Chromatin structure and the expression of globin-encoding genes

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Supercoiling of the DNA template during transcription.

1987 • 1,909 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

1991 • 1,321 citations

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

1989 • 931 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

1993 • 655 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

The erythroid-specific transcription factor eryf1: A new finger protein

1989 • 608 citations

An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.

1988 • 518 citations

Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages

1990 • 481 citations

The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence

1979 • 445 citations

A 200 base pair region at the 5$prime; end of the chicken adult $beta;-globin gene is accessible to nuclease digestion

1981 • 443 citations

Role of Nucleosomal Cores and Histone H1 in Regulation of Transcription by RNA Polymerase II

1991 • 379 citations

The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein.

1988 • 362 citations

Transcription-driven supercoiling of DNA: Direct biochemical evidence from in vitro studies

1989 • 357 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

Developmental regulation of β-globin gene switching

1988 • 328 citations

Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis

1993 • 301 citations

β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

1983 • 266 citations

Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult β-globin gene: Nature of the binding domain

1985 • 255 citations

Specific factor conferring nuclease hypersensitivity at the 5' end of the chicken adult beta-globin gene.

1984 • 249 citations

The transcriptionally-active MMTV promoter is depleted of histone H1

1992 • 222 citations

The erythroid cells and haemoglobins of the chick embryo

1973 • 206 citations

Nucleosome Core Displacement in Vitro via a Metastable Transcription Factor-Nucleosome Complex

1992 • 198 citations

A 3′ enhancer is required for temporal and tissue-specific transcriptional activation of the chicken adult β-globin gene

1986 • 192 citations

Activation of globin genes during chicken development

1981 • 164 citations

Structure and evolution of a human erythroid transcription factor

1990 • 160 citations

A nucleosome core is transferred out of the path of a transcribing polymerase

1992 • 155 citations

The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome.

1990 • 155 citations

Regulated gene expression in transfected primary chicken erythrocytes.

1986 • 144 citations

Formation of nucleosomes on positively supercoiled DNA.

1991 • 133 citations

Structure and promoter activity of the gene for the erythroid transcription factor GATA-1.

1991 • 129 citations

Mutational analysis of the chicken beta-globin enhancer reveals two positive-acting domains.

1988 • 120 citations

Developmental Regulation of Topoisomerase II Sites and DNase I-Hypersensitive Sites in the Chicken β-Globin Locus

1990 • 108 citations

Site-independent expression of the chicken βA-globin gene in transgenic mice

1990 • 106 citations

An Enhancer/Locus Control Region Is Not Sufficient To Open Chromatin

1993 • 90 citations

Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus.

1990 • 66 citations

Identification and characterization of a chicken alpha-globin enhancer.

1989 • 58 citations

The developmental switch in embryonic ρ-globin expression is correlated with erythroid lineage-specific differences in transcription factor levels

1992 • 55 citations

An enhancer/locus control region is not sufficient to open chromatin.

1993 • 46 citations

Mechanism of developmental regulation of alpha pi, the chicken embryonic alpha-globin gene.

1993 • 28 citations