Allopurinol-enhanced myocardial protection does not involve xanthine oxidase inhibition or purine salvage

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Ischemic injury in the cat small intestine: Role of superoxide radicals

1982 • 771 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

Allopurinol and oxypurinol are hydroxyl radical scavengers

1987 • 393 citations

The pathophysiology of superoxide: roles in inflammation and ischemia

1982 • 368 citations

Functional compartmentation of ATP and creatine phosphate in heart muscle

1970 • 301 citations

A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues

1989 • 232 citations

Protection of the Ischemic Myocardium: Cardioplegia

1982 • 227 citations

Role of xanthine oxidase inhibitor as free radical scavenger: A novel mechanism of action of allopurinol and oxypurinol in myocardial salvage

1987 • 203 citations

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

1987 • 199 citations

Responses of the ischemic myocardium to allopurinol

1971 • 183 citations

Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs.

1985 • 180 citations

Protection of the Ischemic Myocardium: Cardioplegia

1981 • 166 citations

Formation and release of purine catabolites during hypoperfusion, anoxia, and ischemia

1987 • 143 citations

Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts

1986 • 139 citations

The activity of xanthine oxidase in heart of pigs, guinea pigs, rabbits, rats, and humans

1987 • 133 citations

Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart

1987 • 127 citations

Prevention of free radical-induced myocardial reperfusion injury with allopurinol

1985 • 122 citations

Infarct size limitation by the xanthine oxidase inhibitor, allopurinol, in closed-chest dogs with small infarcts

1985 • 97 citations

Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium

1987 • 93 citations

Allopurinol can act as an electron transfer agent. Is this relevant during reperfusion injury?

1986 • 81 citations

Free Radicals and Cardioplegia: Allopurinol and Oxypurinol Reduce Myocardial Injury Following Ischemic Arrest

1987 • 64 citations

The effect of allopurinol on the degree of early myocardial ischemia

1980 • 64 citations

Xanthine Oxidase is Not Responsible for Reoxygenation Injury in Isolated-Perfused Rat Heart

1987 • 59 citations

A clinical trial of allopurinol (Zyloric) for myocardial protection

1991 • 54 citations

Enhanced purine salvage during allopurinol therapy: an important pharmacologic property in humans.

1981 • 42 citations

Effect of allopurinol (Zyloric) on patients undergoing open heart surgery.

1979 • 42 citations

Effect of allopurinol on tissue ATP, ADP and AMP concentrations in renal ischaemia

1974 • 40 citations

Purine efflux after cardiac ischemia: relevance to allopurinol cardioprotection

1987 • 37 citations

Reverse Phase HPLC For Rapid, Comprehensive Measurement of Nucleotides, Nucleosides and Bases of The Myocardial Adenine Pool

1984 • 33 citations

Xanthine oxidase activity in rat brain

1973 • 29 citations

Myocardial adenine pool depletion and recovery of mechanical function following ischemia

1985 • 25 citations

The xanthine oxidase inhibitor oxypurinol does not limit infarct size in a canine model of 40 minutes of ischemia with reperfusion

1988 • 25 citations

Adenine nucleotide degradation in the human myocardium during cardioplegia

1987 • 16 citations

Myocardial cyclic AMP determinations: The importance of rapidity of sample freezing

1983 • 11 citations

Perfusate calcium: effect on cardiac stability and response to ischemia and reperfusion.

1991 • 9 citations

Effect of Anesthesia on Myocardial Tolerance to Ischemia

1974 • 6 citations