Immunopathology of human immunodeficiency virus infection in the gastrointestinal tract

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 ⁺ T Cells

1995 • 2,890 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

The Immunopathogenesis of Human Immunodeficiency Virus Infection

1993 • 1,194 citations

Human naive and memory T cells

1988 • 793 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

Epithelial Cell Specialization within Human Peyer's Patches: An Ultrastructural Study of Intestinal Lymphoid Follicles

1974 • 757 citations

How Does HIV Cause AIDS?

1993 • 668 citations

Enteropathy Associated with the Acquired Immunodeficiency Syndrome

1984 • 585 citations

Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen.

1985 • 545 citations

Lymphoid organs function as major reservoirs for human immunodeficiency virus.

1991 • 489 citations

Ability of HIV to Promote a T _H 1 to T _H 0 Shift and to Replicate Preferentially in T _H 2 and T _H 0 Cells

1994 • 482 citations

Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.

1990 • 443 citations

Intracellular neutralization of virus by immunoglobulin A antibodies.

1992 • 438 citations

Lack of Evidence for the Dichotomy of T_H1 and T_H2 Predominance in HIV-Infected Individuals

1994 • 434 citations

Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine.

1988 • 404 citations

HUMAN IMMUNODEFICIENCY VIRUS DETECTED IN BOWEL EPITHELIUM FROM PATIENTS WITH GASTROINTESTINAL SYMPTOMS

1988 • 396 citations

Small Intestinal Structure and Function in Patients Infected with Human Immunodeficiency Virus (HIV): Evidence for HIV-Induced Enteropathy

1989 • 374 citations

A three-tiered view of the role of IgA in mucosal defense

1993 • 374 citations

M Cell Transport of Vibrio cholerae from the Intestinal. Lumen into Peyer's Patches: A Mechanism for Antigen Sampling and for Microbial Transepithelial Migration

1986 • 349 citations

The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA.

1991 • 346 citations

RISK FACTORS FOR SEROCONVERSION TO HUMAN IMMUNODEFICIENCY VIRUS AMONG MALE HOMOSEXUALS

1987 • 308 citations

CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual.

1991 • 279 citations

HIV-1 Reverse Transcriptase Is a Target for Cytotoxic T Lymphocytes in Infected Individuals

1988 • 270 citations

Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys

1995 • 252 citations

Galactosyl ceramide (or a closely related molecule) is the receptor for human immunodeficiency virus type 1 on human colon epithelial HT29 cells

1992 • 238 citations

The Effect of Cytokines and Pharmacologic Agents on Chronic HIV Infection

1992 • 237 citations

THE CONTAMINATED DROP

1965 • 237 citations

Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus

1987 • 235 citations

The Immunopathogenesis of HIV Infection

1989 • 233 citations

CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor

1990 • 228 citations

A TATA box implicated in E1A transcriptional activation of a simple adenovirus 2 promoter

1987 • 227 citations

Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection.

1993 • 217 citations

Serologic and Immunologic Studies in Patients With AIDS in North America and Africa

1987 • 212 citations

AIDS Enteropathy: Occult Enteric Infections and Duodenal Mucosal Alterations in Chronic Diarrhea

1991 • 210 citations

Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Berlin Diarrhea/Wasting Syndrome Study Group.

1995 • 208 citations

Transepithelial transport of HIV-1 by intestinal M cells: a mechanism for transmission of AIDS.

1991 • 204 citations

ACQUIRED IMMUNODEFICIENCY SYNDROME WITH SEVERE GASTROINTESTINAL MANIFESTATIONS IN HAITI

1983 • 204 citations

Exercise Thallium-201 Scintigraphy in the Diagnosis and Prognosis of Coronary Artery Disease

1990 • 200 citations

Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men.

1990 • 198 citations

Small Intestinal Injury and Parasitic Diseases in AIDS

1990 • 196 citations

Detection of HIV-1 RNA in the Lamina Propria of Patients with AIDS and Gastrointestinal Disease

1989 • 195 citations

Jejunal enteropathy associated with human immunodeficiency virus infection: quantitative histology.

1989 • 172 citations

T cell differentiation antigens on lymphocytes in the human intestinal lamina propria.

1992 • 165 citations

Lymphocytes isolated from the intestinal lamina propria of normal nonhuman primates have increased expression of genes associated with T-cell activation

1988 • 163 citations

Loss of mucosal CD4 lymphocytes is an early feature of HIV infection

1993 • 154 citations

Intestinal infections in patients with acquired immunodeficiency syndrome

1989 • 142 citations

Isotype specificity of helper T cell clones. Peyer's patch Th cells preferentially collaborate with mature IgA B cells for IgA responses.

1984 • 136 citations

Transmission of Human Immunodeficiency Virus from Monocytes to Epithelia

1991 • 127 citations

Mucosal T cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venereum proctitis in nonhuman primates

1988 • 124 citations

Abnormalities in Intestinal Mucosal T Cells in Homosexual Populations Including Those With the Lymphadenopathy Syndrome and Acquired Immunodeficiency Syndrome

1986 • 122 citations

Serologic and immunologic studies in patients with AIDS in North America and Africa. The potential role of infectious agents as cofactors in human immunodeficiency virus infection

1987 • 119 citations

Intestinal mucosal inflammation associated with human immunodeficiency virus infection

1993 • 119 citations

Human immunodeficiency virus infection of enterocytes and mononuclear cells in human jejunal mucosa

1991 • 119 citations

Persistent diarrhoea in Zairian AIDS patients: an endoscopic and histological study.

1988 • 116 citations

Activation of the human immunodeficiency virus long terminal repeat by herpes simplex virus type 1 is associated with induction of a nuclear factor that binds to the NF-kappa B/core enhancer sequence

1988 • 111 citations

Quantitative histological study of enteropathy associated with HIV infection.

1990 • 111 citations

Both IgA subclasses are reduced in parotid saliva from patients with AIDS

1991 • 107 citations

Infected cells and immune cells in the gastrointestinal tract of AIDS patients. An immunohistochemical study of 127 cases

1990 • 105 citations

Detection, localization, and quantitation of HIV-associated antigens in intestinal biopsies from patients with HIV.

1991 • 105 citations

Evidence for a cytotoxic T-lymphocyte alveolitis in human immunodeficiency virus-infected patients.

1988 • 96 citations

Cytomegalovirus in the Setting of Infection with Human Immunodeficiency Virus

1990 • 95 citations

Intestinal plasma cell alterations in acquired immunodeficiency syndrome

1987 • 94 citations

An antigenic peptide of the HIV‐1 NEF protein recognized by cytotoxic T lymphocytes of seropositive individuals in association with different HLA‐B

1989 • 91 citations

Regulation of IgA differentiation in CH12LX B cells by lymphokines. IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces membrane IgA-positive CH12LX cells to secrete IgA.

1988 • 91 citations

Duodenal mucosal T cell subpopulation and bacterial cultures in acquired immune deficiency syndrome.

1987 • 86 citations

Histopathologic Findings of Duodenal Biopsy Specimens in HIV-infected Patients With and Without Diarrhea and Malabsorption

1992 • 83 citations

Downregulation of cell surface molecules during noncytopathic infection of T cells with human immunodeficiency virus

1987 • 82 citations

Increased levels of interferon-gamma (IFN-γ), IL-4 and transforming growth factor-beta (TGF-β) mRNA expressing blood mononuclear cells in human HIV infection

1994 • 80 citations

Perspectives on Gastrointestinal Infections in AIDS

1988 • 79 citations

Intestinal Mucosal Immunoglobulins during Human Immunodeficiency Virus Type 1 Infection

1994 • 76 citations

Analysis of Intestinal Lymphocyte Subpopulations in Patients with Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1987 • 69 citations

Rectal mucosal pathology varies with human immunodeficiency virus antigen content and disease stage

1992 • 67 citations

Cytokine gene expression in HIV-infected intestinal mucosa

1994 • 62 citations

Abnormalities in subset distribution, activation, and differentiation of T ceils isolated from large intestine biopsies in HIV infection

1994 • 61 citations

Quantitative analysis of mononuclear cells expressing human immunodeficiency virus type 1 RNA in esophageal mucosa.

1994 • 60 citations

IgA subclasses in HIV disease: dichotomy between raised levels in serum and decreased secretion rates in saliva.

1995 • 60 citations

Advances in experimental medicine and biology

1996 • 57 citations

Mucosal Atrophy Is Associated with Loss of Activated T Cells in the Duodenal Mucosa of Human Immunodeficiency Virus (HΙV)-Infected Patients

1990 • 55 citations

Secretory IgA Antibodies to Cryptosporidium parvum in AIDS patients with Chronic Cryptosporidiosis

1994 • 51 citations

Effects of zidovudine treatment on the small intestinal mucosa in patients infected with the human immunodeficiency virus

1992 • 48 citations

Differences in cytokine secretion by intestinal mononuclear cells, peripheral blood monocytes and alveolar macrophages from HIV-infected patients

1993 • 47 citations

Predominance of helper-inducer T cells in mesenteric lymph nodes and intestinal lamina propria of normal nonhuman primates

1987 • 47 citations

Stool Viruses, Coinfections, and Diarrhea in HIV-Infected Patients

1996 • 45 citations

Direct in vitro infection of human intestine with HIV-1

1992 • 45 citations

Intraepithelial gamma/delta T cells in duodenal mucosa are related to the immune state and survival time in AIDS

1996 • 44 citations

Activation of lamina propria T cells induces crypt epithelial proliferation and goblet cell depletion in cultured human fetal colon.

1992 • 40 citations

Mucosal macrophage subsets of the gut in HIV: decrease in antigen-presenting cell phenotype

1993 • 39 citations

Phenotype and function of lamina propria T lymphocytes

1991 • 38 citations

Human immunodeficiency virus-induced enteropathy

1991 • 35 citations

Detection of rectal antibodies to HIV-1 by a sensitive chemiluminescent western blot immunodetection method.

1994 • 35 citations

The expression of Fc receptors for immunoglobulin G in human rectal epithelium

1991 • 35 citations

Equivalent recognition of HIV proteins, Env, Gag and Pol, by CD4 + and CD8 + cytotoxic T-Iymphocytes

1992 • 35 citations

Virus-specific antibody production and polyclonal B-cell activation in the intestinal mucosa of HIV-infected individuals

1995 • 34 citations

HIV infection of human fetal intestinal explant cultures induces epithelial cell proliferation

1994 • 33 citations

Preferential activation of CD4 T lymphocytes in the lamina propria of gluten-sensitive enteropathy.

1988 • 33 citations

Intestinal Secretory IgA Immune Response against Human Immunodeficiency Virus among Infected Patients with Acute and Chronic Diarrhea

1994 • 30 citations

Cell Differentiation and Proliferation in the Gastrointestinal Tract with Respect to the Local Immune System^a

1994 • 29 citations

Gastrointestinale Befunde bei der HIV-Infektion: Klinik, mikrobiologische Befunde und endoskopisches Erscheinungsbild

2008 • 28 citations

Secretory and serum IgA are inversely altered in AIDS patients

1990 • 28 citations

Detection and localization of HIV RNA and TNF mRNA in rectal biopsies from patients with AIDS

1993 • 18 citations

Functional properties of human lamina propria T lymphocytes assessed with mitogenic monoclonal antibodies

1991 • 17 citations

Intestinal Lymphocyte Populations and Mechanisms of Cell-Mediated Immunity

1988 • 17 citations

Differential expression of tumor necrosis factor alpha and interleukin 1 beta compared with interleukin 6 in monocytes from human immunodeficiency virus-positive individuals measured by polymerase chain reaction.

1994 • 16 citations

Shigella in HIV infection

1991 • 15 citations

Gut immunology

1990 • 12 citations

Expression ofnef, vpu, CA and CD4 during the infection of lymphoid and monocytic cell lines with HIV-1

1992 • 11 citations

HIV-associated Enteropathy

1989 • 7 citations

Loss of activated CD4-positive T cells and increase in activated cytotoxic CD8-positive T cells in the duodenum of patients infected with human immunodeficiency virus. Berlin Diarrhea/Wasting Syndrome Study Group.

1995 • 6 citations