Synonymous Nucleotide Divergence and Saturation: Effects of Site-Specific Variations in Codon Bias and Mutation Rates

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

1986 • 4,940 citations

Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology

1987 • 4,385 citations

Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: Approximate methods

1994 • 2,921 citations

Fundamentals of molecular evolution

1991 • 1,721 citations

Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes

1981 • 858 citations

Maximum-likelihood models for combined analyses of multiple sequence data

1996 • 414 citations

Substitution rate variation among sites in hypervariable region 1 of human mitochondrial DNA

1993 • 307 citations

Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli.

1993 • 300 citations

Fitting Discrete Probability Distributions to Evolutionary Events

1971 • 277 citations

Model of effectively neutral mutations in which selective constraint is incorporated

1979 • 221 citations

Mammalian gene evolution: Nucleotide sequence divergence between mouse and rat

1993 • 215 citations

MUTATIONAL SPECIFICITY IN BACTERIA

1983 • 208 citations

Spontaneous mutation in the Escherichia coli lacI gene.

1991 • 200 citations

Mitochondrial mutational spectra in human cells and tissues

1997 • 181 citations

Reduced synonymous substitution rate at the start of enterobacterial genes

1993 • 172 citations

Estimates of DNA and protein sequence divergence: an examination of some assumptions.

1984 • 122 citations

Evaluation of several methods for estimating phylogenetic trees when substitution rates differ over nucleotide sites

1995 • 94 citations

Very short patch repair: reducing the cost of cytosine methylation

1996 • 93 citations

DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli

1994 • 84 citations

Synonymous substitution rates in enterobacteria.

1995 • 78 citations

Codon bias in Escherichia coli: the influence of codon context on mutation and selection

1997 • 77 citations

Synonymous Nucleotide Divergence: What Is “Saturation”?

1996 • 52 citations

Variation in synonymous substitution rates among mammalian genes and the correlation between synonymous and nonsynonymous divergences

1995 • 48 citations

Synonymous substitution-rate constants in Escherichia coli and Salmonella typhimurium and their relationship to gene expression and selection pressure

1995 • 44 citations

Spectrum of mutations that occur under selective and non-selective conditions in E. coli

1991 • 44 citations

The close proximity ofEscherichia coli genes: Consequences for stop codon and synonymous codon use

1996 • 43 citations

The lacI Gene as a Target for Mutation in Transgenic Rodents and Escherichia coli

1998 • 43 citations

Molecular considerations in the evolution of bacterial genes

1991 • 40 citations

Evolutionary distances between nucleotide sequences based on the distribution of substitution rates among sites as estimated by parsimony

1997 • 38 citations

Site-Specific Codon Bias in Bacteria

1996 • 33 citations

The Effects of Variable Mutation Rates Across Sites on the Phylogenetic Estimation of Effective Population Size or Mutation Rate of DNA Sequences

1996 • 15 citations

Genetic Analysis of Elongation Factor Tu and the Tuf Genes

1995 • 1 citations