Structure of the Mammalian NOS Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inhibitors

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The PyMOL Molecular Graphics System

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The CCP4 suite: programs for protein crystallography

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Improved methods for building protein models in electron density maps and the location of errors in these models

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The Cambridge Structural Database: a quarter of a million crystal structures and rising

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AMoRe: an automated package for molecular replacement

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PRODRG: a tool for high-throughput crystallography of protein–ligand complexes

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Comparative Protein Structure Modeling of Genes and Genomes

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CATH – a hierarchic classification of protein domain structures

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NITRIC OXIDE: A Physiologic Messenger Molecule

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Determination of sulfhydryl groups with 2,2′- or 4,4′-dithiodipyridine

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Methods in nitric oxide research

1996 • 826 citations

Methods in Nitric Oxide Research

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Homocysteine Impairs the Nitric Oxide Synthase Pathway

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Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway

2004 • 551 citations

Remarks about protein structure precision

1999 • 464 citations

Biological significance of endogenous methylarginines that inhibit nitric oxide synthases

1999 • 456 citations

Analysis of zinc binding sites in protein crystal structures

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Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase

1996 • 409 citations

Asymmetrical Dimethylarginine

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Structural basis for Ca2+-induced activation of human PAD4

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The dual personality of NO

2000 • 350 citations

Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis

2003 • 339 citations

Blocking NO synthesis: how, where and why?

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Endothelial Dysfunction Induced by Hyperhomocyst(e)inemia

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Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide

2003 • 300 citations

The DDAH/ADMA/NOS pathway

2003 • 300 citations

Plasma Concentration of Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, Is Elevated in Monkeys With Hyperhomocyst(e)inemia or Hypercholesterolemia

2000 • 290 citations

Protein Methylation

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Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase.

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Chromosomal Localization, Gene Structure, and Expression Pattern of DDAH1: Comparison with DDAH2 and Implications for Evolutionary Origins

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Circulating no pool: assessment of nitrite and nitroso species in blood and tissues

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Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer’s disease

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Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis

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A novel superfamily of enzymes that catalyze the modification of guanidino groups

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Preparation of l-homocysteine from l-homocysteine thiolactone

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Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA

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Crystal Structures of Arginine Deiminase with Covalent Reaction Intermediates

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GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo

2005 • 85 citations

Distribution of Free Methylarginines in Rat Tissues and in the Bovine Brain

1992 • 69 citations

Zn(II)-free Dimethylargininase-1 (DDAH-1) Is Inhibited upon Specific Cys-S-Nitrosylation

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Selective Substrate-Based Inhibitors of Mammalian Dimethylarginine Dimethylaminohydrolase

2005 • 55 citations

Structural and Functional Characterization of the Zn(II) Site in Dimethylargininase-1 (DDAH-1) from Bovine Brain

2001 • 52 citations

Glycolysis and Proteases as Targets for the Design of New Anti- Trypanosome Drugs

2002 • 43 citations

Characterization of a Transient Covalent Adduct Formed during Dimethylarginine Dimethylaminohydrolase Catalysis

2005 • 41 citations

Characterization of Dimethylargininase from Bovine Brain: Evidence for a Zinc Binding Site

1998 • 41 citations

Searching for DDAH Inhibitors: S-Nitroso-<scp>l</scp>-homocysteine Is a Chemical Lead

2005 • 33 citations

Endothelial alterations in hypercholesterolemia: more than simply vasodilator dysfunction.

1998 • 32 citations

Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates

2005 • 23 citations