The comorbidity of bipolar and anxiety disorders: prevalence, psychobiology, and treatment issues

Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States

1994 • 12,456 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

Psychiatric disorders in America: the epidemiologic catchment area study

1991 • 2,589 citations

Manic-Depressive Insanity and Paranoia.

1921 • 1,607 citations

Manic-depressive illness

1991 • 1,538 citations

Manic Depressive Insanity and Paranoia

1921 • 1,183 citations

A Double-Blind Placebo-Controlled Study of Lamotrigine Monotherapy in Outpatients With Bipolar I Depression

1999 • 1,056 citations

Efficacy of Divalproex vs Lithium and Placebo in the Treatment of Mania

1994 • 872 citations

The emerging epidemiology of hypomania and bipolar II disorder

1998 • 767 citations

Manic Depressive Illness.

1970 • 720 citations

Axis I Psychiatric Comorbidity and Its Relationship to Historical Illness Variables in 288 Patients With Bipolar Disorder

2001 • 708 citations

Trauma and posttraumatic stress disorder in severe mental illness.

1998 • 627 citations

The epidemiology of DSM-III-R bipolar I disorder in a general population survey

1997 • 615 citations

Noradrenergic Function in Panic Anxiety

1984 • 602 citations

Guidelines for the Rational Use of Benzodiazepines

1994 • 581 citations

Olanzapine Versus Placebo in the Treatment of Acute Mania

1999 • 580 citations

Haloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder

1994 • 569 citations

Trauma and posttraumatic stress disorder in severe mental illness.

1998 • 566 citations

Efficacy of Olanzapine in Acute Bipolar Mania<subtitle>A Double-blind, Placebo-Controlled Study</subtitle>

2000 • 557 citations

Consensus statement on panic disorder from the International Consensus Group on Depression and Anxiety.

1998 • 473 citations

A Placebo-Controlled Study of Lamotrigine and Gabapentin Monotherapy in Refractory Mood Disorders

2000 • 455 citations

Valproatereatment of Acute Mania

1991 • 441 citations

Treatment of Social Phobia With Gabapentin

1999 • 396 citations

Decreased Brain GABAA-Benzodiazepine Receptor Binding in Panic Disorder

1998 • 355 citations

Fluoxetine in post-traumatic stress disorder

1999 • 353 citations

Gabapentin in bipolar disorder: a placebo‐controlled trial of adjunctive therapy1

2000 • 318 citations

Sustained urinary norepinephrine and epinephrine elevation in post-traumatic stress disorder

1987 • 310 citations

Urinary Catecholamine Excretion and Severity of PTSD Symptoms in Vietnam Combat Veterans

1992 • 309 citations

A Factor Analysis of the Signs and Symptoms of Mania

1998 • 294 citations

The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy

1996 • 286 citations

ACUTE CARBON TETRACHLORIDE POISONING IN 19 PATIENTS: IMPLICATIONS FOR DIAGNOSIS AND TREATMENT

1985 • 278 citations

Treatment of Social Phobia With Clonazepam and Placebo

1993 • 275 citations

Spectrum of efficacy of valproate in 55 patients with rapid-cycling bipolar disorder

1990 • 271 citations

Clozapine for treatment-refractory mania

1996 • 269 citations

Obsessive–Compulsive Disorder

1996 • 268 citations

Cyclothymic Temperamental Disorders

1979 • 264 citations

GABA levels in CSF of patients with psychiatric disorders

1980 • 263 citations

The prevalence of major depressive and bipolar disorders in Hungary

1998 • 245 citations

Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial.

1998 • 244 citations

The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed byd-serine

1996 • 234 citations

Rapidly Cycling Affective Disorder

1992 • 232 citations

Anxiety as a Correlate of Response to the Acute Treatment of Bipolar I Disorder

2000 • 231 citations

Prevalence of anxiety disorders comorbidity in bipolar depression, unipolar depression and dysthymia

1997 • 230 citations

Double-blind, controlled trial of inositol treatment of depression

1995 • 229 citations

Comorbidity of panic disorder in bipolar illness: evidence from the Epidemiologic Catchment Area Survey

1995 • 228 citations

Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: A study and replication

1996 • 227 citations

Comorbidity for obsessive-compulsive disorder in bipolar and unipolar disorders

1995 • 219 citations

Efficacy of divalproex vs lithium and placebo in the treatment of mania. The Depakote Mania Study Group

1994 • 217 citations

Lithium Carbonate and Imipramine in the Prophylaxis of Unipolar and Bipolar II Illness

1982 • 213 citations

The clinical impact of bipolar and unipolar affective comorbidity on obsessive–compulsive disorder

1997 • 210 citations

Double-Blind Comparison of Addition of a Second Mood Stabilizer Versus an Antidepressant to an Initial Mood Stabilizer for Treatment of Patients With Bipolar Depression

2000 • 209 citations

Inositol treatment of obsessive-compulsive disorder

1996 • 209 citations

Comparison of Alprazolam, Imipramine, and Placebo in the Treatment of Depression

1983 • 197 citations

Posttraumatic stress disorder and comorbidity: recognizing the many faces of PTSD.

1997 • 197 citations

The Pharmacologic Basis of Antiepileptic Drug Action

1999 • 188 citations

Social phobia: a pharmacologic treatment overview.

1995 • 185 citations

Differences and similarities in mixed and pure mania

1995 • 183 citations

Signs and symptoms of mania in pure and mixed episodes

1998 • 181 citations

Anxious and non-anxious bipolar disorder

1993 • 180 citations

Suicidality, panic disorder and psychosis in bipolar depression, depressive-mania and pure-mania

1997 • 178 citations

Somatic Treatment of Catatonia

1995 • 175 citations

Behavioral indications for serotonin receptor hypersensitivity in panic disorder

1988 • 174 citations

Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder

1995 • 171 citations

Olanzapine compared to lithium in mania: a double-blind randomized controlled trial

1999 • 170 citations

Risperidone in the treatment of affective illness and obsessive-compulsive disorder.

1995 • 165 citations

Pharmacologic agents for the treatment of acute bipolar mania

2000 • 165 citations

Dysphoric Mania

1989 • 164 citations

A controlled trial of lithium augmentation in fluvoxamine-refractory obsessive-compulsive disorder: lack of efficacy.

1991 • 162 citations

Valproate in combat-related posttraumatic stress disorder

1991 • 157 citations

Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder

1997 • 155 citations

How Psychiatrists Can Build New Therapies for Impotence

1998 • 153 citations

Emergence of obsessive compulsive symptoms during treatment with clozapine.

1992 • 153 citations

The effect of Citalopram in panic disorder

1997 • 152 citations

Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder

1994 • 148 citations

Serotonergic function after (±)3,4-methylene-dioxymethamphetarnine (‘Ecstasy’) in humans

1998 • 146 citations

Prophylactic Lithium Carbonate With and Without Imipramine for Bipolar 1 Patients

1981 • 146 citations

Depressive comorbidity of panic, social phobic, and obsessive–compulsive disorders re-examined: is there a bipolar ii connection?

1999 • 144 citations

Bipolar disorder and panic disorder in families: an analysis of chromosome 18 data.

1998 • 143 citations

Comorbidity of obsessive compulsive disorder in bipolar disorder

1995 • 143 citations

Antidepressant-associated hypomania in outpatient depression: A 203-case study in private practice

1997 • 138 citations

A Double-Blind, Controlled Comparison of the Novel Antipsychotic Olanzapine versus Haloperidol or Placebo on Anxious and Depressive Symptoms Accompanying Schizophrenia

1998 • 136 citations

A 1 year double-blind placebo-controlled fixed dose study of sertraline in the treatment of obsessive-compulsive disorder

1995 • 135 citations

Risperidone addition in fluvoxamine-refractory obsessive-compulsive disorder: three cases.

1995 • 131 citations

A Controlled Trial of Lithium Augmentation in Fluvoxamine-Refractory Obsessive-Compulsive Disorder

1991 • 130 citations

Neurobiology of lithium: an update.

1998 • 130 citations

THE SWITCH PROCESS FROM DEPRESSION TO MANIA: RELATIONSHIP TO DRUGS WHICH ALTER BRAIN AMINES

1970 • 130 citations

Is clozapine a mood stabilizer?

1995 • 130 citations

Long-Term use of Benzodiazepines: Tolerance, Dependence and Clinical Problems in Anxiety and Mood Disorders

2007 • 129 citations

Effects of Carbamazepine on Plasma Haloperidol Levels

1985 • 125 citations

Affective comorbidity in panic disorder: Is there a bipolar connection?

1993 • 119 citations

Panic disorder with familial bipolar disorder

1997 • 118 citations

Cerebrospinal fluid gamma-aminobutyric acid and homovanillic acid in depressive disorders.

1982 • 117 citations

A Controlled Comparison of Adjuvant Lithium Carbonate or Thyroid Hormone in Clomipramine-Treated Patients with Obsessive-Compulsive Disorder

1991 • 116 citations

Development of transient obsessive-compulsive symptoms during treatment with clozapine

1992 • 115 citations

Inpatient Clinical Trial of Lorazepam for the Management of Manic Agitation

1985 • 112 citations

Role of serotonin in obsessive-compulsive disorder

1998 • 108 citations

Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder.

1978 • 108 citations

Panic disorder: treatment with valproate.

1994 • 107 citations

Investigation of dopamine system genes in obsessive-compulsive disorder

1998 • 105 citations

Clozapine in severe mood disorders.

1995 • 104 citations

TREATMENT-RESISTANT BIPOLAR DEPRESSION

1996 • 102 citations

Efficacy of Divalproex Sodium in Patients with Panic Disorder and Mood Instability Who Have Not Responded to Conventional Therapy

1998 • 100 citations

Valproic Acid and Panic Disorder

1990 • 98 citations

Olanzapine in treatment-resistant bipolar disorder

1998 • 98 citations

Adjunctive treatment of manic agitation with lorazepam versus haloperidol: a double-blind study.

1992 • 98 citations

Lamotrigine toxicity secondary to sertraline

1998 • 96 citations

ANXIOUS–BIPOLAR COMORBIDITY

1999 • 96 citations

Lithium and tryptophan augmentation in clomipramine-resistant obsessive- compulsive disorder

1984 • 96 citations

Valproate treatment of panic disorder and lactate-induced panic attacks

1993 • 94 citations

Lack of efficacy of carbamazepine in the treatment of panic disorder

1988 • 94 citations

Role of gamma-aminobutyric acid in antipanic drug efficacy

1989 • 93 citations

Olanzapine and the new generation of antipsychotic agents: patterns of use.

1997 • 92 citations

A pilot trial of adjunctive gabapentin in the treatment of bipolar disorder.

1997 • 90 citations

Carbamazepine but not Valproate Induces Bupropion Metabolism

1995 • 89 citations

Acute Treatment of Bipolar Depression with Gabapentin

1997 • 85 citations

The role of serotonin in panic, anxiety and depression

1998 • 84 citations

Social anxiety, hypomania and the bipolar spectrum: data, theory and clinical issues

1998 • 83 citations

Lithium Carbonate Treatment of Mania

1987 • 83 citations

Cerebrospinal Fluid MHPG

1973 • 81 citations

Biological Therapies for Posttraumatic Stress Disorder: An Overview

1997 • 80 citations

The Use of Quetiapine for Treatment-Resistant Bipolar Disorder: A Case Series

1999 • 78 citations

Clinical Improvement With Fluoxetine Therapy and Noradrenergic Function in Patients With Panic Disorder

1997 • 77 citations

Valproate in combat-related posttraumatic stress disorder.

1991 • 74 citations

A Pilot Trial of Adjunctive Gabapentin in the Treatment of Bipolar Disorder

1997 • 70 citations

CSF GABA in depressed patients and normal controls

1991 • 67 citations

Bupropion in the treatment of bipolar disorders: the same old story?

1992 • 66 citations

Gabapentin in the acute treatment of refractory bipolar disorder

1999 • 66 citations

Outcome and Comorbidity in First- Compared with Multiple-Episode Mania

1995 • 66 citations

Low Dose Lithium Carbonate in the Treatment of Post Traumatic Stress Disorder: Brief Communication

1985 • 64 citations

Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients

1985 • 64 citations

Dopaminergic function in panic disorder: Comparison with major and minor depression

1992 • 63 citations

The Co-Occurrence of Mania with Medical and other Psychiatric Disorders

1994 • 63 citations

Plasma GABA in mood disorders.

1990 • 63 citations

Use of clonazepam for bipolar affective disorder.

1990 • 60 citations

Inositol monophosphatase, the putative therapeutic target for lithium

1996 • 58 citations

Use of Clomipramine in Treatment of Obsessive-Compulsive Symptomatology

1984 • 56 citations

CSF GABA in euthymic manie-depressive patients and controls

1986 • 55 citations

Principles of Clinically Important Drug Interactions with Carbamazepine. Part I

1991 • 55 citations

Treatment of obsessive-compulsive disorder with lithium carbonate

1983 • 54 citations

Plasma GABA predicts acute response to divalproex in mania

1996 • 53 citations

Lithium for irritability in Post-Traumatic stress disorder

1995 • 53 citations

Manic-depressive insanity.

1925 • 53 citations

Treatment of Acute Bipolar Depression: A Review of the Literature

1995 • 50 citations

Urinary catecholamines and plasma hormones predict mood state in rapid cycling bipolar affective disorder

1995 • 48 citations

Clonazepam treatment of five lithium-refractory patients with bipolar disorder

1989 • 48 citations

Obsessive-compulsive symptoms in schizophrenia: a comparison of olanzapine and placebo.

1996 • 46 citations

Effective short-term treatment of generalized anxiety disorder with trifluoperazine.

1986 • 46 citations

Three case reports of acute paroxysmal excitement associated with alprazolam treatment

1985 • 44 citations

d-fenfluramine-induced prolactin responses in mania: evidence for serotonergic subsensitivity

1996 • 43 citations

Lithium for irritability in post‐traumatic stress disorder

1995 • 42 citations

Mood-related obsessive-compulsive symptoms in a patient with bipolar affective disorder.

1988 • 42 citations

Inositol treatment in psychiatry.

1995 • 39 citations

Adjunctive Use of Olanzapine in Mood Disorders: Five Case Reports

1997 • 39 citations

Adjunctive Clonazepam for Maintenance Treatment of Bipolar Affective Disorder

1990 • 38 citations

Adjunctive use of olanzapine in mood disorders: five case reports.

1997 • 38 citations

Mood Swings in Patients with Panic Disorder

1994 • 37 citations

Comparison of alprazolam, imipramine, and placebo in the treatment of depression

1983 • 37 citations

Carbamazepine in obsessive-compulsive disorder

1987 • 36 citations

Plasma GABA in Children and Adolescents with Mood, Behavior, and Comorbid Mood and Behavior Disorders: A Preliminary Study

1997 • 34 citations

Lithium prophylaxis of tricyclic-antidepressant-induced mania in bipolar patients

1982 • 33 citations

Behavioral treatment in two cases of obsessive-compulsive disorder with concomitant bipolar affective disorder

1985 • 33 citations

A Review of 19 Double-Blind Placebo-Controlled Studies in Social Anxiety Disorder (Social Phobia)

2000 • 32 citations

Combined lithium-tricyclic treatment of obsessive-compulsive disorder

1988 • 31 citations

Response of obsessive compulsive disorder to carbamazepine in two patients with comorbid epilepsy.

1997 • 28 citations

Antidepressant-induced rapid cycling: six case reports.

1993 • 28 citations

Alprazolam-Induced Manic Reaction

1984 • 28 citations

Alprazolam-induced manic episode in two patients with panic disorder

1986 • 27 citations

An Inverse Relationship Between Mania and Obsessive-Compulsive Disorder

1986 • 27 citations

Divalproex sodium's antipanic effect in panic disorder: A placebo-controlled study

1990 • 27 citations

Carbamazepine-induced reduction of plasma alprazolam concentrations: a clinical case report.

1988 • 26 citations

Risperidone treatment of refractory acute mania.

1995 • 25 citations

Response of Obsessive Compulsive Disorder to Carbamazepine in TWo Patients with Comorbid Epilepsy

1997 • 24 citations

Review of current treatment in panicc disorder

1998 • 24 citations

Mixed bipolar disorder responsive to lithium and clonazepam.

1986 • 23 citations

Somatic manifestations of normal and pathological anxiety.

1993 • 23 citations

Lithium augmentation of clomipramine.

1988 • 23 citations

Plasma levels of gamma-aminobutyric acid and panic disorder

1996 • 21 citations

Buspirone in the Treatment of Posttraumatic Stress Disorder

1994 • 21 citations

Parkinsonian symptoms with lithium, lithium-neuroleptic, and lithium-antidepressant treatment

1983 • 21 citations

Cerebrospinal fluid gamma-aminobutyric acid in patients with panic disorder

1995 • 21 citations

Plasma 3‐methoxy‐4‐hydroxyphenylglycol in manic patients: relationships with clinical variables

1990 • 20 citations

Innovative uses of benzodiazepines in psychiatry.

1993 • 20 citations

Antidepressant-Induced Rapid Cycling

1993 • 20 citations

Bupropion and Secondary Mania: Is There a Relationship?

1993 • 19 citations

A case of alprazolam, but not lorazepam, inducing manic symptoms.

1987 • 18 citations

Valproate as an Alternative in Post-Traumatic Stress Disorder: A Case Report

1995 • 18 citations

New uses for antidepressants: social phobia.

1997 • 17 citations

Benzodiazepines for the treatment of panic disorder and generalized anxiety disorder: clinical issues and future directions.

1993 • 16 citations

The effects of valproate in brain monoamines of juvenile rats after stress

1993 • 15 citations

Alprazolam in Bipolar‐I Depressions

1984 • 14 citations

Li+ stimulates ATP-regulated dopamine uptake in PC12 cells

1995 • 14 citations

Post traumatic stress disorder: an eclectic approach.

1990 • 13 citations

A comparison of thioridazine and diazepam in non-psychotic anxiety-depression: a pilot study.

1972 • 12 citations

Peripheral action of serotonin as a model of depression

1986 • 12 citations

Thiothixene and Thioridazine in Anxiety

1974 • 12 citations

Evoked Potentials in Clinical Medicine (Second Edition)

1990 • 11 citations

Clonazepam and Lithium—a Toxic Combination in the Treatment of Mania?

1989 • 11 citations

A double-blind comparison of thioridazine (Mellaril) versus diazepam (valium) in patients with chronic mixed anxiety and depressive symptoms.

1973 • 8 citations

[Valpromide-amitriptyline interaction. Increase in the bioavailability of amitriptyline and nortriptyline caused by valpromide].

1990 • 8 citations

Valproate Treatment of Comorbid Panic Disorder and Affective Disorders in Two Alcoholic Patients

1994 • 5 citations

Probable Nefazodone-Induced Mania in a Patient with Unreported Bipolar Disorder

1996 • 5 citations