SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

1998 • 1,090 citations

Type I iodothyronine deiodinase is a selenocysteine-containing enzyme

1991 • 884 citations

A Perfect Message

1999 • 807 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region

1991 • 642 citations

Evidence for specific selenium target tissues and new biologically important selenoproteins

1988 • 466 citations

Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons.

1993 • 429 citations

Binary specification of nonsense codons by splicing and cytoplasmic translation

1998 • 396 citations

A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs

2000 • 381 citations

Decoding apparatus for eukaryotic selenocysteine insertion

2000 • 304 citations

Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium.

1995 • 296 citations

Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation

2000 • 288 citations

Selenium Deficiency Reduces the Abundance of mRNA for Se-Dependent Glutathione Peroxidase 1 by a UGA-Dependent Mechanism Likely To Be Nonsense Codon-Mediated Decay of Cytoplasmic mRNA

1998 • 221 citations

Type 2 iodothyronine deiodinase is highly expressed in human thyroid.

1996 • 200 citations

Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase

1991 • 200 citations

Cloning and Functional Characterization of Human Selenophosphate Synthetase, an Essential Component of Selenoprotein Synthesis

1995 • 187 citations

Coding from a distance: dissection of the mRNA determinants required for the incorporation of selenocysteine into protein.

1992 • 185 citations

Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA.

1993 • 182 citations

Escherichia coli genes whose products are involved in selenium metabolism

1988 • 182 citations

Ancient Ciphers: Translation in Archaea

1997 • 159 citations

Differential regulation of rat liver selenoprotein mRNAs in selenium deficiency

1992 • 156 citations

Purification, Redox Sensitivity, and RNA Binding Properties of SECIS-binding Protein 2, a Protein Involved in Selenoprotein Biosynthesis

1999 • 152 citations

Dietary selenium affects methylation of the wobble nucleoside in the anticodon of selenocysteine tRNA([Ser]Sec)

1993 • 145 citations

Effect of selenium status on mRNA levels for glutathione peroxidase in rat liver

1988 • 145 citations

Domain Structure of the Prokaryotic Selenocysteine-specific Elongation Factor SelB

1996 • 114 citations

Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation

1992 • 113 citations

Dietary Selenium Stabilizes Glutathione Peroxidase mRNA in Rat Liver

1992 • 110 citations

Selenocysteine insertion or termination: factors affecting UGA codon fate and complementary anticodon:codon mutations

1994 • 109 citations

Regulation of Human Thioredoxin Reductase Expression and Activity by 3′-Untranslated Region Selenocysteine Insertion Sequence and mRNA Instability Elements

1999 • 108 citations

Selenocysteine tRNA^[Ser]Sec Gene Is Ubiquitous within the Animal Kingdom

1990 • 107 citations

Identification and characterisation of the selenocysteine-specific translation factor SelB from the archaeon Methanococcus jannaschii 1 1Edited by J. Karn

2000 • 104 citations

Repression mediates cell-type-specific expression of the rat growth hormone gene.

1986 • 99 citations

Analysis of Eukaryotic mRNA Structures Directing Cotranslational Incorporation of Selenocysteine

1996 • 91 citations

Selenocysteine incorporation in eukaryotes: insights into mechanism and efficiency from sequence, structure, and spacing proximity studies of the type 1 deiodinase SECIS element.

1996 • 85 citations

An RNA-Binding Protein Recognizes a Mammalian Selenocysteine Insertion Sequence Element Required for Cotranslational Incorporation of Selenocysteine

1997 • 82 citations

Cis-acting elements are required for selenium regulation of glutathione peroxidase-1 mRNA levels

1998 • 77 citations

Selenocysteine tRNA[Ser]Sec gene is ubiquitous within the animal kingdom.

1990 • 72 citations

Replenishment of selenium deficient rats with selenium results in redistribution of the selenocysteine tRNA population in a tissue specific manner

1997 • 59 citations

Role of stoichiometry between mRNA, translation factor SeIB and selenocysteyl‐tRNA in selenoprotein synthesis

1996 • 52 citations

Functionality of mutations at conserved nucleotides in eukaryotic SECIS elements is determined by the identity of a single nonconserved nucleotide.

1998 • 51 citations

Selenium and iodine deficiencies: effects on brain and brown adipose tissue selenoenzyme activity and expression

1997 • 50 citations