Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

2003 • 3,943 citations

Protein backbone angle restraints from searching a database for chemical shift and sequence homology.

1999 • 2,966 citations

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

2002 • 2,424 citations

Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes

2003 • 2,406 citations

A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR

2002 • 1,799 citations

P<scp>ROTOFIBRILS</scp>, P<scp>ORES</scp>, F<scp>IBRILS, AND</scp> N<scp>EURODEGENERATION</scp>: Separating the Responsible Protein Aggregates from The Innocent Bystanders

2003 • 1,620 citations

Amyloid pores from pathogenic mutations

2002 • 1,260 citations

Eight prion strains have PrPSc molecules with different conformations

1998 • 1,236 citations

Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways

2002 • 1,218 citations

Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity

1996 • 857 citations

The protofilament structure of insulin amyloid fibrils

2002 • 811 citations

Conformational variations in an infectious protein determine prion strain differences

2004 • 782 citations

Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition

2003 • 713 citations

Observation of metastable Aβ amyloid protofibrils by atomic force microscopy

1997 • 692 citations

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies

2002 • 582 citations

High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy

2004 • 502 citations

From the globular to the fibrous state: protein structure and structural conversion in amyloid formation

1998 • 452 citations

Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent

1992 • 440 citations

Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

1995 • 393 citations

Progress towards a molecular-level structural understanding of amyloid fibrils

2004 • 377 citations

Structural and Dynamic Features of Alzheimer's Aβ Peptide in Amyloid Fibrils Studied by Site-directed Spin Labeling

2002 • 372 citations

Mapping Aβ Amyloid Fibril Secondary Structure Using Scanning Proline Mutagenesis

2003 • 372 citations

Use of Chemical Shifts in Macromolecular Structure Determination

2002 • 360 citations

Supramolecular Structure in Full-Length Alzheimer's β-Amyloid Fibrils: Evidence for a Parallel β-Sheet Organization from Solid-State Nuclear Magnetic Resonance

2002 • 304 citations

Studies on the in Vitro Assembly of Aβ 1–40: Implications for the Search for Aβ Fibril Formation Inhibitors

2000 • 270 citations

Supramolecular Structural Constraints on Alzheimer's β-Amyloid Fibrils from Electron Microscopy and Solid-State Nuclear Magnetic Resonance

2002 • 262 citations

Frequency Selective Heteronuclear Dipolar Recoupling in Rotating Solids: Accurate¹³C−¹⁵N Distance Measurements in Uniformly¹³C,¹⁵N-labeled Peptides

2001 • 242 citations

Structure of the β-Amyloid_(10-35) Fibril

2000 • 224 citations

Structural Features of the Aβ Amyloid Fibril Elucidated by Limited Proteolysis

2001 • 198 citations

Conformational diversity in a yeast prion dictates its seeding specificity

2001 • 143 citations