The toxins of Bacteroides fragilis

A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.

1995 • 1,239 citations

Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution

1997 • 1,123 citations

Human Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians

1974 • 1,066 citations

Glucosylation of Rho proteins by Clostridium difficile toxin B

1995 • 1,025 citations

E-Cadherin Is the Receptor for Internalin, a Surface Protein Required for Entry of L. monocytogenes into Epithelial Cells

1996 • 853 citations

The Comprehensive Sourcebook of Bacterial Protein Toxins

2015 • 601 citations

Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions.

1991 • 570 citations

Human Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians

1974 • 537 citations

The Enterotoxin from Clostridium difficile (ToxA) Monoglucosylates the Rho Proteins

1995 • 478 citations

Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion

1996 • 451 citations

Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin

1998 • 358 citations

Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.

1995 • 337 citations

Accessory cholera enterotoxin (Ace), the third toxin of a Vibrio cholerae virulence cassette.

1993 • 275 citations

Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model.

1997 • 265 citations

Antimicrobial Resistance and Clinical Outcome of Bacteroides Bacteremia: Findings of a Multicenter Prospective Observational Trial

2000 • 209 citations

Bacteroides fragilis Subspecies in Clinical Isolates

1977 • 188 citations

Bacteroides fragilis Enterotoxin Gene Sequences in Patients with Inflammatory Bowel Disease

2000 • 185 citations

The enterotoxin of Bacteroides fragilis is a metalloprotease

1995 • 174 citations

Isolation of enterotoxigenic Bacteroides fragilis from humans with diarrhea

1987 • 157 citations

Bacteroides fragilis: a possible cause of acute diarrheal disease in newborn lambs

1984 • 155 citations

Pathogenicity islands and the evolution of bacterial pathogens.

1996 • 136 citations

Isolation of enterotoxigenic Bacteroides fragilis from Bangladeshi children with diarrhea: a controlled study

1994 • 119 citations

The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells

1997 • 118 citations

Human colonic epithelial cells, HT29/C1, treated with crude Bacteroides fragilis enterotoxin dramatically alter their morphology

1992 • 115 citations

The elastase propeptide functions as an intramolecular chaperone required for elastase activity and secretion in Pseudomonas aeruginosa

1995 • 113 citations

Properties of ion channels formed by Staphylococcus aureus δ-toxin

1988 • 105 citations

Bacteroides fragilis enterotoxin modulates epithelial permeability and bacterial internalization by HT-29 enterocytes

1996 • 101 citations

Enterotoxigenic Bacteroides fragilis: epidemiologic studies of its role as a human diarrhoeal pathogen.

1992 • 101 citations

Attributable Mortality of Bacteremia Associated with the Bacteroides fragilis Group

1995 • 98 citations

Intramolecular Chaperone: The Role of the Pro-Peptide in Protein Folding

1991 • 96 citations

Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo

1995 • 95 citations

Bacteroides fragilisenterotoxin induces the expression of IL-8 and transforming growth factor-beta (TGF-β) by human colonic epithelial cells

2000 • 95 citations

Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene

1997 • 88 citations

Molecular Evolution of the Pathogenicity Island of Enterotoxigenic Bacteroides fragilis Strains

1999 • 86 citations

Association of Bacteroides fragilis with Childhood Diarrhea

1995 • 79 citations

Enterotoxigenic Bacteroides fragilis

1995 • 79 citations

Prevalence of Enterotoxigenic Bacteroides fragilis in Adult Patients with Diarrhea and Healthy Controls

1999 • 77 citations

Bacteroides fragilis toxin exhibits polar activity on monolayers of human intestinal epithelial cells (T84 cells) in vitro

1997 • 75 citations

Advances in research on cholera and related diarrheas

1990 • 69 citations

Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis

1996 • 69 citations

Association of Enterotoxigenic Bacteroides fragilis with Diarrheal Disease in Calves

1985 • 68 citations

Molecular Characterization of the Fragilysin Pathogenicity Islet of Enterotoxigenic Bacteroides fragilis

1998 • 62 citations

Identification of a Third Metalloprotease Toxin Gene in Extraintestinal Isolates of Bacteroides fragilis

1999 • 61 citations

Diarrheal disease caused by enterotoxigenic Bacteroides fragilis in infant rabbits

1989 • 58 citations

Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis

2006 • 58 citations

Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis

1997 • 57 citations

Detection of Toxin Production by Bacteroides fragilis: Assay Development and Screening of Extraintestinal Clinical Isolates

1996 • 55 citations

Zonula Occludens Toxin Is a Powerful Mucosal Adjuvant for Intranasally Delivered Antigens

1999 • 54 citations

Detection of Enterotoxigenic Bacteroides fragilis and Its Toxin in Stool Samples from Adults and Children in Italy

1997 • 54 citations

A new subtype of the metalloprotease toxin gene and the incidence of the threebftsubtypes amongBacteroides fragilisisolates in Japan

2000 • 51 citations

Association of Enterotoxigenic Bacteroides fragilis with Bacteremia

1996 • 51 citations

Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells

1996 • 50 citations

The structure ofEscherichia coliheat-stable enterotoxin b by nuclear magnetic resonance and circular dichroism

1995 • 46 citations

Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro

1999 • 42 citations

Bacteroides fragilis toxin rapidly intoxicates human intestinal epithelial cells (HT29/C1) in vitro

1996 • 38 citations

The Alleles of the bft Gene Are Distributed Differently among Enterotoxigenic Bacteroides fragilis Strains from Human Sources and Can Be Present in Double Copies

2000 • 37 citations

Prevalence of Enterotoxigenic Bacteroides fragilis in Children with Diarrhea in Japan

1999 • 32 citations

Bacteroides fragilis toxin rearranges the actin cytoskeleton of HT29/C1 cells without direct proteolysis of actin or decrease in F-actin content

1997 • 32 citations

Modulation of bft expression by the Bacteroides fragilis pathogenicity island and its flanking region

2002 • 31 citations

Ion channel formation by synthetic analogues of staphylococcal δ-toxin

1995 • 27 citations

Characterization of enterotoxigenic Bacteroides fragilis by a toxin-specific enzyme-linked immunosorbent assay

1994 • 23 citations

Fragilysin, the enterotoxin from Bacteroides fragilis, enhances the serum antibody response to antigen co-administered by the intranasal route

2000 • 21 citations

Prevalence and Antimicrobial Susceptibility of Enterotoxigenic Bacteroides fragilis in Children with Diarrhoea in Nicaragua

2000 • 19 citations

Production of antisera against the enterotoxin of Bacteroides fragilis and their use in a cytotoxicity neutralization assay of HT-29 cells

1994 • 17 citations

Medical and Environmental Aspects of Anaerobes

1992 • 17 citations

Molecular Modeling and Analysis of Fragilysin, theBacteroides fragilisToxin.

1997 • 16 citations