 citations

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

1992 • 456 citations

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

1989 • 406 citations

The structural basis of camptothecin interactions with human serum albumin: impact on drug stability

1994 • 316 citations

Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogs

1980 • 232 citations

Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin.

1991 • 231 citations

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

1991 • 209 citations

Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin.

1991 • 179 citations

Preferential Binding of the Carboxylate Form of Camptothecin by Human Serum Albumin

1993 • 168 citations

Camptothecin-20-PEG ester transport forms: the effect of spacer groups on antitumor activity

1998 • 104 citations

Kinetics of lactone hydrolysis in antitumor drugs of camptothecin series as studied by fluorescence spectroscopy

1998 • 98 citations

Antineoplastic Agents from Plants

1977 • 93 citations

Drug Delivery Systems. 2. Camptothecin 20-O-Poly(ethylene glycol) Ester Transport Forms

1996 • 92 citations

Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogs of camptothecin

1990 • 72 citations

Protection of tertiary hydroxyl groups as methylthiomethyl ethers

1976 • 48 citations

Structural modifications of camptothecin and effects on topoisomerase I inhibition

1992 • 46 citations

Prodrug analogs of the antitumor alkaloid camptothecin

1979 • 42 citations

PEG Thiazolidine-2-thione, a Novel Reagent for Facile Protein Modification: Conjugation of Bovine Hemoglobin

1996 • 40 citations

The water-insoluble camptothecin analogues: Promising drugs for the effective treatment of haematological malignancies

1995 • 28 citations

Experiments on the synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues

1976 • 25 citations

Stereoselective acylation of 20-(S)-camptothecin with amino acid derivatives using scandium triflate/DMAP

1998 • 20 citations