Calpain activity in adult and aged human brain regions

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Isolated removal of hypothalamic or other brain nuclei of the rat

1973 • 1,421 citations

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease.

1991 • 249 citations

Use of fluorescamine in the chromatographic analysis of peptides from proteins

1974 • 199 citations

The ultrastructural localization of calcium‐activated protease “calpain” in rat brain

1988 • 112 citations

Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease

1991 • 108 citations

Proteolytic processing of beta-amyloid precursor by calpain I

1990 • 105 citations

The Lysosomal System in Neurons

1992 • 102 citations

Age-related increase in a cathepsin D-like protease that degrades brain microtubule-associated proteins

1987 • 80 citations

[48] Purification and characterization of an inhibitor protein of cyclic AMP-dependent protein kinases

1974 • 70 citations

Calcium‐Activated Neutral Proteinases as Regulators of Cellular Function Implications for Alzheimer's Disease Pathogenesis^a

1989 • 68 citations

Calpain and calpastatin in normal and Alzheimer-degenerated human brain tissue

1990 • 64 citations

The Distribution of Cathepsin D Activity in Adult and Aging Human Brain Regions

1992 • 63 citations

Increase in cathepsin D activity in rat brain in aging

1989 • 58 citations

Regional distribution of soluble calcium activated proteinase activity in neonatal and adult rat brain

1985 • 57 citations

A simple one-step procedure for the separation of calpain I, calpain II and calpastatin

1985 • 48 citations

Brain Microdissection Techniques

1984 • 46 citations

Localization of calpain immunoreactivity in senile plaques and in neurones undergoing neurofibrillary degeneration in Alzheimer's disease

1991 • 45 citations

Accumulation of inactive cathepsin D in old rats

1984 • 42 citations

Tissue distribution of calcium-activated neutral proteinases in rat

1988 • 41 citations

Distribution of calcium activated neutral proteinase (mM CANP) in myelin and cytosolic fractions in bovine brain white matter

1987 • 36 citations

Age-dependent change in activities of lysosomal enzymes in rat brain

1989 • 35 citations

Myelin‐Associated Calpain II

1988 • 35 citations

Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease

1991 • 32 citations

Age-related changes in calpain II and calpastatin in rat lens

1989 • 29 citations

Developmental changes of calpain and calpastatin in rabbit brain

1989 • 29 citations

Calpain II activity and calpastatin content in brain regions of 3- and 24-month-old rats

1990 • 28 citations

The regional and subcellular distribution of calcium activated neutral proteinase (CANP) in the bovine central nervous system

1989 • 26 citations

Subcellular compartmentalization of calcium‐dependent and calcium‐independent neutral proteases in brain

1987 • 26 citations

Calcium‐activated neutral proteinase (CANP; calpain) activity in Schwann cells: Immunofluorescence localization and compartmentation of μ‐ and mCANP

1991 • 23 citations

Immunoassay and Activity of Calcium‐Activated Neutral Proteinase (mCANP): Distribution in Soluble and Membrane‐Associated Fractions in Human and Mouse Brain

1992 • 23 citations

Purification of a novel type of calcium-activated neutral protease from rat brain. Possible involvement in production of the neuropeptide kyotorphin from calpastatin fragments.

1990 • 21 citations

Calcium-activated neutral proteinase (calpain) in rat brain during development: compartmentation and role in myelination

1993 • 20 citations

Regional distribution of brain calpastatin and of calpain II. Activity with casein and with endogenous brain protein substrates

1989 • 14 citations

Lysosomal proteinases as putative diagnostic tools in human neuropathology: Alzheimer disease (AD) and schizophrenia.

1992 • 14 citations

Comparison of Ca2+-activated proteinase enzyme and endogeneous inhibitor activity in brain tissue from normal and Alzheimer's disease cases

1991 • 13 citations

Compartmentation and glycoprotein substrates of calpain in the developing rat brain

1991 • 12 citations

Distribution of cathepsin D immunoreactivity in the central nervous system of rat and selected brain regions of man

1985 • 12 citations

Distributional and Developmental Variations of Multiple Forms of Calpastatin in Mouse Brain

1990 • 3 citations