Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling

Transcriptional regulation by the phosphorylation-dependent factor CREB

2001 • 2,488 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

2001 • 1,351 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Ten years of protein kinase B signalling: a hard Akt to follow

2001 • 1,159 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

2005 • 945 citations

SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2

2002 • 874 citations

Insulin Signaling in Health and Disease

2003 • 700 citations

Calorie restriction and aging: review of the literature and implications for studies in humans

2003 • 691 citations

The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector

2004 • 633 citations

Control of cell number byDrosophilaFOXO: downstream and feedback regulation of the insulin receptor pathway

2003 • 596 citations

TORCs

2003 • 583 citations

PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3

2004 • 545 citations

cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2

2003 • 541 citations

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

2000 • 519 citations

A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos

1998 • 502 citations

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

2000 • 499 citations

Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells

2003 • 362 citations

Life Extension in the Dwarf Mouse

2004 • 333 citations

SREBPs suppress IRS-2-mediated insulin signalling in the liver

2004 • 310 citations

CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ

2003 • 293 citations

Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

2005 • 273 citations

Genome-Wide Analysis of CREB Target Genes Reveals A Core Promoter Requirement for cAMP Responsiveness

2003 • 253 citations

Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling

2004 • 217 citations

Effects of weight loss on insulin secretion and in vivo insulin sensitivity in obese diabetic and non-diabetic subjects.

2004 • 26 citations