Is ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol

Nucleus accumbens shell and core dopamine: differential role in behavior and addiction

2002 • 957 citations

Acetaldehyde Increases Dopaminergic Neuronal Activity in the VTA

2003 • 163 citations

The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats

2002 • 149 citations

Cocaine-induced suppression of saccharin intake: A model of drug-induced devaluation of natural rewards.

2002 • 126 citations

Dopamine-Derived Salsolinol Derivatives as Endogenous Monoamine Oxidase Inhibitors: Occurrence, Metabolism and Function in Human Brains

2003 • 114 citations

Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians.

1999 • 114 citations

Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate

2003 • 104 citations

Conditioned stimulus preference after acetaldehyde but not ethanol injections

2001 • 81 citations

Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity

2002 • 74 citations

Acetaldehyde-induced Changes in the Monoamine and Amino Acid Extracellular Microdialysate Content of the Nucleus Accumbens

1997 • 66 citations

Ethanol-stimulated behaviour in mice is modulated by brain catalase activity and H 2 O 2 rate of production

2002 • 62 citations

Salsolinol Produces Reinforcing Effects in the Nucleus Accumbens Shell of Alcohol‐Preferring (P) Rats

2003 • 54 citations

Involvement of Acetaldehyde in Alcohol Addiction

2002 • 51 citations

Brain catalase activity is highly correlated with ethanol-induced locomotor activity in mice

2001 • 50 citations

Behavioral effects of intraventricular injections of low doses of ethanol, acetaldehyde, and acetate in rats: studies with low and high rate operant schedules

2003 • 47 citations

Locomotor stimulant effects of intraventricular injections of low doses of ethanol in rats: acute and repeated administration

2003 • 47 citations

In Vivo Study of Salsolinol Produced by a High Concentration of Acetaldehyde in the Striatum and Nucleus Accumbens of Free‐Moving Rats

2003 • 36 citations

Aversion to acetaldehyde

2002 • 30 citations

Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats

2003 • 26 citations

IN VIVO FORMATION OF SALSOLINOL INDUCED BY HIGH ACETALDEHYDE CONCENTRATION IN RAT STRIATUM EMPLOYING MICRODIALYSIS

2003 • 24 citations

The effect of cyanamide and 4-methylpyrazole on the ethanol-induced locomotor activity in mice

2002 • 22 citations

Effect of acetaldehyde on acute tolerance and ethanol consumption in drinker and nondrinker rats.

2002 • 21 citations

Relationship of Brain Ethanol Metabolism to the Hypnotic Effect of Ethanol. II: Studies in Selectively Bred Rats and Mice

2001 • 20 citations

Relationship of Brain Ethanol Metabolism to the Hypnotic Effect of Ethanol. I: Studies in Outbred Animals

2001 • 20 citations

Discriminative stimulus effects of ethanol with a conditioned taste aversion procedure: lack of acetaldehyde substitution

2003 • 19 citations

Role of Acetaldehyde in the Discriminative Stimulus Effects of Ethanol

2002 • 19 citations

Concurrent administration of diethyldithiocarbamate and 4-methylpyrazole enhances ethanol-induced locomotor activity: the role of brain ALDH

2002 • 18 citations

Does Acetaldehyde Mediate Ethanol Action in the Central Nervous System?

2001 • 18 citations

DIFFERENT BLOOD ACETALDEHYDE CONCENTRATION FOLLOWING ETHANOL ADMINISTRATION IN A NEWLY DEVELOPED HIGH ALCOHOL PREFERENCE AND LOW ALCOHOL PREFERENCE RAT MODEL SYSTEM

2002 • 17 citations

Role of Acetaldehyde in the Discriminative Stimulus Effects of Ethanol

2002 • 17 citations

Role of catalase in ethanol-induced conditioned taste aversion: a study with 3-amino-1,2,4-triazole

2003 • 17 citations