Opioid Substitution to Improve the Effectiveness of Chronic Noncancer Pain Control: A Chart Review

Chronic use of opioid analgesics in non-malignant pain: Report of 38 cases

1986 • 879 citations

The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions

1990 • 574 citations

Opioid therapy for chronic nonmalignant pain: a review of the critical issues

1996 • 524 citations

Randomised trial of oral morphine for chronic non-cancer pain

1996 • 395 citations

Long-term oral opioid therapy in patients with chronic nonmalignant pain

1992 • 368 citations

Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions.

1997 • 288 citations

Individual variability in the response to different opioids: report of five cases

1992 • 245 citations

Cancer pain: management

1992 • 234 citations

Morphine metabolites

1997 • 227 citations

Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia

1992 • 202 citations

A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer

1986 • 199 citations

Long-term opioid therapy: Assessment of consequences and risks

1996 • 180 citations

Opioid Analgesics

1996 • 171 citations

Medication misuse, abuse and dependence in chronic pain patients

1997 • 146 citations

Transgenic analysis of central nervous system development and regeneration

1997 • 145 citations

Clinical efficacy of methadone in patients refractory to other μ-opioid receptor agonist analgesics for management of terminal cancer pain. Case presentations and discussion of incomplete cross-tolerance among opioid agonist analgesics

1993 • 108 citations

Differential Cross-tolerance Between Intrathecal Morphine and Sufentanil in the Rat

1990 • 98 citations

Neurophysiology of opioid poorly responsive pain.

1994 • 83 citations

Genetic influences in opioid analgesic sensitivity in mice

1991 • 80 citations

Cancer pain management current strategy

1993 • 74 citations

Suppression of Nociceptive Responses by Spinal Mu Opioid Agonists

1993 • 68 citations

Chronic Nonmalignant Pain Treated with Long-Term Oral Narcotic Analgesics

1992 • 53 citations

Opiate and Opioid Use in Patients With Refractory Headache

1994 • 44 citations

Tolerance and dependence to opiates

1997 • 31 citations

Opioid Treatment of Chronic Nonmalignant Pain1

1997 • 29 citations

Opioid Treatment of Chronic Nonmalignant Pain1

1997 • 29 citations

Chronic headache: appropriate use of opiate analgesics.

1994 • 18 citations