Synthesis, Opiate Receptor Binding and Analgesic Activity of Enkephalin Analogues

Automatic Recording Apparatus for Use in Chromatography of Amino Acids

1958 • 9,612 citations

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen

1970 • 1,555 citations

Opiates and endogenous opioid peptides

1977 • 1,282 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1973 • 650 citations

Analgesia induced in vivo by central administration of enkephalin in rat

1976 • 524 citations

Opioid Peptides Endorphins in Pituitary and Brain

1976 • 518 citations

Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates

1976 • 516 citations

Properties of Opiate-Receptor Binding in Rat Brain

1973 • 437 citations

Reinvestigation of the mixed carbonic anhydride method of peptide synthesis

1967 • 407 citations

A synthetic enkephalin analogue with prolonged parenteral and oral analgesic activity

1977 • 395 citations

An endogenous morphine-like factor in mammalian brain

1975 • 393 citations

Verbesserte Synthese von tert.‐Butyloxycarbonyl‐aminosäuren durch pH‐Stat‐Reaktion

1967 • 383 citations

Search for an Endogenous Ligand for the Opiate Receptor

1975 • 315 citations

Some thoughts on the significance of enkephalin, the endogenous ligand

1975 • 270 citations

Enkephalin pentapeptides — A review of current evidence for a physiological role in vertebrate neurotransmission

1977 • 269 citations

Evidence for analgesic activity of enkephalin in the mouse

1976 • 252 citations

Current Developments in Psychopharmacology

1978 • 242 citations

Purification and properties of enkephalin — The possible endogenous ligand for the morphine receptor

1975 • 240 citations

Das 4,4′-tetramethyldiamino-diphenylmethan reagens (TDM)

1976 • 204 citations

Studies on Arginine Peptides. I. Intermediates in the Synthesis of N-Terminal and C-Terminal Arginine Peptides^*

1957 • 193 citations

Opiate receptor in normal and drug altered brain function*

1975 • 184 citations

Phylogenetic distribution of opiate receptor binding

1974 • 175 citations

Enkephalin catabolism in vitro and in vivo

1977 • 168 citations

Effects of the synthetic enkephalin analogue FK 33-824 in man

1978 • 160 citations

In vitro release of Leu- and Met-enkephalin from the corpus striatum

1978 • 158 citations

A superactive antinociceptive pentapeptide, (D‐Met²,Pro⁵)‐enkephalinamide

1977 • 157 citations

Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brain

1976 • 152 citations

N-Methylamino acids in peptide synthesis. V. The synthesis of N-tert-butyloxycarbonyl, N-methylamino acids by N-methylation

1977 • 142 citations

Release of enkephalin from rat globus pallidus in vitro

1978 • 132 citations

Synthesis and opioid activities of stereoisomers and other D-amino acid analogs of methionine-enkephalin

1976 • 128 citations

Derivate von L‐Methionin‐sulfoxyd und ihre Verwendung für Peptidsynthesen

1961 • 117 citations

Extremely rapid degradation of [3H] methionine-enkephalin by various rat tissues and

1977 • 115 citations

Structural requirements for opioid activity of analogues of the enkephalins

1977 • 108 citations

The metabolic stability of the enkephalins

1977 • 90 citations

Studies on Optically Active Amino Acids. V. Synthesis of Optically Active α-Aminoalcohols by the Reduction of α-Amino Acid Esters with Sodium Borohydride

1965 • 82 citations

THE OXIDATION OF THE SULFUR OF HOMOCYSTINE, METHIONINE, AND S-METHYLCYSTEINE IN THE ANIMAL BODY

1934 • 72 citations

Opiate receptor affinity of peptides related to Leu-enkephalin

1976 • 72 citations

Chloroauric acid as oxidant. Stereospecific oxidation of methionine to methionine sulfoxide

1976 • 66 citations

Enkephalin analogues eliciting analgesia after intravenous injection

1977 • 57 citations

Boron Tris(trifluoroacetate) for Removal of Protecting Groups in Peptide Chemistry

1973 • 51 citations

The enkephalins and opiates: structure-activity relations

1977 • 42 citations

N-Methylamino acids in peptide synthesis. VII. Studies on the enantiomeric purity of N-methylamino acids prepared by various procedures

1977 • 32 citations

Human endorphin: Comparison with porcine endorphin, enkephalin and normorphine

1976 • 18 citations

Recombinant DNA research: a debate on the benefits and risks.

1977 • 9 citations