Genetics of diabetic nephropathy

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

1990 • 3,809 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

The Wisconsin Epidemiologic Study of Diabetic Retinopathy

1984 • 1,871 citations

The Wisconsin Epidemiologic Study of Diabetic Retinopathy

1984 • 1,455 citations

Albuminuria reflects widespread vascular damage

1989 • 1,390 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Diabetic nephropathy in type 1 (insulin-dependent) diabetes: An epidemiological study

1983 • 1,078 citations

Familial Clustering of Diabetic Kidney Disease

1989 • 991 citations

The changing natural history of nephropathy in type I Diabetes

1985 • 792 citations

Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

1994 • 731 citations

Predisposition to Hypertension and Susceptibility to Renal Disease in Insulin-Dependent Diabetes Mellitus

1988 • 650 citations

The effect of proteinuria on relative mortality in Type 1 (insulin-dependent) diabetes mellitus

1985 • 611 citations

Linkage of the Angiotensinogen Gene to Essential Hypertension

1994 • 579 citations

A smoking–dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene

1996 • 571 citations

Familial factors determine the development of diabetic nephropathy in patients with IDDM

1996 • 455 citations

Relationships Between Angiotensin I Converting Enzyme Gene Polymorphism, Plasma Levels, and Diabetic Retinal and Renal Complications

1994 • 361 citations

Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes. Pima Diabetes Genes Group.

1998 • 332 citations

Raised arterial pressure in parents of proteinuric insulin dependent diabetics.

1987 • 308 citations

Is diabetic nephropathy an inherited complication?

1992 • 303 citations

Insulin resistance in insulin-dependent diabetic patients with microalbuminuria

1993 • 249 citations

Insulin resistance, hypertension and microalbuminuria in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1993 • 246 citations

Clustering of Long-Term Complications in Families With Diabetes in the Diabetes Control and Complications Trial

1997 • 239 citations

Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy

1998 • 236 citations

Familial Clustering of Cardiovascular Disease in Patients with Insulin-Dependent Diabetes and Nephropathy

1992 • 223 citations

Linkage of Genetic Markers on Human Chromosomes 20 and 12 to NIDDM in Caucasian Sib Pairs With a History of Diabetic Nephropathy

1997 • 214 citations

Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism

2000 • 194 citations

Diabetic Retinopathy in Identical Twins

1973 • 193 citations

Prognosis in diabetic nephropathy.

1989 • 193 citations

Lack of Relationship Between an Insertion/Deletion Polymorphism in the Angiotensin I–Converting Enzyme Gene and Diabetic Nephropathy and Proliferative Retinopathy in IDDM Patients

1995 • 187 citations

Genetic Predisposition to Diabetic Nephropathy: Evidence for a Role of the Angiotensin I–Converting Enzyme Gene

1994 • 185 citations

Association of ACE gene polymorphism and diabetic nephropathy?

1995 • 180 citations

Effect of deletion polymorphism of angiotensin converting enzyme gene on progression of diabetic nephropathy during inhibition of angiotensin converting enzyme: observational follow up study

1996 • 179 citations

Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy

1996 • 170 citations

Major susceptibility locus for nephropathy in type 1 diabetes on chromosome 3q: results of novel discordant sib-pair analysis.

1998 • 169 citations

Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients: findings from the EUCLID Randomized Controlled Trial. EURODIAB Controlled Trial of Lisinopril in IDDM.

1998 • 158 citations

Serum paraoxonase activity and its relationship to diabetic complications in patients with non—insulin-dependent diabetes mellitus

1998 • 153 citations

Interleukin-1 receptor antagonist allele (ILIRN*2) associated with nephropathy in diabetes mellitus

1996 • 150 citations

Polymorphism in the 5′-End of the Aldose Reductase Gene Is Strongly Associated With the Development of Diabetic Nephropathy in Type I Diabetes

1997 • 143 citations

Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes.

2000 • 131 citations

How to Protect the Kidney in Diabetic Patients: With Special Reference to IDDM

1997 • 113 citations

Prognostic Value of Angiotensin-I Converting Enzyme I/D Polymorphism for Nephropathy in Type 1 Diabetes Mellitus

2001 • 109 citations

Association between the angiotensin-converting enzyme-insertion/deletion polymorphism and diabetic nephropathy

1998 • 108 citations

APOE polymorphisms and the development of diabetic nephropathy in type 1 diabetes: results of case-control and family-based studies.

2000 • 108 citations

Predisposition to hypertension: Risk factor for nephropathy and hypertension in IDDM

1992 • 106 citations

Genetic linkage analysis of growth factor loci and end-stage renal disease in African Americans

1997 • 80 citations

Z−2 Microsatellite Allele Is Linked to Increased Expression of the Aldose Reductase Gene in Diabetic Nephropathy1

1998 • 80 citations

Aldose reductase gene polymorphisms and susceptibility to diabetic nephropathy in Type 1 diabetes mellitus

2000 • 78 citations

Do genetic factors play a role in the pathogenesis of diabetic microangiopathy?

1984 • 78 citations

A Molecular Variant of Angiotensinogen Is Associated With Diabetic Nephropathy in IDDM

1996 • 77 citations

Association of Apolipoprotein ε2 Allele With Diabetic Nephropathy in Caucasian Subjects With IDDM

1998 • 76 citations

High prevalence of risk factors for cardiovascular disease in parents of IDDM patients with albuminuria

1997 • 68 citations

Angiotensinogen Gene Polymorphisms in IDDM Patients With Diabetic Nephropathy

1996 • 66 citations

A Variant of Paraoxonase (PON1) Gene Is Associated with Diabetic Retinopathy in IDDM

1998 • 65 citations

Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM

1996 • 63 citations

Association of an (A-C)n dinucleotide repeat polymorphic marker at the 5'-region of the aldose reductase gene with retinopathy but not with nephropathy or neuropathy in Japanese patients with Type 2 diabetes mellitus

1999 • 61 citations

Parental history of hypertension and parental history of diabetes and microvascular complications in insulin-dependent diabetes mellitus: the EURODIAB IDDM complications study

1998 • 61 citations

Synergistic effect of angiotensin II type 1 receptor genotype and poor glycaemic control on risk of nephropathy in IDDM

1997 • 59 citations

Apolipoprotein E genotypes and risk of diabetic nephropathy.

1996 • 58 citations

AN INTERLUEKIN 1B ALLELE, WHICH CORRELATES WITH A HIGH SECRETOR PHENOTYPE, IS ASSOCIATED WITH DIABETIC NEPHROPATHY

1998 • 56 citations

Apolipoprotein E Polymorphism and Renal Function in German Type 1 and Type 2 Diabetic Patients

1998 • 55 citations

Linkage analysis between loci in the renin-angiotensin axis and end-stage renal disease in African Americans.

1996 • 55 citations

The role of aldose reductase gene in the susceptibility to diabetic nephropathy in Type II (non-insulin-dependent) diabetes mellitus (Short Communication)

1999 • 49 citations

Diabetic nephropathy is not associated with the dinucleotide repeat polymorphism upstream of the aldose reductase (ALR2) gene but with erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes.

1999 • 44 citations

Angiotensinogen gene M235T polymorphism is not associated with diabetic nephropathy

1996 • 41 citations

Elevated serum angiotensin I converting enzyme activity in type I, insulin-dependent diabetic subjects with persistent microalbuminuria

1992 • 39 citations

Methylenetetrahydrofolate Reductase Gene Polymorphism as a Risk Factor for Diabetic Nephropathy in IDDM Patients

1999 • 37 citations

Angiotensin II type 1 receptor gene polymorphism and the response to hyperglycemia in early type 1 diabetes.

2000 • 37 citations

Genetic Variation of the Heparan Sulfate Proteoglycan Gene (Perlecan Gene): Association With Urinary Albumin Excretion in IDDM Patients

1997 • 37 citations

Lack of relationship in long‐term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein ε, lipoprotein lipase and cholesteryl ester transfer protein

2000 • 37 citations

Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in Type I diabetes mellitus

2000 • 36 citations

Lack of Association Between an ecNOS Gene Polymorphism and Diabetic Nephropathy in Type 2 Diabetic Patients with Proliferative Diabetic Retinopathy

2000 • 35 citations

Angiotensin-II type 1 receptor gene polymorphism and diabetic microangiopathy

1996 • 35 citations

Lack of synergism between long-term poor glycaemic control and three gene polymorphisms of the renin angiotensin system on risk of developing diabetic nephropathy in Type I diabetic patients

2000 • 29 citations

Lack of association of angiotensin II type 1 receptor gene polymorphism with diabetic nephropathy in insulin-dependent diabetes mellitus

1997 • 28 citations

The C825T polymorphism in the human G-protein β3 subunit gene is not associated with diabetic nephropathy in Type I diabetes mellitus

1998 • 26 citations

Polymorphisms in the Interleukin-1 Gene Cluster Do Not Contribute to the Genetic Susceptibility of Diabetic Nephropathy in Caucasian Patients With IDDM

1997 • 26 citations

Angiotensin-II type 1 receptor gene polymorphism and diabetic microangiopathy

1996 • 25 citations

Angiotensinogen gene M235T polymorphism is not associated with diabetic nephropathy

1996 • 24 citations

Pronatriodilatin Gene Polymorphisms, Microvascular Permeability, and Diabetic Nephropathy in Type 1 Diabetes Mellitus

1999 • 17 citations

A polymorphism in the gene for the atrial natriuretic peptide and diabetic nephropathy

1998 • 16 citations

Risk of developing diabetic nephropathy is not associated with synergism between the angiotensin II (type 1) receptor C1166 allele and poor glycaemic control

1999 • 15 citations

N-Acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathy

1999 • 10 citations