Spinal κ-opioid receptor-mediated antinociception is stimulus-specific

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Analgesia Mediated by a Direct Spinal Action of Narcotics

1976 • 945 citations

U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

1983 • 795 citations

Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat

1976 • 767 citations

Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats

1973 • 523 citations

The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties

1982 • 509 citations

[3H]U-69593 a highly selective ligand for the opioid κ receptor

1985 • 439 citations

In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat.

1984 • 391 citations

Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.

1981 • 390 citations

A CLASSIFICATION OF OPIATE RECEPTORS THAT MEDIATE ANTINOCICEPTION IN ANIMALS

1980 • 346 citations

Bremazocine: A potent, long-acting opiate kappa-agonist

1980 • 314 citations

Immunohistochemical localization of leucine‐enkephalin in the spinal cord of the cat: Enkephalin‐containing marginal neurons and pain modulation

1981 • 215 citations

An opioid benzodiazepine

1982 • 201 citations

Properties of a selective kappa agonist, U-50,488H

1982 • 195 citations

Immunoreactive dynorphin in mammalian spinal cord and dorsal root ganglia.

1981 • 182 citations

Antinociception and paralysis induced by intrathecal dynorphin A.

1985 • 164 citations

Selective receptors for β-endorphin on the rat vas deferens

1979 • 163 citations

Dynorphin A and related peptides administered intrathecally in the rat: a search for putative kappa opiate receptor activity.

1986 • 157 citations

In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord

1982 • 148 citations

Mixed opioid/nonopioid effects of dynorphin and dynorphin related peptides after their intrathecal injection in rats

1983 • 140 citations

U-50488H, a pure kappa receptor agonist with spinal analgesic loci in the mouse

1982 • 139 citations

Dynorphin: Potent analgesic effect in spinal cord of the rat

1982 • 110 citations

Opioid receptor selectivity of dynorphin gene products.

1984 • 99 citations

Characterization of dynorphin A-induced antinociception at spinal level

1985 • 88 citations

Immunoreactive dynorphin B in sacral primary afferent fibers of the cat

1986 • 86 citations

Analgesic effects of μ-, δ- and κ-opiate agonists and, in particular, dynorphin at the spinal level

1983 • 83 citations

Dynorphin induces partially reversible paraplegia in the rat

1983 • 71 citations

Spinal cord dynorphin may modulate nociception via a ℵ-opioid receptor in chronic arthritic rats

1985 • 69 citations

Unexpected opioid activity in a known class of drug

1982 • 64 citations

Further demonstration of kappa opioid binding sites in the brain: evidence for heterogeneity.

1985 • 62 citations

Highly specific opiate receptors for dynorphin-(1–13) in the mouse vas deferens

1980 • 60 citations

Multiple opiate binding sites in rat spinal cord

1982 • 56 citations

Comparison of mu, delta, and kappa opiate binding sites in rat brain and spinal cord

1984 • 56 citations

Analgesia induced by intrathecal injection of dynorphin B in the rat

1984 • 51 citations

Bremazocine is an agonist at K‐opioid receptors and an antagonist at μ‐opioid receptors in the guinea‐pig myenteric plexus

1986 • 50 citations

Benzomorphan binding sites in rat lumbo-sacral spinal cord

1982 • 47 citations

Autoradiographic localization of opiate κ receptors in the rat spinal cord

1983 • 41 citations

Studies on spinal opiate receptor pharmacology. III. Analgetic effects of enkephalin dimers as measured by cutaneous-thermal and visceral-chemical evoked responses

1985 • 31 citations

High affinity [3H]ethylketazocine binding: Evidence for specific κ receptors

1982 • 26 citations

Bremazocine induces antinociception, but prevents opioid-induced constipation and catatonia in rats and precipitates withdrawal in morphine-dependent rats

1984 • 26 citations

Tolerance and cross-tolerance studies with morphine and ethylketocyclazocine

1982 • 25 citations

Differential interaction of opiates to multiple “kappa” binding sites in the guinea-pig lumbo-sacral spinal cord

1982 • 24 citations

OPIATE BINDING SITES IN THE LUMBO-SACRAL SPINAL CORD FROM VARIOUS SPECIES

1981 • 10 citations

Proceedings of the 1982 International Narcotic Research Conference

1982 • 10 citations