Cyclic Nucleotides in Lymphocyte Proliferation and Differentiation

Advances in Cyclic Nucleotide Research.

1980 • 1,465 citations

Control of proliferation in animal cells

1974 • 1,177 citations

POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS

1972 • 921 citations

THE RELATION OF ADENOSINE-3', 5'-PHOSPHATE AND PHOSPHORYLASE TO THE ACTIONS OF CATECHOLAMINES AND OTHER HORMONES

1960 • 852 citations

Role of Cyclic Nucleotides in Growth Control

1975 • 692 citations

Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.

1975 • 691 citations

Studies of Nuclear Acidic Proteins

1971 • 497 citations

Elevation of Guanosine 3′,5′-Cyclic Phosphate in Rat Heart after Perfusion with Acetylcholine

1970 • 455 citations

RNA synthesis and histone acetylation during the course of gene activation in lymphocytes.

1966 • 445 citations

Concanavalin A Derivatives with Altered Biological Activities

1973 • 412 citations

Histone Phosphorylation: Stimulation by Adenosine 3′,5′-Monophosphate

1968 • 402 citations

Human lymphocyte metabolism. Effects of cyclic and noncyclic nucleotides on stimulation by phytohemagglutinin

1971 • 393 citations

Guanosine 3′:5′-Cyclic Monophosphate: A Possible Intracellular Mediator of Mitogenic Influences in Lymphocytes

1972 • 381 citations

Activation of T and B Lymphocytes by Insoluble Phytomitogens

1972 • 318 citations

Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin).

1966 • 312 citations

Lymphocyte blast transformation

1970 • 293 citations

ISOLATION, BIOCHEMICAL CHARACTERISTICS, AND BIOLOGICAL ACTIVITY OF A CIRCULATING THYMIC HORMONE IN THE MOUSE AND IN THE HUMAN

1975 • 288 citations

Receptors and Recognition

1976 • 288 citations

PURIFICATION AND PROPERTIES OF BOVINE THYMOSIN*

1975 • 282 citations

The Importance of Calcium Ions for the Regulation of Guanosine 3′:5′-Cyclic Monophosphate Levels

1973 • 276 citations

The role of calcium ions in initiating transformation of lymphocytes

1974 • 271 citations

Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotides

1975 • 270 citations

DIFFERENTIATION OF T CELLS INDUCED BY PREPARATIONS FROM THYMUS AND BY NONTHYMIC AGENTS

1973 • 252 citations

Guanosine 3′:5′-Cyclic Monophosphate and the Action of Insulin and Acetylcholine

1973 • 232 citations

Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier

1975 • 229 citations

Insulin Receptors in Human Circulating Cells and Fibroblasts

1972 • 228 citations

Possible involvement of cyclic GMP in growth control of cultured mouse cells

1974 • 227 citations

Lymphocyte stimulation

1975 • 210 citations

THE LYMPHOID TISSUES AND IMMUNE RESPONSES OF NEONATALLY THYMECTOMIZED MICE BEARING THYMUS TISSUE IN MILLIPORE DIFFUSION CHAMBERS

1964 • 209 citations

THE ROLE OF ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE IN THE REGULATION OF MAMMALIAN CELL DIVISION

1973 • 209 citations

Mitogenic Properties of a Calcium Ionophore, A23187

1974 • 203 citations

Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha.

1975 • 196 citations

Early stimulation of potassium uptake in lymphocytes treated with PHA

1970 • 191 citations

Metal Cation Requirements for Phytohemagglutinin-Induced Transformation of Human Peripheral Blood Lymphocytes

1970 • 187 citations

Advances in cyclic nucleotide research

1980 • 184 citations

Antigen stimulation of prostaglandin synthesis and control of immune responses.

1976 • 184 citations

Release of Prostaglandin by Mitogen- and Antigen-Stimulated Leukocytes in Culture

1974 • 177 citations

Effects of levamisole and imidazole on lymphocyte proliferation and cyclic nucleotide levels

1975 • 177 citations

The early uptake of radioactive calcium by human lymphocytes treated with phytohaemagglutinin.

1971 • 176 citations

Cyclic AMP, Cell Growth, and the Immune Response

1974 • 176 citations

INDUCTION OF T LYMPHOCYTES FROM PRECURSOR CELLS IN VITRO BY A PRODUCT OF THE THYMUS

1973 • 163 citations

Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man.

1975 • 160 citations

Effect of Cyclic 3',5'-Adenosine Monophosphate and Theophylline on Lymphocyte Transformation

1970 • 157 citations

Effect of Phytohemagglutinin on Lymphocyte Membrane Transport

1971 • 155 citations

The influence of intracellular levels of cyclic nucleotides on cell proliferation and the induction of antibody synthesis.

1975 • 154 citations

Emergence of Insulin Receptors on Human Lymphocytes During In Vitro Transformation

1972 • 153 citations

Studies on the mechanism by which phytohemagglutinin rapidly stimulates phospholipid metabolism of human lymphocytes

1971 • 144 citations

Alteration of the Cytotoxic Action of Sensitized Lymphocytes by Cholinergic Agents and Activators of Adenylate Cyclase

1972 • 143 citations

Stimulation of DNA synthesis and mitotic activity of thymic lymphocytes by cyclic adenosine 3′5′-monophosphate

1969 • 132 citations

Differences in Cyclic AMP Changes after Stimulation by Prostaglandins and Isoproterenol in Lymphocyte Subpopulations

1975 • 131 citations

LYMPHOCYTE DIFFERENTIATION FROM PRECURSOR CELLS IN VITRO*

1975 • 127 citations

Protein Kinase Modulator from Lobster Tail Muscle

1973 • 127 citations

Activation of guanyl cyclase and intracellular cyclic GMP by fibroblast growth factor

1974 • 125 citations

Early Nuclear Events in the Induction of Lymphocyte Proliferation by Mitogens

1974 • 123 citations

MONONUCLEOTIDES OF THE CELL NUCLEUS

1957 • 122 citations

The Biological Activity of Thymic Hormones

1976 • 121 citations

Phospholipid metabolism of stimulated lymphocytes: Activation of ACYL-CoA: Lysolecithin acyltransferases in microsomal membranes

1973 • 121 citations

Insulin Action in Isolated Rat Thymocytes

1972 • 117 citations

Properties of Adenylate Cyclase of Lymphoid Cells

1971 • 114 citations

Modulation of lymphocyte mitogenesis.

1975 • 111 citations

Differential Phosphorylation and Turnover of Nuclear Acidic Proteins during the Cell Cycle of Synchronized HeLa Cells

1974 • 111 citations

Correlation between mitogenicity and stimulation of calcium uptake in human lymphocytes

1974 • 111 citations

Regulation of lymphocyte responses in vitro,

1973 • 110 citations

Water-Soluble Insulin Receptors from Human Lymphocytes

1972 • 108 citations

Proceedings of the fifth leukocyte culture conference

1972 • 105 citations

Estrogen-Related Increases in Uterine Guanosine 3′:5′-Cyclic Monophosphate Levels

1974 • 103 citations

Role of Cyclic Adenosine 3′,5′-Monophosphate in Lymphocyte Mitogenesis

1974 • 96 citations

HORMONE-LIKE ACTIVITY OF A THYMUS HUMORAL FACTOR ON THE INDUCTION OF IMMUNE COMPETENCE IN LYMPHOID CELLS

1974 • 94 citations

STUDIES ON SOME PHYSICOCHEMICAL PROPERTIES OF A THYMUS HUMORAL FACTOR CONFERRING IMMUNOCOMPETENCE ON LYMPHOID CELLS

1970 • 92 citations

Direct Action of Insulin on Plasma Membrane ATPase Activity in Human Lymphocytes

1972 • 90 citations

Characteristics of calcium accumulation by lymphocytes and alterations in the process induced by phytohemagglutinin

1973 • 86 citations

Phosphorylation of Lymphocyte Nuclear Acidic Proteins: Regulation by Cyclic Nucleotides

1975 • 80 citations

STUDIES ON THYMUS FUNCTION

1970 • 79 citations

Cyclic AMP and cyclic GMP concentrations in serum- and density-restricted fibroblast cultures.

1975 • 78 citations

ENHANCEMENT OF IN VIVO INCORPORATION OF LABELED PRECURSORS INTO DNA AND TOTAL PROTEIN OF MOUSE LYMPH NODES AFTER ADMINISTRATION OF THYMIC EXTRACTS

1965 • 77 citations

Effect of phytohemagglutinin and prostaglandins on cyclic AMP synthesis in rat lymph node lymphocytes

1970 • 75 citations

Insulin-Induced Augmentation of Lymphocyte-Mediated Cytotoxicity

1975 • 73 citations

The Human Lymphocyte: A Model for the Study of Insulin-Receptor Interaction

1974 • 72 citations

Changes in histone phosphorylation and associated early metabolic events in pig lymphocyte cultures transformed by phytohaemagglutinin or 6-N,2′-O-dibutyryladenosine 3′:5′-cyclic monophosphate

1971 • 70 citations

Decrease in microviscosity of lymphocyte surface membrar associated with stimulation induced by concanavalin A

1975 • 68 citations

The effect of cyclic nucleotides on purine biosynthesis and the induction of PRPP synthetase during lymphocyte activation

1974 • 67 citations

Thymic factor in human sera demonstrable by a cyclic AMP assay

1976 • 63 citations

Concanavalin a stimulation of rat lymphocyte ATPase

1972 • 63 citations

Drug Receptors and the Haemopoietic Stem Cell

1973 • 61 citations

Variability of the time at which PHA-stimulated lymphocytes initiate DNA synthesis

1973 • 57 citations

Increased mitogenic reactivity of normal spleen cells to T lectins induced by thymus humoral factor (THF)

1975 • 57 citations

Effects of concanavalin A and a succinylated derivative on lymphocyte proliferation and cyclic nucleotide levels.

1976 • 55 citations

DNA binding by adenosine cyclic 3',5'-monophosphate dependent protein kinase from calf thymus nuclei

1975 • 54 citations

The effect of isoproterenol and its analogs upon adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate levels in mouse parotid gland in vivo☆Relationship to the stimulation of DNA synthesis

1974 • 53 citations

Cyclic GMP and Lectin-Induced Lymphocyte Activation

1975 • 50 citations

EARLY EVENTS IN LYMPHOCYTE TRANSFORMATION BY PHYTOHEMAGGLUTININ

1972 • 48 citations

Effects of norepinephrine on cyclic nucleotide levels in the ductus deferens of the rat

1975 • 48 citations

Adenyl Cyclase Activity of Spleen Cells Exposed to Immunoenhancing Synthetic Oligo- and Polynucleotides

1971 • 48 citations

Concanavalin A and the initiation of thymic lymphoblast DNA synthesis and proliferation by a calcium‐dependent increase in cyclic GMP level

1974 • 47 citations

Specific Mitogenic Activity of 8-Br-Guanosine 3′,5′-Monophosphate (Br-Cyclic GMP) on B Lymphocytes

1975 • 47 citations

Early biochemical changes in phytohemagglutinin-stimulated peripheral blood lymphocytes from normal and tumor-bearing rats

1974 • 44 citations

Early changes in the phospholipid metobolism of lymphocytes following stimulation with phytohemagglutinin and with lysolecithin

1971 • 43 citations

ANTIGENIC AND FUNCTIONAL EVIDENCE FOR THE IN VITRO INDUCTIVE ACTIVITY OF THYMOPOIETIN (THYMIN) ON THYMOCYTE PRECURSORS*

1975 • 40 citations

Cyclic AMP-mediated stimulation by calcium of thymocyte proliferation*1

1971 • 39 citations

Differentiation of Thymocytes: Evidence that Induction of the Surface Phenotype Requires Transcription and Translation

1976 • 39 citations

Role of Cyclic AMP in Mitogen Induced Transformation of Human Peripheral Leukocytes

1973 • 39 citations

CYCLIC GMP AND LYMPHOCYTE ACTIVATION

1975 • 39 citations

Antigen-stimulated changes in cyclic nucleotide levels in the mouse.

1975 • 39 citations

Thymopoietin-induced acquisition of responsiveness to T cell mitogens

1975 • 39 citations

The Possible Mediation by Cyclic AMP of the Stimulation of Thymocyte Proliferation by Cyclic GMP

1971 • 38 citations

Protein phosphorylation in human peripheral lymphocytes — Stimulation by phytohemagglutinin and N6 monobutyryl cyclic AMP

1975 • 35 citations

Intracellular Events Involved in the Induction of Immune Competence in Lymphoid Cells by a Thymus Humoral Factor

1975 • 34 citations

THE NATURE AND MECHANISM OF STIMULATION OF IMMUNE RESPONSIVENESS BY THYMUS EXTRACTS*

1975 • 34 citations

The effects of isoproterenol and cyclic adenosine 3',5'-phosphate on phytohemagglutinin-stimulated DNA synthesis in lymphocytes obtained from patients with chronic lymphocytic leukemia.

1970 • 33 citations

Adenosine cyclic 3',5'-monophosphate response to concanavalin A in human lymphocytes. Evidence that the response involves specific carbohydrate receptors on the cell surface

1974 • 28 citations

Effect of Lectins on the Levels of cAMP and cGMP in Guinea Pig Lymphocytes: Early Responses of Lymph Node Cells to Mitogenic and Non-Mitogenic Lectins

1976 • 28 citations

Guanyl Cyclase Activity of Human Blood Lymphocytes

1975 • 26 citations

Norepinephrine Stimulation of Lymphocyte ATPase by an Alpha Adrenergic Receptor Mechanism

1975 • 24 citations

Cyclic GMP and Cyclic AMP in Lymphocyte Metabolism and Proliferation

1974 • 24 citations

THE ROLE OF PHOSPHOLIPIDS IN LYMPHOCYTE ACTIVATION

1975 • 23 citations

Qualitative and quantitative studies on mixed homologous chicken thymus cell cultures.

1970 • 23 citations

Requirements for divalent cations by hormonal mitogens and their interactions with sex steroids

1975 • 23 citations

Lymphocyte activation: The dualistic effect of cAMP

1973 • 22 citations

Activation of Mouse Splenic Lymphocyte Guanylate Cyclase by Calcium Ion1

1976 • 22 citations

Adenosine 3':5'-monophosphate-dependent and independent histone kinases isolated from human tonsillar lymphocytes.

1973 • 21 citations

Adrenergic mechanisms in human lymphocyte metabolism

1971 • 20 citations

Lymphocyte blast transformation. II. The mechanism of action of alpha adrenergic receptor effects.

1971 • 18 citations

Adenosine 3′:5′-monophosphate-dependent an independent histone kinases isolated from human tonsillar lymphocytes

1973 • 17 citations

NATURE AND BIOLOGICAL ACTIVITIES OF THYMUS HORMONES: PROSPECTS FOR THE FUTURE

1975 • 17 citations

Enhanced Transformation of Human Immunocompetent Cells by Dibutyryl Adenosine Cyclic 3′,5′-Monophosphate

1971 • 14 citations

Effects of cyclic GMP upon DNA binding by a calf thymus nuclear protein fraction

1975 • 14 citations

Lymphocyte Blast Transformation

1971 • 14 citations

Cytocidal and cytostatic effects of activated peritoneal leukocytes

1975 • 13 citations

Effect of Cyclic Nucleotides on DNA Synthesis in Mouse Lymphoid Cells

1975 • 13 citations

Alpha adrenergic stimulation of glucose uptake in human erythrocyte, lymphocyte, and lymphoblast*1

1971 • 12 citations

Effects of compounds which inhibit lymphocyte stimulation on the utilization of glucose by leukocytes

1970 • 12 citations

Control of mitogen-induced lymphocyte activation

1975 • 12 citations

Lymphocyte Stimulation by Cyclic AMP, GMP and Related Compounds

1972 • 7 citations

Effects of Cyclic AMP and Theophylline on Mitogen-Induced RNA Synthesis in Human Peripheral Blood Lymphocytes

1973 • 2 citations

Antigen-induced changes in lymphocyte circulatory patterns

1975 • 2 citations