Differential cross-regulation of TrkA and TrkC tyrosine kinase receptors with p75

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Regulation of Cell Survival by Secreted Proneurotrophins

2001 • 1,618 citations

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75

1996 • 768 citations

Neurotrophin signal transduction by the Trk receptor

1994 • 511 citations

The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death

1998 • 500 citations

Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR

1999 • 452 citations

The TrkB-Shc Site Signals Neuronal Survival and Local Axon Growth via MEK and PI3-Kinase

2000 • 431 citations

The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho

2002 • 395 citations

High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.

1994 • 313 citations

The many faces of p75NTR

2002 • 309 citations

Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473

2000 • 268 citations

Nerve growth factor: two receptors, multiple functions

1998 • 232 citations

The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor TrkA

1999 • 231 citations

The Cytoplasmic and Transmembrane Domains of the p75 and Trk A Receptors Regulate High Affinity Binding to Nerve Growth Factor

2001 • 227 citations

Ceramide Signaling Downstream of the p75 Neurotrophin Receptor Mediates the Effects of Nerve Growth Factor on Outgrowth of Cultured Hippocampal Neurons

1999 • 192 citations

p75NTR and apoptosis: Trk-dependent and Trk-independent effects

1997 • 172 citations

Neurotrophin receptors: mediators of life and death

1998 • 161 citations

The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway

2001 • 148 citations

Expression of TrkA, TrkB and TrkC in human neuroblastomas.

1997 • 145 citations

?-amyloid binds to p75NTRand activates NF?B in human neuroblastoma cells

1998 • 144 citations

p75NTR: A study in contrasts

1998 • 133 citations

Nerve Growth Factor-induced p75-mediated Death of Cultured Hippocampal Neurons Is Age-dependent and Transduced through Ceramide Generated by Neutral Sphingomyelinase

2002 • 127 citations

Nerve Growth Factor Activation of Nuclear Factor κB through Its p75 Receptor Is an Anti-apoptotic Signal in RN22 Schwannoma Cells

2000 • 106 citations

p75 Co-receptors Regulate Ligand-dependent and Ligand-independent Trk Receptor Activation, in Part by Altering Trk Docking Subdomains

2001 • 98 citations

Optimal Nerve Growth Factor Trophic Signals Mediated by Synergy of TrkA and p75 Receptor-Specific Ligands

1997 • 94 citations

A TrkA-selective, Fast Internalizing Nerve Growth Factor-Antibody Complex Induces Trophic but Not Neuritogenic Signals

1998 • 87 citations

Neural Differentiation Promoted by Truncated trkC Receptors in Collaboration with p75NTR

1998 • 86 citations

Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons

2002 • 85 citations

Nerve growth factor signaling of p75 induces differentiation and ceramide‐mediated apoptosis in Schwann cells cultured from degenerating nerves

2001 • 80 citations

Brain-derived Neurotrophic Factor Binding to the p75 Neurotrophin Receptor Reduces TrkA Signaling While Increasing Serine Phosphorylation in the TrkA Intracellular Domain

1997 • 79 citations

The Neurotrophin Receptor p75 Binds Neurotrophin-3 on Sympathetic Neurons with High Affinity and Specificity

1997 • 77 citations

NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR

1998 • 63 citations

Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75NTR-dependent sphingolipid signaling pathways

2001 • 59 citations

Cell Cycle Phase-Specific Surface Expression of Nerve Growth Factor Receptors TrkA and p75^NTR

1998 • 57 citations

The p75 Neurotrophin Receptor (p75NTR) Alters Tumor Necrosis Factor-mediated NF-κB Activity under Physiological Conditions, but Direct p75NTR-mediated NF-κB Activation Requires Cell Stress

1999 • 48 citations

p75 Reduces TrkB Tyrosine Autophosphorylation in Response to Brain-derived Neurotrophic Factor and Neurotrophin 4/5

2000 • 47 citations

Deletions in the Extracellular Domain of Rat TrkA Lead to an Altered Differentiative Phenotype in Neurotrophin Responsive Cells

1996 • 41 citations

p75-Nerve Growth Factor as an Antiapoptotic Complex: Independence versus Cooperativity in Protection from Enediyne Chemotherapeutic Agents

2002 • 35 citations

Neurotrophin dependence mediated by p75NTR: contrast between rescue by BDNF and NGF

1999 • 28 citations

Novel functional interactions between Trk kinase and p75 neurotrophin receptor in neuroblastoma cells

2002 • 24 citations

PC12^nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor

2002 • 22 citations

Analysis of the NF-κB and PI 3-Kinase/Akt Survival Pathways in Nerve Growth Factor-Dependent Neurons

2001 • 21 citations

Growth arrest of PC12 cells by nerve growth factor is dependent on the phosphatidylinositol 3‐kinase/Akt pathway via p75 neurotrophin receptor

2003 • 21 citations

Monoclonal antibody to human trk-A: diagnostic and therapeutic potential in neuroblastoma

1997 • 11 citations