Milestones in the treatment of gout

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

1967 • 1,210 citations

Hyperuricemia in Primary and Renal Hypertension

1966 • 506 citations

A Specific and Reasonably Accurate Method for Routine Determination of Plasma Triglyceride

1960 • 335 citations

Metabolic studies of allopurinol, an inhibitor of xanthine oxidase

1966 • 327 citations

Uric acid nephrolithiasis

1968 • 324 citations

Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase

1963 • 305 citations

The Biochemical Events of Mitosis. II. The in Vivo and in Vitro Binding of Colchicine in Grasshopper Embryos and Its Possible Relation to Inhibition of Mitosis^*

1967 • 291 citations

ACUTE ARTHRITIS IN MAN AND DOG AFTER INTRASYNOVIAL INJECTION OF SODIUM URATE CRYSTALS

1962 • 265 citations

Clinical survey of 354 patients with gout.

1970 • 241 citations

Effect of allopurinol (4-Hydroxypyrazolo-(3,4-d)pyrimidine) on serum and urinary uric acid in primary and secondary gout

1964 • 228 citations

Clinical Science

1962 • 225 citations

Lead in dringking water.

1967 • 219 citations

Renal clearance of oxipurinol, the chief metabolite of allopurinol

1968 • 201 citations

Factors affecting urate excretion following diuretic administration in man

1969 • 183 citations

Xanthine Nephropathy in a Patient with Lymphosarcoma Treated with Allopurinol

1970 • 177 citations

Colchicine plasma levels

1970 • 166 citations

Urinary Xanthine Stones-a Rare Complication of Allopurinol Therapy

1969 • 165 citations

TUBULAR SECRETION OF URATE IN MAN*

1959 • 159 citations

Effects of a xanthine oxidase inhibitor on thiopurine metabolism, hyperuricemia and gout

2001 • 158 citations

Direct Evidence for a Colchicine-Induced Impairment in the Mobility of Membrane Components

1973 • 149 citations

Colchicine: a common mechanism for its anti‐inflammatory and anti‐mitotic effects

1968 • 140 citations

THE RENAL MECHANISM FOR URATE EXCRETION IN MAN 1

1950 • 137 citations

Prevention of Hyperuricemia in Leukemia and Lymphoma

1965 • 134 citations

Use of Allopurinol for Prevention and Control of Hyperuricemia in Patients with Neoplastic Disease

1966 • 132 citations

History of the Use of Colchicum and related Medicaments in Gout: With Suggestions for Further Research

1954 • 111 citations

A three-component system for regulation of renal excretion of uric acid in man.

1961 • 108 citations

Paradoxical Retention of Uric Acid by Uricosuric Drugs in Low Dosage.

1955 • 106 citations

The physiological disposition of probenecid, including renal clearance, in man, studied by an improved method for its estimation in biological material.

1963 • 98 citations

Hyperuricemia in Hyperparathyroidism

1961 • 95 citations

PHENYLBUTAZONE (BUTAZOLIDIN®) IN RHEUMATOID ARTHRITIS AND GOUT

1952 • 91 citations

Some observations on 520 gouty patients

1955 • 91 citations

Severe Hypersensitivity Reactions Associated With Allopurinol

1971 • 87 citations

Effects of adrenocorticotropic hormone (ACTH) in gout

1950 • 84 citations

A potent new uricosuric agent, the sulfoxide metabolite of the phenylbutazone analogue, G-25671.

1957 • 84 citations

Toxic Epidermal Necrolysis, Azotemia, and Death After Allopurinol Therapy

1970 • 82 citations

Mobilization and extracellular release of granular enzymes from human leukocytes during phagocytosis: inhibition by colchicine and cortisol but not by salicylate

1973 • 81 citations

Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone

1954 • 81 citations

Current principles of management in gout

1952 • 70 citations

Hyperuricemia in Diabetic Ketoacidosis

1962 • 69 citations

PROBENECID (BENEMID)

1955 • 65 citations

Granulomatous Hepatitis in a Patient Receiving Allopurinol

1972 • 64 citations

MUTUAL SUPPRESSION OF THE URICOSURIC EFFECTS OF SULFINPYRAZONE AND SALICYLATE: A STUDY IN INTERACTIONS BETWEEN DRUGS*

1963 • 63 citations

THE CLINICAL DETECTION OF THE GENETIC CARRIERS OF INHERITED DISEASE

1947 • 62 citations

Urinary Metabolites in Congenital Hyperuricosuria

1967 • 62 citations

Hyperuricemia Due to Ethambutol

1972 • 61 citations

BIOCHEMICAL PHARMACOLOGICAL CONSIDERATIONS OF PHENYLBUTAZONE AND ITS ANALOGUES

1960 • 60 citations

Xanthine stone formation

1968 • 60 citations

A study of the inverse relationship between pKa and rate of renal excretion of phenylbutazone analogs in man and dog

1960 • 58 citations

THE INFLUENCE OF A NEW BENZOIC ACID DERIVATIVE ON THE METABOLISM OF PARA-AMINOSALICYLIC ACID (PAS) AND PENICILLIN

1950 • 58 citations

HYPERURICEMIA IN MYXEDEMA*

1960 • 55 citations

Secondary gout associated with myeloproliferative diseases

1965 • 54 citations

THERAPEUTIC VALUE OF PROBENECID (BENEMID®) IN GOUT

1952 • 53 citations

Clinical Significance of Hyperuricemia in Routinely Screened Hospitalized Men

1970 • 51 citations

Ultrastructural Changes in Skeletal Muscle Induced by Colchicine

1971 • 50 citations

Benemid (p-di-n-propylsulfamyl)-benzoic acid) as uricosuric agent in chronic gouty arthritis.

1951 • 48 citations

PROTRACTED URICOSURIC THERAPY IN TOPHACEOUS GOUT*1

1957 • 47 citations

PRINCIPLES OF CURRENT MANAGEMENT OF PRIMARY GOUT

1967 • 43 citations

Aplastic agranulocytosis after allopurinol therapy

1972 • 42 citations

EFFECT OF PHENYLBUTAZONE (3,5 DIOXO-1,2-DIPHENYL-4-n-BUTYLPYRAZOLIDINE) ON RENAL CLEARANCE OF URATE AND OTHER DISCRETE RENAL FUNCTIONS IN GOUTY SUBJECTS 1

1953 • 41 citations

Colchicine

1961 • 40 citations

Metabolites of probenecid. Chemical, physical, and pharmacological studies

1972 • 39 citations

METABOLIC STUDIES ON PATIENTS WITH GOUT

1938 • 38 citations

Effect of Some Drugs on Clinical Laboratory Values as Determined by the Technicon SMA 12/60

1972 • 37 citations

Evaluation of Uricosuric Agents in Chronic Gout

1957 • 37 citations

"Studies on the Nature of Gouty Tophi" by Max Freudweiler, 1899

1964 • 35 citations

Mobilization of gouty tophi by protracted use of uricosuric agents

1951 • 35 citations

Results of a clinical trial of g‐28315, a sulfoxide analog of phenylbutazone, as a uricosuric agent in gouty subjects

1958 • 34 citations

Microscopic Studies on Skeletal Muscle in Gout Patients Treated with Allopurinol

1971 • 33 citations

Some recent advances in the study of uric acid metabolism and gout.

1951 • 32 citations

FURTHER EXPERIENCES OF TOXIC EPIDERMAL NECROLYSIS INCRIMINATING ALLOPURINOL, PYRAZOLONE AND DERIVATIVES

1972 • 32 citations

Gout and Hyperuricemia after Adrenalectomy for Hypertension

1963 • 31 citations

Fatal Massive Necrosis of the Liver as a Manifestation of Hypersensitivity to Probenecid

1957 • 31 citations

Nephrotic Syndrome Caused by Probenecid

1961 • 31 citations

The clinical and metabolic effects of Benemid in patients with gout

2001 • 30 citations

The occurrence of hyperuricemia during pyrazinamide-isoniazid therapy.

1956 • 30 citations

Studies of interactions among drugs in man at the renal level: Probenecid and sulfinpyrazone

1969 • 30 citations

Hageman Factor and Acute Gouty Arthritis

1968 • 29 citations

Hyperuricemia, a Concomitant of Congenital Vasopressin-Resistant Diabetes Insipidus in the Adult

1971 • 29 citations

Metabolism of sulfinpyrazone (Anturane) and other thio analogues of phenylbutazone in man.

1961 • 28 citations

Observations on Dissolution of Uric Acid Calculi

1965 • 28 citations

Hereditary factors in gout; a review of recent literature.

1957 • 27 citations

Transport and excretion of uric acid in man. III. Physiologic significance of the uricosuric effect of caronamide

1948 • 27 citations

Hyperuricemia in hypoparathyroidism.

1956 • 26 citations

Observations on the Disposition of Probenecid in Patients Receiving Allopurinol

1972 • 25 citations

Gout While Receiving Levodopa for Parkinsonism

1972 • 21 citations

GOUT

1936 • 20 citations

USE OF THE NEWER URICOSURIC AGENTS IN THE MANAGEMENT OF GOUT

1960 • 17 citations

Allopurinol and Xanthine Nephropathy

1970 • 16 citations

A Method for Measuring Swelling of Hands and Feet Part II: Influence of New Anti-Inflammatory Drug, Indomethacin, in Acute Gout

1963 • 13 citations

CURRENT STATUS OF THE TREATMENT OF GOUT

1957 • 13 citations

The biological significance of uric acid.

1966 • 12 citations

A view of gout as inborn error of metabolism

1960 • 11 citations

[Hereditary factors in gout].

1958 • 11 citations

THE USE OF THE XANTHINE OXIDASE INHIBITOR, ALLOPURINOL, IN THE CONTROL OF HYPERURICÆMIA, GOUT AND URIC ACID CALCULI

1967 • 10 citations

Gout And Gouty Arthritis

1959 • 6 citations

Deleted Work

1955 • 0 citations