Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis.

Lymphocyte responses and cytokines

1994 • 1,860 citations

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

Molecular mimicry and autoimmune disease

1987 • 943 citations

Development of Arthritis, Periarthritis and Periostitis in Rats Given Adjuvants.

1956 • 847 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.

1989 • 492 citations

Arthritis in rats after systemic injection of streptococcal cells or cell walls.

1977 • 437 citations

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 • 384 citations

Stress proteins may provide a link between the immune response to infection and autoimmunity

1989 • 264 citations

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein.

1989 • 237 citations

Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein.

1989 • 211 citations

Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis.

1992 • 200 citations

Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis

1991 • 199 citations

A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic.

1990 • 188 citations

Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.

1993 • 158 citations

Effect of adjuvant therapy on development of diabetes in mouse and man

1994 • 157 citations

Adjuvant polyarthritis iv. induction by a synthetic adjuvant: immunologic, histopathologic, and other studies

1980 • 146 citations

Primary Structure of a Human Mitochondrial Protein Homologous to the Bacterial and Plant Chaperonins and to the 65-Kilodalton Mycobacterial Antigen

1989 • 144 citations

Autoimmune reactions to heat‐shock proteins in pristane‐induced arthritis

1990 • 140 citations

Presence of Human 65 kD Heat Shock Protein (hsp) in Inflamed Joints and Subcutaneous Nodules of RA Patients

1990 • 135 citations

Peptide recognition, T cell receptor usage and HLA restriction elements of human heat‐shock protein (hsp) 60 and mycobacterial 65‐kDa hsp‐reactive T cell clones from rheumatoid synovial fluid

1992 • 118 citations

Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols.

1994 • 110 citations

Susceptibility to adjuvant-induced arthritis among germfree, specific-pathogen-free, and conventional rats

1979 • 106 citations

Inflammation activates self hsp60‐specific T cells

1993 • 89 citations

Suppressive effect of Escherichia coli on adjuvant‐induced arthritis in germ‐free rats

1986 • 77 citations

Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat-shock protein

1990 • 50 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 45 citations

Adjuvant arthritis and immunity to the mycobacterial 65 kDa heat shock protein

1992 • 39 citations

Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat shock protein: specificity and mechanism

1992 • 38 citations

A Monoclonal Antibody to the Mycobacterial 65kDa Heat Shock Protein (ML 30) Binds to Cells in Normal and Arthritic Joints of Rats

1991 • 25 citations