Camptothecin-20-PEG ester transport forms: the effect of spacer groups on antitumor activity

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

Chemistry of the amino acids

1961 • 1,404 citations

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

1991 • 513 citations

A novel connector linkage applicable in prodrug design

1981 • 328 citations

Polymeric Antitumor Agents on a Molecular and on a Cellular Level?

1981 • 315 citations

Synthesis and evaluation of some water-soluble prodrugs and derivatives of taxol with antitumor activity

1992 • 247 citations

Drug Delivery Systems: Water Soluble Taxol 2‘-Poly(ethylene glycol) Ester ProdrugsDesign and in Vivo Effectiveness

1996 • 221 citations

Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity

1989 • 219 citations

A CONVENIENT METHOD FOR THE SYNTHESIS OF CARBOXYLIC ESTERS

1975 • 201 citations

Controlled biodegradability of polymers — a key to drug delivery systems

1984 • 155 citations

Phase I clinical and pharmacokinetic trial of dextran conjugated doxorubicin (AD-70, DOX-OXD)

1993 • 146 citations

Site‐specific drug delivery

1987 • 143 citations

Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I

1995 • 143 citations

Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine)

1983 • 126 citations

Design, synthesis and biological activity of protaxols

1993 • 123 citations

Targetable polymeric prodrugs

1987 • 109 citations

Co-operative Effects of Functional Groups in Peptides. I. Aspartyl-serine Derivatives

1962 • 104 citations

Cyclization-activated prodrugs. Basic carbamates of 4-hydroxyanisole

1990 • 100 citations

Drug Delivery Systems. 2. Camptothecin 20-O-Poly(ethylene glycol) Ester Transport Forms

1996 • 92 citations

The tumor blood vessel as an ideal target for macromolecular anticancer agents

1992 • 79 citations

Prodrugs as drug delivery systems XXVI. Preparation and enzymatic hydrolysis of various water-soluble amino acid esters of metronidazole

1984 • 54 citations

A novel solution-stable, water-soluble prodrug type for drugs containing a hydroxyl or an NH-acidic group

1989 • 42 citations

Potential and limitations of drug targeting: An overview

1985 • 40 citations

Synthesis, in vitro kinetics and in vivo studies on protein conjugates of AZT: Evaluation as a transport system to increase brain delivery

1993 • 38 citations

Biodegradable soluble macromolecules as drug carriers

1989 • 37 citations

Comparison of efficacy, toxicity and pharmacokinetics of free adriamycin and adriamycin linked to oxidized dextran in rats.

1989 • 36 citations

N-(Acyloxyalkoxycarbonyl) derivatives as potential prodrugs of amines. I. kinetics and mechanism of degradation in aqueous solutions

1987 • 31 citations

929 Clinical phase I trial of PK1 (HPMA co-polymer doxorubicin)

1995 • 29 citations

Intramolecular nucleophilic aminolysis of aliphatic esters. Cyclization of methyl 2-aminomethylbenzoate to phthalimidine

1976 • 24 citations

Antitumor Agents LXII: Synthesis and Biological Evaluation of Podophyllotoxin Esters and Related Derivatives

1983 • 24 citations