Opioid therapy for chronic nonmalignant pain: a review of the critical issues

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Advances in Pain Research and Therapy

1980 • 2,255 citations

[Drug addiction and drug abuse].

1969 • 1,466 citations

The Pharmacological Basis of Therapeutics

1986 • 1,413 citations

The NIMH Epidemiologic Catchment Area Program

1984 • 1,236 citations

Opioid analgesics and antagonists

1996 • 1,193 citations

Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain

1988 • 996 citations

Advances in Pain Research and Therapy

1985 • 963 citations

Substance Abuse: A Comprehensive Textbook

1992 • 890 citations

Chronic use of opioid analgesics in non-malignant pain: Report of 38 cases

1986 • 879 citations

A validation study of the WHO method for cancer pain relief

1987 • 766 citations

Cancer pain relief and palliative care

1992 • 657 citations

Opioid pseudoaddiction — an iatrogenic syndrome

1989 • 629 citations

Opioid Peptides Mediate the Suppressive Effect of Stress on Natural Killer Cell Cytotoxicity

1984 • 611 citations

The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions

1990 • 574 citations

Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia

1991 • 494 citations

Central nervous system excitatory effects of meperidine in cancer patients

1983 • 409 citations

Randomised trial of oral morphine for chronic non-cancer pain

1996 • 395 citations

Long-term oral opioid therapy in patients with chronic nonmalignant pain

1992 • 368 citations

18. Cancer Pain Relief and Palliative Care

2010 • 366 citations

Drug Abuse, Dependence, and Addiction in Chronic Pain Patients

1992 • 361 citations

Heritability of substance abuse and antisocial behavior: A study of monozygotic twins reared apart

1990 • 339 citations

Management of pain during debridement: a survey of U.S. burn units

1982 • 331 citations

A 20-Year Follow-Up of New York Narcotic Addicts

1973 • 327 citations

The cognitive effects of the administration of narcotic analgesics in patients with cancer pain

1989 • 275 citations

Methadone—A Reevaluation

1973 • 267 citations

Physiological parameters of morphine dependence in man—Tolerance, early abstinence, protracted abstinence

1969 • 264 citations

Cancer pain management according to WHO analgesic guidelines

1990 • 262 citations

PATTERNS OF NARCOTIC DRUG USE IN A CANCER PAIN CLINIC*

1981 • 257 citations

The management of cancer pain

1994 • 251 citations

The Edmonton staging system for cancer pain: preliminary report

1989 • 247 citations

Individual variability in the response to different opioids: report of five cases

1992 • 245 citations

Medical Safety and Side Effects of Methadone in Tolerant Individuals

1973 • 242 citations

Multiple Mechanisms of withdrawal from Opioid Drugs

1984 • 241 citations

Cancer pain. Epidemiology and syndromes

1989 • 240 citations

Long-term pain relief produced by intrathecal morphine infusion in 53 patients

1990 • 227 citations

Pain, depression, and illness behavior in a Pain Clinic population

1977 • 227 citations

How Permanent Was Vietnam Drug Addiction?

1974 • 211 citations

Morphine differentially affects the sensory and affective pain ratings in neurogenic and idiopathic forms of pain

1991 • 209 citations

Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia

1992 • 202 citations

DEVELOPMENT AND LOSS OF TOLERANCE TO MORPHINE IN THE RAT AFTER SINGLE AND MULTIPLE INJECTIONS.

1964 • 200 citations

Opioid responsiveness of cancer pain syndromes caused by neuropathic or nociceptive mechanisms

1994 • 199 citations

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine

1990 • 196 citations

Opioid-mediated suppression of interferon-gamma production by cultured peripheral blood mononuclear cells.

1987 • 186 citations

Evaluation of WHO analgesic guidelines for cancer pain in a hospital-based palliative care unit

1988 • 175 citations

The relationship of pain and symptom management to patient requests for physician-assisted suicide

1991 • 172 citations

Drug abuse and dependency in patients with chronic pain.

1979 • 162 citations

Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial

1995 • 162 citations

American Opiophobia:

1985 • 160 citations

Pain, opioid use, and survival in hospitalized patients with advanced cancer.

1992 • 158 citations

Clarification and Standardization of Substance Abuse Terminology

1988 • 157 citations

A long-term survey of morphine in cancer pain patients

1992 • 152 citations

Long-term use of narcotic/antidepressant medication in the management of phantom limb pain

1986 • 146 citations

Personality Characteristics of Narcotic Addicts as Indicated by the MMPI

1960 • 145 citations

Consequences of the 1989 New York State Triplicate Benzodiazepine Prescription Regulations

1991 • 145 citations

MEDICAL COMPLICATIONS IN METHADONE PATIENTS

1978 • 144 citations

Follow-up Evaluation of Treatment of Drug Abuse During 1969 to 1972

1979 • 143 citations

Opioid use in the treatment of chronic pain: Assessment of addiction

1993 • 142 citations

Opioids in Neuropathic Pain

2005 • 141 citations

Long-term use of opioid analgesics for the treatment of chronic pain of nonmalignant origin

1993 • 139 citations

CHANGES IN PERSONALITY AND SUBJECTIVE EXPERIENCE ASSOCIATED WITH THE CHRONIC ADMINSTRATION AND WITHDRAWAL OF OPIATES

1969 • 133 citations

An epidemiological follow-up survey of persistent pain sufferers in a group family practice and specialty pain clinic

1989 • 127 citations

Opioid analgesics in the treatment of chronic intractable pain of non-neoplastic origin

1984 • 126 citations

Narcotic Analgesics in Anesthesiology

1982 • 124 citations

Drug utilization patterns in chronic pain patients

1982 • 123 citations

Predictive factors in advanced cancer pain treated only by analgesics

1992 • 123 citations

Clinical experience with diamorphine in advanced malignant disease.

1974 • 122 citations

Self-reported vs. actual use of medications in chronic pain patients

1982 • 119 citations

Narcotic maintenance for chronic pain

1983 • 118 citations

Long-term use of narcotic analgesics in chronic pain

1984 • 111 citations

An MMPI Factor Analytic Study of Alcoholics, Narcotic Addicts and Criminals

1962 • 110 citations

A comparison of cognitive impairment due to benzodiazepines and to narcotics

1980 • 110 citations

Drug-induced headache.

1990 • 110 citations

Opioid Dependence: Mechanisms and Treatment

1980 • 110 citations

The Care of Patients With Severe Chronic Pain in Terminal Illness

1984 • 104 citations

Treating Sickle Cell Pain like Cancer Pain

1992 • 97 citations

The impact of a comprehensive evaluation in the management of cancer pain

1991 • 94 citations

Opioid sensitivity of chronic pain: a patient‐controlled analgesia method

1992 • 93 citations

Pain, sedation and reaction time during long-term treatment of cancer patients with oral and epidural opioids

1989 • 91 citations

Prolonged morphine self-administration and addiction liability. Evaluation of two theories in a bone marrow transplant unit

1989 • 88 citations

Illness behavior and depression compared in pain center and private practice patients

1979 • 86 citations

Delirium as a contributing factor to “crescendo” pain: Three case reports

1994 • 83 citations

Prescription medication dependence and neuropsychologic function

1984 • 80 citations

Drug Dependency in Patients with Chronic Headaches

1977 • 79 citations

Chronic Pain Syndrome

1984 • 75 citations

Epidemiologic comparison of persistent pain sufferers in a specialty pain clinic and in the community.

1986 • 75 citations

Narcotic Addiction, Physical Dependence and Relapse

1972 • 74 citations

Wisconsin physicians' knowledge and attitudes about opioid analgesic regulations.

1991 • 67 citations

EXPERIENCE IN THE MANAGEMENT OF PATIENTS MEDICALLY ADDICTED TO NARCOTICS

1954 • 67 citations

Daily Chronic Headache

1990 • 66 citations

Morphine-induced immune alterations in vivo

1990 • 65 citations

Drug Therapy for Severe, Chronic Pain in Terminal Illness

1983 • 64 citations

Chronic morphine administration impairs cell-mediated immune responses in swine.

1992 • 64 citations

Chronic opioid treatment of intractable, non-malignant pain.

1988 • 63 citations

Chronic pain exacerbated by long-term narcotic use in patients with nonmalignant disease: clinical syndrome and treatment.

1978 • 59 citations

Acute opiate tolerance in man

1981 • 58 citations

Cerebral Effects of Long-Term Oral Opioids in Cancer Patients Measured by Continuous Reaction Time

1990 • 58 citations

Drug-Induced Headache

1990 • 57 citations

Medication management in patients with chronic non-malignant pain. A review of the use of a drug withdrawal protocol

1986 • 56 citations

Effect of a triplicate prescription law on prescribing of Schedule II drugs

1984 • 56 citations

Substance dependence and chronic pain: Experience with treatment and follow-up results

1986 • 55 citations

Problems with the use of oxycodone compound in patients with chronic pain

1981 • 54 citations

Substance dependence and chronic pain: Profile of 50 patients treated in an alcohol and drug dependence unit

1986 • 52 citations

The Need to Redefine Addiction

1983 • 50 citations

Opioids in Nonmalignant Pain

1991 • 49 citations

Cognitive Functioning under Moderate and Low Dosage Methadone Maintenance

1976 • 48 citations

Implementation of a formal treatment agreement for outpatient management of chronic nonmalignant pain with opioid analgesics

1995 • 46 citations

Proceedings of the First World Congress on Pain

1976 • 46 citations

Neurobiology of Opioids

1991 • 46 citations

Encyclopedia of drugs and alcohol

1995 • 45 citations

Opiate and Opioid Use in Patients With Refractory Headache

1994 • 44 citations

Morphine depression of T cell E-rosetting: definition of the process.

1985 • 42 citations

Opiate receptor mediated regulation of the immune response in vivo.

1987 • 41 citations

NEUROPSYCHOLOGICAL IMPAIRMENT IN OPIATE ADDICTS: RISK FACTORS*

1981 • 40 citations

Digit-symbol performance in methadone-treated ex-heroin addicts

1976 • 39 citations

Immunosuppression to Tetanus Toxoid Induced by Implanted Morphine Pellets

1990 • 37 citations

Opioids, chronic pain, and the law

1993 • 36 citations

Prognostic variability among chronic pain patients: implications for study design, interpretation, and reporting.

1988 • 35 citations

Effect of the requirement for triplicate prescriptions for benzodiazepines in New York State

1991 • 34 citations

Prescription Drug Diversion Control and Medical Practice

1992 • 33 citations

Cancer Pain Relief

1985 • 33 citations

Optimizing opioid treatment of postoperative pain.

1990 • 33 citations

Non-cardiogenic pulmonary edema after narcotic treatment for cancer pain

1989 • 32 citations

Interdisciplinary Rehabilitation of Low Back Pain

1990 • 32 citations

Narcotic Analgesics in Anesthesiology.

1982 • 31 citations

Interdisciplinary rehabilitation of low back pain

1989 • 30 citations

Morphine, experimental pain, and psychological reactions

1981 • 26 citations

Defining the “Chronic Pain Syndrome”

1985 • 25 citations

Opioids, pain, and behavioral outcomes

1992 • 23 citations

Physician perception of a triplicate prescription law

1985 • 23 citations

Prescribing Practices for Pain in Drug Dependence:

1985 • 23 citations

Experience with oral morphine for cancer pain relief

1989 • 20 citations

General Problems of Drug Abuse and Drug Dependence

1977 • 17 citations

Narcotics for chronic pain yes or no? A useless dichotomy

1992 • 17 citations

Influence of narcotic drugs on highway safety°

1976 • 14 citations

Defining the “chronic pain syndrome”: An epidemiological method

1984 • 14 citations

Chronic opioid therapy for nonmalignant pain from models to practice

1992 • 13 citations

The effect of drug regulation on the management of cancer pain.

1991 • 13 citations

Prescription drug-induced organic brain syndrome

1978 • 13 citations

Response to Controversy Corner

1991 • 12 citations

The psychosocial impact of opioid treatment

1992 • 10 citations

Is the Therapeutic Use of Opioids Adversely Affected by Prejudice and Law?

1991 • 10 citations

Experimental Heroin Users: An Epidemiologic and Psychosocial Approach

1977 • 8 citations

Existing methods to identify retail drug diversion.

1993 • 6 citations

Deleted Work

1955 • 0 citations