Protein kinase C‐activating phorbol esters augment expression of T cell receptor genes

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Thymoma production of T cell growth factor (Interleukin 2).

1980 • 487 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin A

1984 • 404 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.

1984 • 331 citations

Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C.

1983 • 291 citations

The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor

1984 • 290 citations

Cyclosporin A Binding to Calmodulin: A Possible Site of Action on T Lymphocytes

1985 • 282 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C

1985 • 255 citations

Structure of wild-type and mutant mouse β2-microglobulin genes

1982 • 230 citations

Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen.

1984 • 227 citations

Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells.

1984 • 225 citations

Macrophage-independent activation of helper T cells. I. Production of Interleukin 2.

1980 • 219 citations

Phorbol myristate acetate: a mitogen selective for a T-lymphocyte subpopulation.

1977 • 188 citations

Stimulation of the Na/H exchanger of sea urchin eggs by phorbol ester

1985 • 160 citations

The Human T-Cell Receptor

1985 • 152 citations

Association of protein kinase C activation with IL 2 receptor expression.

1986 • 146 citations

Lymphocyte Activation by the Tumor-Promoting Agent 12-O-Tetradecanoylphorbol-13-Acetate (TPA)

1979 • 145 citations

Signal transduction and intracellular events in T-lymphocyte activation

1986 • 134 citations

Induction of expression and phosphorylation of the human interleukin 2 receptor by a phorbol diester.

1984 • 116 citations

Antigen-dependent increase in cytosolic free calcium in specific human T-lymphocyte clones

1985 • 92 citations

Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes.

1985 • 83 citations

Transmembrane signalling by the T3-antigen receptor complex

1985 • 82 citations

Delineation of a defect in T cell receptor beta genes of NZW mice predisposed to autoimmunity.

1986 • 68 citations

Affinity alteration of insulin receptor induced by a phorbol ester

1982 • 65 citations

Cyclosporin A inhibits antigen‐ and lectin‐induced but not constitutive production of interleukin 3

1985 • 36 citations

The tumor promoter teleocidin induces IL 2 receptor expression and IL 2-independent proliferation of human peripheral blood T cells.

1985 • 29 citations

Tolerance in T-cell clones

1985 • 28 citations

Negative trans-regulation of T-cell antigen receptor/T3 complex mRNA expression in murine T-lymphoma somatic cell hybrids.

1986 • 27 citations

Interleukin 2 mRNA induction in human lymphocytes: analysis of the synergistic effect of a calcium ionophore A23187 and a phorbol ester

1985 • 26 citations

Teleocidin and phorbol ester tumor promoters exert similar mitogenic effects on human lymphocytes

1985 • 22 citations