Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein

1992 • 1,559 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

Oxidative Stress in Neurodegenerative Diseases

1996 • 1,336 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

[23] Oxidative chemistry of peroxynitrite

1994 • 981 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1993 • 679 citations

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

1996 • 630 citations

Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution

1985 • 512 citations

Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products

1984 • 394 citations

Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids

1986 • 374 citations

Tyrosine Modification by Reactive Nitrogen Species: A Closer Look

1995 • 371 citations

Paradoxical fate and biological action of peroxynitrite on human platelets.

1994 • 364 citations

Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide

1996 • 355 citations

One- and two-electron oxidations of methionine by peroxynitrite.

1994 • 318 citations

Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion

1994 • 287 citations

Nitric Oxide Regulation of Tissue Free Radical Injury

1996 • 278 citations

Reversible Binding and Inhibition of Catalase by Nitric Oxide

1995 • 277 citations

Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major

1994 • 264 citations

DNA strand breakage and activation of poly-ADP ribosyltransferase: A cytotoxic pathway triggered by peroxynitrite

1996 • 257 citations

Intracranial microdialysis of salicylic acid to detect hydroxyl radical generation through dopamine autooxidation in the caudate nucleus: Effects of MPP+

1992 • 234 citations

On the pH-dependent yield of hydroxyl radical products from peroxynitrite

1994 • 202 citations

Oxygen radicals, nitric oxide and human inflammatory joint disease.

1995 • 185 citations

Promotion of Fibroblast Adhesion by Triple-helical Peptide Models of Type I Collagen-derived Sequences

1996 • 176 citations

Direct and indirect oxidations by peroxynitrite, neither involving the hydroxyl radical

1996 • 140 citations

Desferrioxamine inhibition of the hydroxyl radical-like reactivity of peroxynitrite: Role of the hydroxamic groups

1995 • 123 citations

On the limited ability of superoxide to release iron from ferritin

1990 • 114 citations

Role of nitric oxide in neurodegenerative diseases

1995 • 108 citations

Susceptibility ofBrugia malayiandOnchocerca lienalismicrofilariae to nitric oxide and hydrogen peroxide in cell-free culture and from IFNγ-activated macrophages

1996 • 100 citations

Reactive oxygen intermediates as second messengers of a general pathogen response.

1996 • 98 citations

Versatility and low-temperature synthetic potential of ammonium halides

1985 • 93 citations

Evidence for the formation of hydroxyl radicals in the isomerization of pernitrous acid to nitric acid in aqueous solution

1970 • 88 citations

Does peroxynitrite generate hydroxyl radical?

1995 • 75 citations

Reaction between Peroxynitrite and Hydrogen Peroxide: Formation of Oxygen and Slowing of Peroxynitrite Decomposition

1995 • 71 citations

Catalase inhibits nitric oxide synthesis and the killing of intracellular Leishmania major in murine macrophages

1992 • 53 citations

Oxygen Free Radicals and Neurodegeneration in Parkinson's Disease: A Role for Nitric Oxide^a

1994 • 48 citations

Determination of hydroxylated aromatic compounds produced via superoxide-dependent formation of hydroxyl radicals by liquid chromatography/electrochemistry

1983 • 47 citations

ESR Spin Trapping Investigation on Peroxynitrite Decomposition: No Evidence for Hydroxyl Radical Production

1994 • 44 citations

Nitric oxide reduces hydrogen peroxide production from human polymorphonuclear neutrophils

1995 • 42 citations

Reduction by N^G‐nitro‐L‐arginine of H₂O₂‐induced endothelial cell injury

1994 • 36 citations

The Effects of Hydroxyl Radical Attack on Dopa, Dopamine, 6‐Hydroxydopa, and 6‐Hydroxydopamine

1995 • 35 citations

Hydroxyl Free Radical (·OH) Formation Reflected by Salicylate Hydroxylation and Neuromelanin

1993 • 35 citations

Reactions of Nitric Oxide and Hydrogen Peroxide with Hemoglobin‐Based Blood Substitutes

1994 • 23 citations

Redox Reactivity of Modified Hemoglobins with Hydrogen Peroxide and Nitric Oxide: Toxicological Implications

1994 • 23 citations

[21] Nitric oxide and metal-catalyzed reactions

1996 • 19 citations