Phorbol ester‐induced change in astrocyte morphology: Correlation with protein kinase C activation and protein phosphorylation

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

1979 • 727 citations

Down-regulation of protein kinase C is due to an increased rate of degradation

1987 • 442 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve I. Cell proliferation

1976 • 364 citations

Observations on the astrocyte response to a cerebral stab wound in adult rats

1985 • 354 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

Tumor promoter-induced changes in the permeability of epithelial cell tight junctions

1981 • 185 citations

Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.

1986 • 183 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Phorbol myristate acetate stimulates microtubule and 10-nm filament extension and lysosome redistribution in mouse macrophages.

1980 • 135 citations

Lactation-associated redistribution of the glial fibrillary acidic protein within the supraoptic nucleus

1985 • 112 citations

Light microscopic identification of immature glial cells in semithin sections of the developing mouse corpus callosum.

1976 • 103 citations

Growth stimulation of human diploid fibro‐blasts by the tumor promoter, 12‐0‐tetradecanoyl‐phorbol‐13‐acetate

1974 • 101 citations

Protein Kinase C in Primary Astrocyte Cultures: Cytoplasmic Localization and Translocation by a Phorbol Ester

1988 • 92 citations

Protein kinase C in astrocytes: a determinant of cell morphology

1986 • 82 citations

Calcium-activated, phospholipid-dependent protein kinase and protein substrates in primary cultures of astrocytes

1986 • 62 citations

THE ENZYMIC HYDROLYSIS OF PHOSPHATIDYL INOSITOL BY GUINEA PIG BRAIN:

1969 • 41 citations

Protein Phosphorylation in Astrocytes Mediated by Protein Kinase C: Comparison with Phosphorylation by Cyclic AMP‐Dependent Protein Kinase

1989 • 27 citations

TPA induces subcellular translocation and subsequent down-regulation of both phorbol ester binding and protein kinase C activities in MCF-7 cells

1987 • 26 citations

[26] Ca2+-dependent neutral protease and proteolytic activation of Ca2+-activated, phospholipid-dependent protein kinase

1983 • 23 citations