The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

Is Type II diabetes mellitus a disease of the innate immune system?

1998 • 1,040 citations

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

1990 • 1,002 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

The Role of Inflammatory Cytokines in Diabetic Nephropathy

2008 • 867 citations

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

1993 • 819 citations

Cytokine and Cytokine-Like Inflammation Markers, Endothelial Dysfunction, and Imbalanced Coagulation in Development of Diabetes and Its Complications

2009 • 613 citations

Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition

2009 • 599 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes

2000 • 554 citations

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

1993 • 525 citations

Transforming growth factor‐β and Smad signalling in kidney diseases

2005 • 336 citations

From Fibrosis to Sclerosis

2008 • 305 citations

IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

2010 • 250 citations

Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases

2011 • 237 citations

Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation

2006 • 201 citations

Elevated Levels of the Anti-Inflammatory Interleukin-1 Receptor Antagonist Precede the Onset of Type 2 Diabetes

2008 • 199 citations

Intron-exon structure of the human transforming growth factor-β precursor gene

1987 • 159 citations

PDGF and TGF-β contribute to the natural course of human IgA glomerulonephritis

1995 • 122 citations

Markers of Endothelial Dysfunction and Inflammation in Type 1 Diabetic Patients With or Without Diabetic Nephropathy Followed for 10 Years

2008 • 116 citations

Diabetes, Inflammation, Proinflammatory Cytokines, and Diabetic Nephropathy

2006 • 106 citations

Risk Factors Related to Inflammation and Endothelial Dysfunction in the DCCT/EDIC Cohort and Their Relationship With Nephropathy and Macrovascular Complications

2008 • 100 citations

Transforming Growth Factor-β1 Increases the Expression of Lectin-like Oxidized Low-Density Lipoprotein Receptor-1

2000 • 95 citations

Comparison of serum concentrations of soluble adhesion molecules in diabetic microangiopathy and macroangiopathy

2002 • 94 citations

Both ERK/MAPK and TGF-Beta/Smad Signaling Pathways Play a Role in the Kidney Fibrosis of Diabetic Mice Accelerated by Blood Glucose Fluctuation

2013 • 90 citations

A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-β1 (TGF-β1) and its signaling pathway

2002 • 86 citations

Association of TGFβ1, TNFα, CCR2 and CCR5 gene polymorphisms in type-2 diabetes and renal insufficiency among Asian Indians

2007 • 85 citations

Common Variants of Inflammatory Cytokine Genes Are Associated with Risk of Nephropathy in Type 2 Diabetes among Asian Indians

2009 • 82 citations

Cytokines in diabetic nephropathy

2012 • 65 citations

Association of transforming growth factor-beta (TGF-β) T869C (Leu 10Pro) gene polymorphisms with type 2 diabetic nephropathy in Chinese

2003 • 53 citations

Predictive value of cytokine gene polymorphisms for the development of end-stage renal disease.

2006 • 38 citations

Hypercholesterolemia leads to elevated TGF-β1 activity and T helper 3-dependent autoimmune responses in atherosclerotic mice

2008 • 35 citations

Gene polymorphism of transforming growth factor-β1 in Egyptian patients with type 2 diabetes and diabetic nephropathy

2013 • 35 citations

Transforming growth factor beta activity in urine of patients with type 2 diabetes and diabetic nephropathy

1999 • 30 citations

TGF-β1 and TSC-22 Gene Polymorphisms and Susceptibility to Microvascular Complications in Type 2 Diabetes

2007 • 29 citations

Association of polymorphisms within the transforming growth factor‐β1 gene with diabetic nephropathy and serum cholesterol and triglyceride concentrations

2010 • 28 citations

Association of transforming growth factor-β1 T29C polymorphism with the progression of diabetic nephropathy

2001 • 27 citations

Association between the T869C polymorphism of transforming growth factor-beta 1 and diabetic nephropathy: a meta-analysis

2011 • 23 citations

IHG-1 amplifies TGF-β1 signalling and mitochondrial biogenesis and is increased in diabetic kidney disease

2012 • 16 citations

Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism

2011 • 16 citations

Inhibition of TGF-β expression: A novel role for thiazolidinediones to implement renoprotection in diabetes

2007 • 12 citations