Compensatory mechanisms in experimental and human Parkinsonism: towards a dynamic approach

The functional anatomy of basal ganglia disorders

1989 • 5,166 citations

Functional architecture of basal ganglia circuits: neural substrates of parallel processing

1990 • 4,029 citations

Primate models of movement disorders of basal ganglia origin

1990 • 3,722 citations

D ₁ and D ₂ Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons

1990 • 2,873 citations

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Reversal of Experimental Parkinsonism by Lesions of the Subthalamic Nucleus

1990 • 1,875 citations

Verteilung Von Noradrenalin Und Dopamin (3-Hydroxytyramin) Im Gehirn Des Menschen Und Ihr Verhalten Bei Erkrankungen Des Extrapyramidalen Systems

1960 • 1,863 citations

An Essay on the Shaking Palsy

2002 • 1,658 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Dopamine (3-hydroxytyramine) and brain function.

1966 • 1,401 citations

The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism

1994 • 1,352 citations

Functional anatomy of the basal ganglia. II. The place of subthalamic nucleus and external pallidium in basal ganglia circuitry

1995 • 1,339 citations

The control of firing pattern in nigral dopamine neurons: burst firing

1984 • 1,326 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

1988 • 1,235 citations

Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease

1992 • 1,088 citations

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

1995 • 1,084 citations

Functional recovery in parkinsonian monkeys treated with GDNF

1996 • 955 citations

Are New Neurons Formed in the Brains of Adult Mammals?

1962 • 930 citations

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1984 • 913 citations

Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines

1984 • 866 citations

The control of firing pattern in nigral dopamine neurons: single spike firing

1984 • 856 citations

The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systems

1984 • 815 citations

Functional and pathophysiological models of the basal ganglia

1996 • 736 citations

Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro

1989 • 734 citations

Dendritic release of dopamine in the substantia nigra

1981 • 732 citations

Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral Supersensitivity

1977 • 716 citations

Electrophysiology of mammalian thalamic neurones in vitro

1982 • 715 citations

ELECTROPHYSIOLOGY OF HIPPOCAMPAL NEURONS: II. AFTER-POTENTIALS AND REPETITIVE FIRING

1961 • 683 citations

Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry

1988 • 663 citations

Self-inhibition by Dopaminergic Neurons

1975 • 645 citations

Release of dopamine from dendrites in rat substantia nigra

1976 • 644 citations

In Vivo Measurement of Dopamine and Its Metabolites by Intracerebral Dialysis: Changes After d‐Amphetamine

1983 • 615 citations

Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta.

1987 • 611 citations

Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies.

1993 • 610 citations

Reversal of Rigidity and Improvement in Motor Performance by Subthalamic High‐frequency Stimulation in MPTP‐treated Monkeys

1993 • 609 citations

Effect of GPi pallidotomy on motor function in Parkinson's disease

1995 • 600 citations

Compensations after lesions of central dopaminergic neurons: some clinical and basic implications

1990 • 597 citations

Efferent projections of the subthalamic nucleus in the rat: Light and electron microscopic analysis with the PHA‐L method

1987 • 580 citations

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis

1984 • 576 citations

Intercellular communication in the brain: Wiring versus volume transmission

1995 • 555 citations

Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: Light and electron microscopy

1995 • 540 citations

Lesion of the subthalamic nucleus for the alleviation of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced parkinsonism in the primate

1991 • 526 citations

Parkinson's disease: pathophysiology

1991 • 521 citations

Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats

1988 • 516 citations

Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization

1980 • 498 citations

Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man

1996 • 488 citations

ACUTE REGULATION OF TYROSINE HYDROXYLASE BY NERVE ACTIVITY AND BY NEUROTRANSMITTERS VIA PHOSPHORYLATION

1989 • 487 citations

Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents

1995 • 483 citations

Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain

1994 • 473 citations

The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons

1996 • 473 citations

Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1989 • 455 citations

Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets

1994 • 454 citations

Drug‐Induced Changes in the Release of ³H‐Monoamines from Field Stimulated Rat Brain Slices

1971 • 453 citations

Receptor basis for dopaminergic supersensitivity in Parkinson's disease

1978 • 447 citations

TREATMENT OF PARKINSONISM BY STEREOTACTIC THERMOLESIONS IN THE PALLIDAL REGION. A clinical evaluation of 81 cases.

1960 • 429 citations

Lesions of Central Norepinephrine Terminals with 6-OH-Dopamine: Biochemistry and Fine Structure

1969 • 421 citations

Altered Tonic Activity of Neurons in the Globus Pallidus and Subthalamic Nucleus in the Primate MPTP Model of Parkinsonism

1987 • 420 citations

Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study

1994 • 405 citations

Adrenal Medulla Grafts Enhance Recovery of Striatal Dopaminergic Fibers

1987 • 398 citations

The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method.

1991 • 393 citations

The neurochemistry of Parkinson's disease: effect of L-dopa therapy.

1975 • 386 citations

Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease

1990 • 376 citations

Regeneration of monoaminergic and cholinergic neurons in the mammalian central nervous system

1979 • 374 citations

Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice

1990 • 364 citations

Hyperactivity of Remaining Dopaminergic Neurones after Partial Destruction of the Nigro-striatal Dopaminergic System in the Rat

1973 • 363 citations

An [¹⁸F]dopa–PET and clinical study of the rate of progression in Parkinson’s disease

1996 • 359 citations

GABAA receptor-mediated inhibition of rat substantia nigra dopaminergic neurons by pars reticulata projection neurons

1995 • 356 citations

Tonic Activation of NMDA Receptors Causes Spontaneous Burst Discharge of Rat Midbrain Dopamine Neurons In Vivo

1993 • 350 citations

Comparison of therapeutic effects and mortality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson's disease

1995 • 345 citations

Monosynaptic inhibition of neurons of the substantia nigra by caudatonigral fibers

1971 • 344 citations

A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions

1983 • 342 citations

Neurochemical Compensation After Nigrostriatal Bundle Injury in an Animal Model of Preclinical Parkinsonism

1984 • 340 citations

Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus

1996 • 340 citations

Effects ofl-DOPA on extracellular dopamine in striatum of normal and 6-hydroxydopamine-treated rats

1990 • 334 citations

Pattern of brain destruction in Parkinson's and Alzheimer's diseases

1996 • 325 citations

Analysis of the clinical problems in parkinsonism and the complications of long‐term levodopa therapy

1979 • 319 citations

Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum

1985 • 317 citations

Glutamate and Parkinson’s disease

1996 • 315 citations

Hemiparkinsonism in monkeys after unilateral internal carotid artery artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1986 • 309 citations

The identification of striatal and pallidal neurons projecting to substantia nigra

1975 • 309 citations

Electrophysiology of dopamine-denervated striatal neurons

1993 • 308 citations

Nucleus tegmenti pedunculopontinus: Efferent connections with special reference to the basal ganglia, studied in the rat by anterograde and retrograde transport of horseradish peroxidase

1983 • 307 citations

Prolonged and Extrasynaptic Excitatory Action of Dopamine Mediated by D1 Receptors in the Rat StriatumIn Vivo

1997 • 303 citations

In vivo presynaptic control of dopamine release in the cat caudate nucleus—II. Facilitatory or inhibitory influence ofl-glutamate

1986 • 290 citations

Efferent projections of the subthalamic nucleus in the squirrel monkey as studied by the PHA‐L anterograde tracing method

1990 • 288 citations

Fluctuations of disability in Parkinson's disease – clinical aspects

1981 • 281 citations

Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity

1985 • 279 citations

Somatosensory inattention after dopamine-depleting intracerebral 6-OHDA injections: Spontaneous recovery and pharmacological control

1979 • 279 citations

[Effects of the stimulation of the subthalamic nucleus in Parkinson disease].

1993 • 276 citations

Glutamatergic inputs from the pedunculopontine nucleus to midbrain dopaminergic neurons in primates:Phaseolus vulgaris-leucoagglutinin anterograde labeling combined with postembedding glutamate and GABA immunohistochemistry

1996 • 267 citations

Striatal dopamine deficiency in parkinson's disease: Role of aging

1989 • 266 citations

High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey

1996 • 265 citations

Subthalamotomy in parkinsonian monkeys Behavioural and biochemical analysis

1996 • 258 citations

Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum

1992 • 258 citations

Dopaminergic Neurons Intrinsic to the Primate Striatum

1997 • 258 citations

GM1 ganglioside stimulates the regeneration of dopaminergic neurons in the central nervous system

1983 • 255 citations

The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat

1990 • 254 citations

Recovery of Feeding and Drinking by Rats after Intraventricular 6-Hydroxydopamine or Lateral Hypothalamic Lesions

1973 • 251 citations

Der L-Dioxyphenylalanin (=L-DOPA)-Effekt beim Parkinson-Syndrom des Menschen: Zur Pathogenese und Behandlung der Parkinson-Akinese

1962 • 248 citations

Effect of dopamine receptor agonists and antagonists on release of dopamine in the rabbit caudate nucleus in vitro

1978 • 242 citations

Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat.

1977 • 237 citations

Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding

1979 • 237 citations

RELEASE OF NEWLY SYNTHESIZED DOPAMINE FROM DOPAMINE-CONTAINING TERMINALS IN THE STRIATUM OF THE RAT

1969 • 236 citations

Chronic exposure to low doses of MPTP. I. Cognitive deficits in motor asymptomatic monkeys

1990 • 236 citations

Firing properties of substantia nigra dopaminergic neurons in freely moving rats

1985 • 235 citations

Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity

1992 • 231 citations

CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut.

1973 • 230 citations

The dopamine transporter: A crucial component regulating dopamine transmission

1997 • 230 citations

Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta

1995 • 230 citations

Enhancement of Dopamine-Stimulated Adenylate Cyclase Activity in Rat Caudate after Lesions in Substantia Nigra: Evidence for Denervation Supersensitivity

1974 • 228 citations

Nonlinear relationship between impulse flow, dopamine release and dopamine elimination in the rat brainin vivo

1994 • 227 citations

Electrophysiology of pars compacta cells in the in vitro substantia nigra—a possible mechanism for dendritic release

1984 • 226 citations

Pedunculopontine nucleus in the squirrel monkey: Cholinergic and glutamatergic projections to the substantia nigra

1994 • 225 citations

Effects of dopaminergic agonists and antagonists of feeding in intact and 6-hydroxydopamine-treated rats.

1977 • 222 citations

Iontophoretically administered drugs acting at the N‐methyl‐D‐aspartate receptor modulate burst firing in A9 dopamine neurons in the rat

1992 • 219 citations

Glutamate/dopamine D₁/D₂ balance in the basal ganglia and its relevance to Parkinson' disease

1995 • 216 citations

[3H]spiperone binding, dopamine and HVA concentrations in Parkinson's disease and supranuclear palsy

1984 • 215 citations

Dual character, asynaptic and synaptic, of the dopamine innervation in adult rat neostriatum: A quantitative autoradiographic and immunocytochemical analysis

1996 • 215 citations

High-frequency stimulation of the globus pallidus internalis in Parkinson's disease: a study of seven cases

1997 • 211 citations

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus

1984 • 209 citations

Adrenal medullary autografts into the basal ganglia of Cebus monkeys: Injury-induced regeneration

1988 • 205 citations

Release of dopamine evoked by electrical stimulation of the motor and visual areas of the cerebral cortex in both caudate nuclei and in the substantia nigra in the cat

1978 • 202 citations

6-hydroxydopamine treatments enhance behavioral responses to intracerebral microinjection of D1- and D2-dopamine agonists into nucleus accumbens and striatum without changing dopamine antagonist binding.

1987 • 201 citations

Animal Models of Parkinsonism Using Selective Neurotoxins: Clinical and Basic Implications

1989 • 194 citations

Parkinson's disease and dementia

1987 • 194 citations

Survival, Integration, and Differentiation of Neural Stem Cell Lines after Transplantation to the Adult Rat Striatum

1997 • 191 citations

Ultrastructural localization of D1 dopamine receptor immunoreactivity in rat striatonigral neurons and its relation with dopaminergic innervation

1996 • 191 citations

Changes in striatal dopamine neurotransmission assessed with microdialysis following recovery from a bilateral 6-OHDA lesion: variation as a function of lesion size

1990 • 191 citations

Electrical membrane properties of rat substantia nigra compacta neurons in an in vitro slice preparation

1986 • 187 citations

Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events

1996 • 187 citations

Recovery from experimental parkinsonism in primates with GM1 ganglioside treatment

1992 • 187 citations

Effect of Nondopaminergic Drugs on L-DOPA-Induced Dyskinesias in MPTP-Treated Monkeys

1993 • 179 citations

The glutamate-mediated release of dopamine in the rat striatum: Further characterization of the dual excitatory-inhibitory function

1990 • 179 citations

Activity of dopamine neurons in the behaving primate

1992 • 178 citations

Chemical anatomy of primate basal ganglia

1995 • 172 citations

Characteristics of Electrically Evoked Somatodendritic Dopamine Release in Substantia Nigra and Ventral Tegmental Area In Vitro

1997 • 172 citations

A cholinergic projection to the rat substantia nigra from the pedunculopontine tegmental nucleus

1987 • 168 citations

Neurochemical and behavioral effects of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) in rat, guinea pig, and monkey.

1984 • 167 citations

Statistical properties of neuronal spike trains in the substantia nigra: Cell types and their interactions

1977 • 163 citations

Subthalamic nucleus cell firing in the 6-OHDA-treated rat: basal activity and response to haloperidol

1992 • 163 citations

Characterisation of Inhibitory 5‐Hydroxytryptamine Receptors That Modulate Dopamine Release in the Striatum

1981 • 162 citations

Time Course of Adaptations in Dopamine Biosynthesis, Metabolism, and Release Following Nigrostriatal Lesions: Implications for Behavioral Recovery from Brain Injury

1987 • 160 citations

A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey

1997 • 159 citations

Gabaergic nerve terminals decrease in the substantia nigra following hemitransections of the striatonigral and pallidonigral pathways

1980 • 159 citations

Primate neostriatal neurons containing tyrosine hydroxylase: Immunohistochemical evidence

1987 • 159 citations

Excitotoxic lesions of the pedunculopontine tegmental nucleus produce contralateral hemiparkinsonism in the monkey

1997 • 156 citations

Neurotrophic factor gene expression in astrocytes during development and following injury

1994 • 155 citations

Compartmental origins of striatal efferent projections in the cat

1989 • 152 citations

A microiontophoretic study on the nature of the putative synaptic neurotransmitter involved in the pedunculopontine-substantia nigra pars compacta excitatory pathway of the rat

1986 • 151 citations

Detecting behaviorally relevant changes in extracellular dopamine with microdialysis

1987 • 150 citations

Electrophysiological properties of mouse dopamine neurons: In vivo and in vitro studies

1984 • 149 citations

Increased dopamine release from striata of rats after unilateral nigrostriatal bundle damage

1988 • 149 citations

Morphological changes in the rat neostriatum after unilateral 6-hydroxydopamine injections into the nigrostriatal pathway

1993 • 146 citations

Chronic low‐dose levodopa therapy in Parkinson's disease

1984 • 145 citations

The effect of fetal mesencephalon implants on primate MPTP-induced parkinsonism

1990 • 145 citations

Decreased tyrosine hydroxylase messenger RNA in the surviving dopamine neurons of the substantia nigra in parkinson's disease: An in situ hybridization study

1990 • 143 citations

Increased dopamine efflux from striatal slices during development and after nigrostriatal bundle damage

1987 • 143 citations

Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations.

1996 • 141 citations

Structure of the Human Tyrosine Hydroxylase Gene: Alternative Splicing from a Single Gene Accounts for Generation of Four mRNA Types1

1988 • 141 citations

5-hydroxydopamine-labeled dopaminergic axns: Three-dimensional reconstructions of axons, synapses and postsynaptic targets in rat neostriatum

1994 • 138 citations

Clinical observations on the rate of progression of idiopathic parkinsonism

1994 • 137 citations

Characterization of dopamine release in the substantia nigra by in vivo microdialysis in freely moving rats

1991 • 137 citations

Tyrosine hydroxylase-like immunoreactive neurons in the striatum of the rat

1989 • 136 citations

Dopamine efflux from striatal slices after intracerebral 6-hydroxydopamine: evidence for compensatory hyperactivity of residual terminals.

1990 • 136 citations

Serotonergic sprouting is induced by dopamine-lesion in substantia nigra of adult rat brain

1991 • 135 citations

Differential expression of tyrosine hydroxylase and membrane dopamine transporter genes in subpopulations of dopaminergic neurons of the rat mesencephalon

1994 • 135 citations

Parkinson's disease and the adaptive capacity of the nigrostriatal dopamine system: possible neurochemical mechanisms.

1993 • 135 citations

Do Compensatory Processes Underlie the Preclinical Phase of Neurodegenerative Disease? Insights from an Animal Model of Parkinsonism

1997 • 134 citations

III. Primate model of parkinsonism: Selective lesion of nigrostriatal neurons by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine produces an extrapyramidal syndrome in rhesus monkeys

1985 • 134 citations

The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat

1984 • 133 citations

Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease?

1990 • 133 citations

Output architecture of the primate putamen

1993 • 132 citations

Effects of intraventricular 6-hydroxydopamine on the dopaminergic innervation of striatum: Histochemical and neurochemical analysis

1986 • 131 citations

The lennox‐gastaut syndrome: Metabolic subtypes determined by 2‐deoxy‐2 [¹⁸F]fluoro‐d‐glucose positron emission tomography

1987 • 129 citations

Alleviation of experimental hemiparkinsonism by high‐frequency stimulation of the subthalamic nucleus in primates: A comparison with <scp>L</scp>‐dopa treatment

1996 • 128 citations

Long-term evaluation of hemiparkinsonian monkeys after adrenal autografting or cavitation alone

1990 • 127 citations

Chapter 70 Transient behavioral recovery in hemiparkinsonian primates after adrenal medullary allografts

1988 • 124 citations

Extracellular dopamine in striatum: Influence of nerve impulse activity in medial forebrain bundle and local glutamatergic input

1992 • 123 citations

Compensatory changes in striatal dopamine neurons following recovery from injury induced by 6-OHDA or methamphetamine: A review of evidence from microdialysis studies.

1990 • 121 citations

Decreased striatal D1 binding density following mesotelencephalic 6-hydroxydopamine injections: an autoradiographic analysis

1989 • 119 citations

Pedunculopontine-evoked excitation of substantia nigra neurons in the rat

1984 • 119 citations

Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors

1994 • 118 citations

Wiring and volume transmission in the central nervous system: the concept of closed and open synapses

1996 • 116 citations

Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys

1995 • 116 citations

Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in parkinson's disease

1994 • 116 citations

Presynaptic D2 dopaminergic receptors mediate inhibition of excitatory synaptic transmission in rat neostriatum

1995 • 116 citations

Dopamine release and uptake rates both decrease in the partially denervated striatum in proportion to the loss of dopamine terminals

1997 • 113 citations

Synaptic plasticity and physiological interactions between dopamine and glutamate in the striatum

1997 • 111 citations

Aromaticl-amino acid decarboxylase immunoreactive cells in the rat striatum: a possible site for the conversion of exogenousl-DOPA to dopamine

1995 • 111 citations

Oral levodopa dose‐response study in MPTP‐induced hemiparkinsonian monkeys: Assessment with a new rating scale for monkey parkinsonism

1991 • 111 citations

Short-Term increase and long-term reversion of striatal cell activity after degeneration of the nigrostriatal dopamine system

1978 • 110 citations

The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neurons

1990 • 109 citations

D-1 receptor supersensitivity in the rat striatum after unilateral 6-hydroxydopamine lesions

1986 • 107 citations

Factors that influence the occurrence of response variations in Parkinson's disease

1987 • 106 citations

Comparisons of therapeutic effects of levodopa, levodopa and selegiline, and bromocriptine in patients with early, mild Parkinson's disease: three year interim report. Parkinson's Disease Research Group in the United Kingdom.

1993 • 104 citations

Modeling N-methyl-d-aspartate-induced bursting in dopamine neurons

1996 • 103 citations

Developing a stable bilateral model of parkinsonism in rhesus monkeys

1993 • 103 citations

The in vivo microdialysis recovery of dopamine is altered independently of basal level by 6-hydroxydopamine lesions to the nucleus accumbens

1991 • 102 citations

Partial lesions of the nigrostriatal pathway in the rat Acceleration of transmitter synthesis and release of surviving dopaminergic neurones by drugs

1985 • 102 citations

The reciprocal electrophysiological influence between the nucleus tegmenti pedunculopontinus and the substantia nigra in normal and decorticated rats

1987 • 100 citations

Extensive loss of brain dopamine and serotonin induced by chronic administration of MPTP in the marmoset

1991 • 100 citations

Synaptic Concentration of Dopamine in the Mouse Striatum in Relationship to the Kinetic Properties of the Dopamine Receptors and Uptake Mechanism

1991 • 100 citations

Ultrastructural immunocytochemical localization of the dopamine D2 receptor within GABAergic neurons of the rat striatum

1997 • 98 citations

The cholinergic innervation of the rat substantia nigra: a light and electron microscopic immunohistochemical study

1988 • 97 citations

D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy

1988 • 95 citations

Chronic exposure to low doses of MPTP. II. Neurochemical and pathological consequences in cognitively-impaired, motor asymptomatic monkeys

1990 • 95 citations

Are presynaptic dopamine autoreceptors and postsynaptic dopamine receptors in the rabbit caudate nucleus pharmacologically different?

1982 • 94 citations

Dopaminergic sprouting in the rat striatum after partial lesion of the substantia nigra

1996 • 92 citations

Brain muscarinic receptors in senile dementia

1985 • 92 citations

Dopaminergic supersensitivity in the striatum.

1975 • 91 citations

Neural transplantation studies reveal the brain's capacity for continuous reconstruction

1997 • 91 citations

Homospecific activity (activity per enzyme protein) of tyrosine hydroxylase increases in parkinsonian brain

1988 • 88 citations

Concentration-dependent actions of stimulated dopamine release on neuronal activity in rat striatum

1990 • 87 citations

Supersensitivity to dopamine agonists following unilateral, 6-hydroxydopamine-induced striatal lesions in mice.

1975 • 87 citations

Administration of GMI. ganglioside restores the dopamine content in striatum after chronic treatment with MPTP

1986 • 86 citations

Effects of Frequency and Pattern of Medial Forebrain Bundle Stimulation on Caudate Dialysate Dopamine and Serotonin

1992 • 86 citations

Increased striatal dopamine efflux follows scopolamine administered systemically or to the tegmental pedunculopontine nucleus

1996 • 86 citations

L-Dopa (L-3,4-dihydroxyphenylanine)--its clinical effects in parkinsonism.

1968 • 85 citations

Long-term effects of dopamine-depleting brain lesions on spontaneous activity of type II striatal neurons: Relation to behavioral recovery

1986 • 85 citations

Alterations in consummatory behavior following intracisternal injection of 6-hydroxydopamine

1973 • 84 citations

Striatal neurons with aromatic l-amino acid decarboxylase-like immunoreactivity in the rat

1989 • 83 citations

Biochemistry of the hypothalamus in Parkinson's disease

1984 • 83 citations

Altered response to apomorphine in 6-hydroxydopamine-treated rats

1972 • 82 citations

Evidence that non-NMDA receptors are involved in the excitatory pathway from the pedunculopontine region to nigrostriatal dopaminergic neurons

1992 • 81 citations

Presynaptic regulation of dopaminergic transmission in the striatum

1988 • 81 citations

Long‐Term Induction of Tyrosine Hydroxylase Expression: Compensatory Response to Partial Degeneration of the Dopaminergic Nigrostriatal System in the Rat Brain

1995 • 81 citations

Neuroglial responses to the dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse striatum

1995 • 80 citations

Bromocriptine in Parkinson disease.

1985 • 80 citations

Glutamate induces the growth factors NGF, bFGF, the receptor FGF-R1 and c-fos mRNA expression in rat astrocyte culture

1993 • 79 citations

Presynaptic Control of the Synthesis and Release of Dopamine from Striatal Synaptosomes: A Comparison Between the Effects of 5‐Hydroxytryptamine, Acetylcholine, and Glutamate

1980 • 79 citations

Supersensitivity after intraventricular 6-hydroxydopamine: Relation to dopamine depletion

1980 • 78 citations

Kinetics of nigral degeneration in a chronic model of MPTP-treated mice

1997 • 76 citations

GM1 ganglioside-induced recovery of nigrostriatal dopaminergic neurons after MPTP: an immunohistochemical study

1989 • 76 citations

Changes of D1 and D2 receptors in adult rat neostriatum after neonatal dopamine denervation: Quantitative data from ligand binding,in situ hybridization and iontophoresis

1993 • 73 citations

Serotonergic sprouting in primate MTP-induced hemiparkinsonism

1993 • 72 citations

The regulation of dopamine release from nigrostriatal neurons in conscious rats: the role of somatodendritic autoreceptors

1991 • 71 citations

A morphological evidence for monosynaptic projections from the nucleus tegmenti pedunculopontinus pars compacta (TPC) to nigrostriatal projection neurons

1988 • 71 citations

Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease

1993 • 71 citations

Pharmacologically induced cessation of burst activity in nigral dopamine neurons: Significance for the terminal dopamine efflux

1994 • 70 citations

Short-term effects of dopamine-depleting brain lesions on spontaneous activity of striatal neurons: Relation to local dopamine concentration and behavior

1986 • 70 citations

Volume transmission of dopamine over large distances may contribute to recovery from experimental parkinsonism

1994 • 70 citations

Brain-derived neurotrophic factor works coordinately with partner molecules to initiate tyrosine hydroxylase expression in striatal neurons

1995 • 70 citations

Effects of GM1 ganglioside on developing and mature serotonin and noradrenaline neurons lesioned by selective neurotoxins

1984 • 67 citations

Tyrosine hydroxylase regulation in the central nervous system

1983 • 66 citations

Demonstration of l-dopa decarboxylating neurons specific to human striatum

1997 • 65 citations

The nigrostriatal dopaminergic system in MPTP-treated mice shows more prominent recovery by syngeneic adrenal medullary graft than by allogeneic or xenogeneic graft

1991 • 64 citations

Slow changes of tyrosine hydroxylase gene expression in dopaminergic brain neurons after neurotoxin lesioning: a model for neuron aging

1992 • 64 citations

Thalamotomy for the alleviation of levodopa-induced dyskinesia: Experimental studies in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated parkinsonian monkey

1993 • 63 citations

Immunocytochemical Quantification of Tyrosine Hydroxylase at a Cellular Level in the Mesencephalon of Control Subjects and Patients with Parkinson's and Alzheimer's Disease

1993 • 63 citations

Gliotoxic effects of α-aminoadipic acid on monolayer cultures of dissociated postnatal mouse cerebellum

1984 • 62 citations

Spontaneous recovery from motor asymmetry in adult rats with 6-hydroxydopamine-induced partial lesions of the substantia nigra

1984 • 62 citations

Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental Parkinsonism

1997 • 61 citations

Alleviation of behavioral deficits in aged rodents following implantation of encapsulated GDNF-producing fibroblasts.

1996 • 60 citations

Chemical anatomy of primate basal ganglia

1995 • 60 citations

GABA potentiates potassium-stimulated 3H-dopamine release from slices of rat substantia nigra and corpus striatum

1978 • 60 citations

Effects of Nigrostriatal Denervation and L‐Dopa Therapy on the GABAergic Neurons of the Striatum in MPTP‐treated Monkeys and Parkinson's Disease: An In Situ Hybridization Study of GAD₆₇ mRNA

1995 • 59 citations

Striatal phosphoproteins in Parkinson disease and progressive supranuclear palsy.

1989 • 59 citations

Serotonin Stimulation of 5‐HT₄ Receptors Indirectly Enhances In Vivo Dopamine Release in the Rat Striatum

1997 • 59 citations

MPTP induced hemiparkinsonism in monkeys: behavioral, mechanographic, electromyographic and immunohistochemical studies

1992 • 59 citations

Influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopaminergic neurons in rat substantia nigra.

1994 • 58 citations

A mathematical model of pathogenesis in idiopathic parkinsonism

1994 • 58 citations

A light and electron microscopical study of enkephalin-immunoreactive structures in the rat neostriatum after removal of the nigrostriatal dopaminergic pathway

1991 • 56 citations

Electrophysiological and pharmacological evidence for the existence of distinct subpopulations of nigrostriatal dopaminergic neuron in the rat

1988 • 55 citations

Dopamine D‐1 Receptor and Cyclic AMP‐Dependent Phosphorylation in Parkinson's Disease

1987 • 55 citations

Plasticity after brain lesions: contemporary concepts.

1988 • 54 citations

The time course and magnitude of spontaneous recovery of parkinsonism produced by intracarotid administration of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐tetrahydropyridine to monkeys

1991 • 54 citations

Activation of mesencephalic dopamine neurons by chemical stimulation of the nucleus tegmenti pedunculopontinus pars compacta

1988 • 54 citations

Alleviation of behavioral deficits in aged rodents following implantation of encapsulated GDNF-producing fibroblasts

1996 • 53 citations

Intrastriatal Dopamine‐rich Implants Reverse the Increase of Dopamine D₂ Receptor mRNA Levels Caused by Lesion of the Nigrostriatal Pathway: A Quantitative In Situ Hybridization Study

1992 • 52 citations

Dopamine receptor ‘supersensitivity’ occurring without receptor up-regulation

1991 • 52 citations

Comparison of therapeutic effects of levodopa, levodopa and selegiline, and bromocriptine in patients with early, mild Parkinson’s disease: three year interim report

1993 • 52 citations

Intranigral or intrastriatal injections of GDNF: effects on monoamine levels and behavior in rats

1996 • 51 citations

GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys

1993 • 51 citations

Self-inhibition by dopaminergic neurones: Disruption by (±)-α-methyl-p-tyrosine pretreatment or anterior diencephalic lesions

1976 • 50 citations

Dopaminergic agonists in the treatment of Parkinson's disease.

1990 • 49 citations

Striatal D1 dopamine receptor distribution following chemical lesion of the nigrostriatal pathway

1988 • 49 citations

Changes of D1 and D2 dopamine receptor mRNA in the brains of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: correction with chronic administration of L-3,4-dihydroxyphenylalanine.

1996 • 49 citations

Chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to monkeys: Behavioural, morphological and biochemical correlates

1993 • 47 citations

Increase in striatal dopamine D2 receptor mRNA after lesions of haloperidol treatment

1990 • 46 citations

Response of caudate neurons to stimulation of intrinsic and peripheral afferents in normal, symptomatic, and recovered MPTP-treated cats

1993 • 46 citations

Expression of glial cell line-derived neurotrophic factor (GDNF) mRNA following mechanical injury to mouse striatum

1997 • 46 citations

D1–D2 Interaction in Feedback Control of Midbrain Dopamine Neurons

1997 • 46 citations

A pharmacological analysis of the burst events induced in midbrain dopaminergic neurons by electrical stimulation of the prefrontal cortex in the rat

1996 • 45 citations

Role of dynorphin-containing neurons in the presynaptic inhibitory control of the acetylcholine-evoked release of dopamine in the striosomes and the matrix of the cat caudate nucleus

1991 • 44 citations

PET studies of functional compensation in a primate model of Parkinsonʼs disease

1997 • 44 citations

Dopamine‐Glutamate‐GABA Interactions and Ageing: Studies in the Striatum of the Conscious Rat

1995 • 44 citations

Biology of Glial Cell Line-derived Neurotrophic Factor (GDNF): Implications for the Use of GDNF to Treat Parkinson's Disease

1996 • 43 citations

Sham transplantation protects against 6-hydroxydopamine-induced dopaminergic toxicity in rats: behavioral and morphological evidence

1991 • 43 citations

Evidence for volume transmission in the dopamine denervated neostriatum of the rat after a unilateral nigral 6-OHDA microinjection. Studies with systemic d-amphetamine treatment

1994 • 43 citations

Plasticity of nerve afferents to nigrostriatal neurons in parkinson's disease

1995 • 42 citations

A rationale for monoamine oxidase inhibition as neuroprotective therapy for parkinson's disease

1993 • 42 citations

A cholinergic input to the substantia nigra pars compacta increases striatal dopamine metabolism measured by in vivo voltammetry

1992 • 41 citations

Behavioral correlates of dopaminergic supersensitivity.

1975 • 41 citations

Effects of a novel differentiation factor on the development of catecholamine traits in noncatecholamine neurons from various regions of the rat brain: studies in tissue culture

1991 • 41 citations

Endogenous Dopamine Functionally Activates D‐1 and D‐2 Receptors in Striatum

1987 • 40 citations

Functional and Molecular Differentiation of the Dopamine System Induced by Neonatal Denervation

1996 • 39 citations

Motor and nonmotor behavioral deficits in monkeys made hemiparkinsonian by intracarotid MPTP infusion

1992 • 36 citations

Effects of haloperidol on the activity and membrane physiology of substantia nigra dopamine neurons recorded in vitro

1996 • 35 citations

Changes in the retention and metabolism of 3 H-l-norepinephrine in rat brain in vivo after 6-hydroxydopamine pretreatment.

1971 • 35 citations

Investigation of possible interactions between substance P and transmitter mechanisms in the substantia nigra and corpus striatum of the rat

1978 • 34 citations

Synaptosomal uptake and release of dopamine in substantia nigra: Effects of γ-aminobutyric acid and substance P

1979 • 34 citations

Central dopaminergic neurons: Neurophysiological identification and responses to drugs

1973 • 34 citations

Differential Actions of Endogenous and Iontophoretic Dopamine in Rat Striatum

1990 • 33 citations

Expression and distribution of two isoforms of tyrosine hydroxylase in macaque monkey brain

1994 • 33 citations

Therapeutic Potential of AMPA Receptor Ligands in Neurological Disorders

1996 • 31 citations

Effects of nicotine on dopaminergic nigrostriatal axons requires stimulation of presynaptic glutamatergic receptors.

1996 • 30 citations

Striatal Homogenates from Animals Chronically Treated with Haloperidol Stimulate Dopamine and GABA Uptake in Cultures of Rostral Mesencephalic Tegmentum

1989 • 30 citations

Functional heterogeneity of the matrix compartment in the cat caudate nucleus as demonstrated by the cholinergic presynaptic regulation of dopamine release

1992 • 29 citations

Presymptomatic revelation of experimental Parkinsonism

1997 • 29 citations

Striatal expression of substance P and methionin-enkephalin genes in patients with Parkinson's disease

1995 • 28 citations

Short- and long-term changes in striatal and extrastriatal dopamine uptake sites in the MPTP-treated common marmoset

1995 • 26 citations

Lack of change in striatal DARPP-32 levels following nigrostriatal dopaminergic lesions in animals and in parkinsonian syndromes in man

1990 • 26 citations

DA Uptake Sites, D₁, and D₂ Receptors, D₂ and Preproenkephalin mRNAs and Fos Immunoreactivity in Rat Striatal Subregions after Partial Dopaminergic Degeneration

1996 • 25 citations

Rate and Duration of Stimulation Determine Presynaptic Effects of Haloperidol on Dopaminergic Neurons

1982 • 25 citations

Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons

1996 • 23 citations

Sustained low-dose levodopa therapy in Parkinson's disease: a 3-year follow-up.

1983 • 23 citations

Acute effects of intranigral application of MPP+ on nigral and bilateral striatal release of dopamine simultaneously recorded by microdialysis

1991 • 23 citations

Some neurons of the mouse cortex and caudoputamen contain aromatic L-amino acid decarboxylase but not monoamines.

1991 • 23 citations

Delayed plasticity of the mesolimbic dopamine system following neonatal 6-OHDA lesions

1997 • 21 citations

Spontaneous activity of Type II but not Type I striatal neurons is correlated with recovery of behavioral function after dopamine-depleting brain lesions

1988 • 20 citations

N-Methyl-d-aspartate receptors mediate a slow excitatory postsynaptic potential in the rat midbrain dopaminergic neurons

1996 • 20 citations

Dopaminergic supersensitivity in parkinsonism.

1975 • 19 citations

Electrophysiological effects of monoamine oxidase inhibition on rat midbrain dopaminergic neurones: an in vitro study

1996 • 18 citations

Possible intermixing of neurons from the subthalamic nucleus and substantia nigra pars compacta in the guinea-pig

1995 • 18 citations

Cortical ablation reduces veratridine evoked release of endogenous glutamate from superfused substantia nigra slices

1991 • 18 citations

Intranigral substance P stimulation of striatal dopamine release is inhibited by Spantide II: a new tachykinin antagonist without apparent neurotoxicity

1990 • 18 citations

Effects of subthalamic nucleus lesions in a putative model of tardive dyskinesia in the rat

1996 • 17 citations

Dopaminergic terminal excitability following arrival of the nerve impulse: The influence of amphetamine and haloperidol

1982 • 16 citations

Glutamatergic compensatory mechanisms in experimental parkinsonism

1998 • 15 citations

Levodopa Substitution: The Gold Standard

1994 • 15 citations

Dopaminergic responses to striatal damage.

1996 • 14 citations

Is dopaminergic cell death accompanied by concomitant nerve plasticity?

1996 • 14 citations

Surgical damage stimulates proliferation of dopamine uptake sites in normal mouse brain

1993 • 14 citations

Morphological and biochemical adaptations to unilateral dopamine denervation of the neostriatum in newborn rats

1997 • 12 citations

Chronic administration of MPTP to monkeys: Behavioural morphological and biochemical correlates

1992 • 11 citations

Haloperidol-induced alteration of post-firing inhibition in dopaminergic neurons of rat substantia nigra

1979 • 11 citations

Low affinity nerve growth factor receptor, adrenal transplant and Parkinson's disease

1993 • 9 citations

Dopaminergic responses to striatal damage

1996 • 6 citations

Effects of various experimental manipulations on neostriatal acetylcholine and dopamine release

1991 • 5 citations

Neurobehavioral functions of residual striatal DA in rats treated with 6-OHDA as weanlings vs. as adults

1997 • 1 citations