Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

PCR protocols — A guide to methods and applications

1990 • 12,897 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits

1991 • 1,076 citations

Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure

1989 • 745 citations

Identification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection

1990 • 695 citations

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.

1986 • 581 citations

The enzymatic preparation of [α-32P]nucleoside triphosphates, cyclic [32P]AMP, and cyclic [32P]GMP

1979 • 574 citations

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

1987 • 524 citations

Relationship between the beta-adrenergic receptor and adenylate cyclase.

1977 • 497 citations

Human cDNA clones for four species of G alpha s signal transduction protein.

1986 • 370 citations

Cloning and expression of a widely distributed (type IV) adenylyl cyclase.

1991 • 363 citations

Selection of a Variant Lymphoma Cell Deficient in Adenylate Cyclase

1975 • 276 citations

Isolation and characterization of a novel cardiac adenylylcyclase cDNA.

1992 • 263 citations

Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells.

1992 • 262 citations

Purification of the catalyst of adenylate cyclase.

1986 • 259 citations

Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclases. Purification of the human erythrocyte proteins without the use of activating regulatory ligands.

1984 • 242 citations

Adenylyl Cyclase Activities in Ovarian Tissues. I. Homogenization and Conditions of Assay in Graafian Follicles and Corpora Lutea of Rabbits, Rats, and Pigs: Regulation by ATP, and Some Comparative Properties

1976 • 218 citations

Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins.

1985 • 206 citations

Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family.

1992 • 201 citations

Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase.

1986 • 177 citations

Guanylyl cyclases, a growing family of signal‐transducing enzymes

1991 • 168 citations

Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.

1988 • 144 citations

Somatic genetic analysis of cyclic AMP action: Selection of unresponsive mutants

1975 • 132 citations

Glucagon-induced heterologous desensitization of the MDCK cell adenylyl cyclase. Increases in the apparent levels of the inhibitory regulator (Ni).

1984 • 119 citations

Different mechanisms of desensitization of adenylate cyclase by isoproterenol and prostaglandin E1 in human fibroblasts. Role of regulatory components in desensitization.

1982 • 115 citations

Identification of a specific site required for rapid heterologous desensitization of the beta-adrenergic receptor by cAMP-dependent protein kinase.

1989 • 115 citations

Kinase-negative mutants of S49 mouse lymphoma cells carry a trans-dominant mutation affecting expression of cAMP-dependent protein kinase

1978 • 99 citations

Hysteretic activation of adenylyl cyclases. II. Mg ion regulation of the activation of the regulatory component as analyzed by reconstitution.

1981 • 75 citations

Human Chorionic Gonadotropin-Induced Heterologous Desensitization of Adenylyl Cyclase from Highly Luteinized Rat Ovaries: Attenuation of Regulatory N Component Activity^*

1983 • 49 citations

β‐Adrenergic receptor desensitization of wild‐type but not cyc lymphoma cells unmasked by submillimolar Mg ²⁺

1987 • 42 citations

Cell‐free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP‐dependent protein kinase

1989 • 35 citations

Glucagon-induced desensitization of adenylyl cyclase in primary cultures of chick hepatocytes. Evidence for multiple pathways.

1988 • 31 citations

Chemical and functional analysis of components of adenylyl cyclase from human platelets treated with phorbolesters

1991 • 30 citations