Chemoenzymatic Synthesis of N-Ras Lipopeptides

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

1995 • 663 citations

Bioconjugate techniques

1997 • 642 citations

The pathway to signal achievement

1993 • 563 citations

Molecular cell biology 3.0

1996 • 528 citations

Houben—Weyl - Methoden der Organischen Chemie

1974 • 444 citations

Activation and depalmitoylation of Gsα

1994 • 336 citations

Doubly-lipid-modified protein sequence motifs exhibit long-lived anchorage to lipid bilayer membranes

1995 • 294 citations

Signal-Transduction Therapy. A Novel Approach to Disease Management

1994 • 188 citations

A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling.

1994 • 158 citations

Altered phosphorylation and desensitization patterns of a human beta 2-adrenergic receptor lacking the palmitoylated Cys341.

1993 • 158 citations

Understanding covalent modifications of proteins by lipids: where cell biology and biophysics mingle

1997 • 147 citations

Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting.

1995 • 141 citations

Activation of c-Raf-1 by Ras and Src through different mechanisms: activationin vivoandin vitro

1997 • 140 citations

Allyl esters as carboxy protecting groups in the synthesis of O-glycopeptides

1989 • 130 citations

Signal‐Transduction Therapy

1994 • 129 citations

S-Acylation and Plasma Membrane Targeting of the Farnesylated Carboxyl-Terminal Peptide of N-ras in Mammalian Fibroblasts

1997 • 127 citations

Preparation of oligomer‐free N^α‐Fmoc and N^α‐urethane amino acids

1989 • 116 citations

The human and simian immunodeficiency virus envelope glycoprotein transmembrane subunits are palmitoylated.

1995 • 96 citations

Design of Antitumor Prodrugs: Substrates for Antibody Targeted Enzymes

1994 • 91 citations

Lipid-modified, cysteinyl-containing peptides of diverse structures are efficiently S-acylated at the plasma membrane of mammalian cells.

1996 • 71 citations

Chemoenzymatic Synthesis of a Characteristic Phosphorylated and Glycosylated Peptide Fragment of the Large Subunit of Mammalian RNA Polymerase II

1997 • 60 citations

Effects of Carboxy-Terminal Truncation on the Stability and G Protein-Coupling Activity of Bovine Rhodopsin

1994 • 56 citations

Post-translational Modification of H-Ras Is Required for Activation of, but Not for Association with, B-Raf

1996 • 54 citations

Organische Synthese und biologische Signaltransduktion

1998 • 53 citations

Chemoenzymatic synthesis of O-glycopeptides carrying the tumor associated TN-antigen structure

1993 • 37 citations

Enzymatische Synthese von Peptiden undRas-Lipopeptiden unter Verwendung des Cholinesters als löslichkeitsvermittelnder Schutz- und Aktivierungsgruppe

1996 • 34 citations

Synthese des palmitoylierten und farnesylierten C‐terminalen Lipohexapeptids des menschlichen N‐Ras‐Proteins mit Hilfe einer enzymatisch abspaltbaren Urethanschutzgruppe

1995 • 32 citations

Localization of the Palmitoylation Site in the Transmembrane Protein p12E of Friend Murine Leukaemia Virus

1995 • 32 citations

Groupements protecteurs benzyloxycarbonyles substitues alcalinolabiles

1978 • 31 citations

Selective enzymatic removal of protecting groups: The phenylacetamide as amino protecting group in phosphopeptide synthesis

1996 • 30 citations

Acylation of viral glycoproteins: structural requirements for palmitoylation of transmembrane proteins

1995 • 30 citations

Synthesis of characteristic lipopeptides of the human N-Ras protein and their evaluation as possible inhibitors of protein farnesyl transferase

1997 • 25 citations

Acetylesterase from orange peel as biocatalyst for the chemo- and regioselective deprotection of carbohydrates

1994 • 19 citations

Studies on the Enzymatic Hydrolysis of Amino Acid Carbamates

1987 • 18 citations

Asymmetric Enzymatic Reduction of Lipophilic Ketones in Aqueous Solution Containing Cyclodextrins

1997 • 16 citations

Selective Enzymatic Removal of Protecting Groups from Phosphopeptides: Chemoenzymatic Synthesis of a Characteristic Phosphopeptide Fragment of the Raf-1 Kinase

1997 • 16 citations

Chemoenzymatic Synthesis of a Characteristic Phosphopeptide Fragment of the Raf-1 Kinase

1997 • 15 citations

Chemoenzymatische Synthese fluoreszierender N‐Ras‐Lipopeptide und ihre Verwendung bei In‐vivo‐Studien zur Membranlokalisierung

1997 • 13 citations

Relation between the structure of alliin analogues and their inhibitory effect on platelet aggregation

1985 • 12 citations

Microbial hydrolysis of amino acid carbamates

1988 • 9 citations