Adenovirus-mediated gene transfer

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

1993 • 1,578 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

Human gene therapy comes of age

1992 • 927 citations

An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain

1993 • 746 citations

Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo

1991 • 743 citations

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

1988 • 606 citations

A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

1993 • 588 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

Site-Specific Gene Expression in Vivo by Direct Gene Transfer into the Arterial Wall

1990 • 573 citations

Human gene therapy

1992 • 559 citations

Transfer of a foreign gene into the brain using adenovirus vectors

1993 • 538 citations

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice.

1993 • 531 citations

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

1992 • 483 citations

Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice

1993 • 455 citations

Adenovirus–mediated in vivo gene transfer and expression in normal rat liver

1992 • 451 citations

Recombinant Gene Expression in Vivo Within Endothelial Cells of the Arterial Wall

1989 • 445 citations

Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles.

1991 • 425 citations

Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors

1993 • 387 citations

Development of adenovirus vectors for the expression of heterologous genes.

1988 • 386 citations

Expression of recombinant genes in myocardium in vivo after direct injection of DNA.

1990 • 364 citations

A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia.

1991 • 348 citations

Virus-Receptor Interaction in an Adenovirus System

1968 • 343 citations

Implantation of Vascular Grafts Lined with Genetically Modified Endothelial Cells

1989 • 342 citations

Seeding of intravascular stents with genetically engineered endothelial cells.

1989 • 328 citations

Evaluation of the Transfer and Expression in Mice of an Enzyme-Encoding Gene Using a Human Adenovirus Vector

1990 • 325 citations

Adenovirus as an expression vector in muscle cells in vivo.

1992 • 301 citations

Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants.

1991 • 288 citations

Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer.

1993 • 199 citations

Evidence for a repeating cross-beta sheet structure in the adenovirus fibre.

1983 • 199 citations

Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells.

1992 • 180 citations

Hormonal modulation of a gene injected into rat heart in vivo.

1991 • 180 citations

Eukaryotic viral vectors

1982 • 177 citations

Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus)

1993 • 173 citations

Immunization with Live Types 7 and 4 Adenovirus Vaccines. II. Antibody Response and Protective Effect against Acute Respiratory Disease Due to Adenovirus Type 7

1971 • 171 citations

Low level in vivo gene transfer into the arterial wall through a perforated balloon catheter.

1992 • 159 citations

Direct in vivo gene transfer into the coronary and peripheral vasculatures of the intact dog.

1991 • 144 citations

Use of Human Adenovirus-based Vectors for Antigen Expression in Animals

1989 • 122 citations

Gene transfer into coronary arteries of intact animals with a percutaneous balloon catheter.

1992 • 119 citations

Transduction of a foreign histocompatibility gene into the arterial wall induces vasculitis.

1992 • 103 citations

In vitro and in vivo synthesis of the hepatitis B virus surface antigen and of the receptor for polymerized human serum albumin from recombinant human adenoviruses.

1985 • 86 citations

Immunization by Selective Infection With Type 4 Adenovirus Grown in Human Diploid Tissue Culture

1966 • 81 citations

Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression.

1986 • 77 citations

Helper-Free Adenovirus Type 5 Vectors

1982 • 61 citations

Adenovirus-human immunodeficiency virus (HIV) envelope recombinant vaccines elicit high-titered HIV-neutralizing antibodies in the dog model.

1992 • 50 citations

Helper Independent Recombinant Adenovirus Vectors: Expression of HIVenvor HBV Surface Antigen

1990 • 7 citations