Mind over metabolism: The cephalic phase in relation to non-insulin-dependent diabetes and obesity☆

Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes

1986 • 1,275 citations

Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man

1981 • 1,168 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Neural control of the endocrine pancreas.

1974 • 630 citations

An autoradiographic study of the efferent connections of the lateral hypothalamic area in the rat

1979 • 505 citations

Fasting, Feeding and Regulation of the Sympathetic Nervous System

1978 • 498 citations

Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes

1985 • 461 citations

Plasma Insulin Responses to Glucose and Tolbutamide of Normal Weight and Obese Diabetic and Nondiabetic Subjects

1966 • 338 citations

Pancreatic Neuroendocrinology: Peripheral Neural Mechanisms in the Regulation of the Islets of Langerhans*

1981 • 313 citations

AFFERENT IMPULSE DISCHARGES FROM GLUCORECEPTORS IN THE LIVER OF THE GUINEA PIG

1969 • 303 citations

ADVANCES IN METABOLIC DISORDERS

1965 • 302 citations

Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels

1971 • 291 citations

The glucose paradox. Is glucose a substrate for liver metabolism?

1984 • 273 citations

Acute Hyperinsulinemia and Its Reversal by Vagotomy after Lesions of the Ventromedial Hypothalamus in Anesthetized Rats*

1979 • 266 citations

Measurement of total and organ-specific norepinephrine kinetics in humans

1984 • 265 citations

Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion

1986 • 265 citations

Central nervous system regulation of liver and adipose tissue metabolism

1981 • 256 citations

Reciprocal Influences of the Ventromedial and Lateral Hypothalamic Nuclei on Blood Glucose Level and Liver Glycogen Content

1966 • 236 citations

Cephalic phase, reflex insulin secretion neuroanatomical and physiological characterization

1981 • 231 citations

Neural network of glucose monitoring system

1984 • 230 citations

Enhanced plasma norepinephrine response to upright posture and oral glucose administration in elderly human subjects

1980 • 222 citations

Preabsorptive insulin release and hypoglycemia in rats

1976 • 218 citations

Physiological Importance of Deficiency in Early Prandial Insulin Secretion in Non-Insulin-Dependent Diabetes

1988 • 216 citations

Initial splanchnic extraction of ingested glucose in normal man

1978 • 206 citations

Hepatic nerves: a review of their functions and effects

1980 • 204 citations

Noradrenaline turnover during under- and over-eating in normal weight subjects

1982 • 196 citations

Descending pathways from hypothalamus to dorsal motor vagus and ambiguus nuclei in the rat

1984 • 179 citations

Assessment of Sympathetic Nervous Function in Humans from Noradrenaline Plasma Kinetics

1982 • 171 citations

Hypothalamic obesity

1981 • 169 citations

Glucose as a Regulator of Neuronal Activity

1983 • 167 citations

Functional correlations between lateral hypothalamic glucose-sensitive neurons and hepatic portal glucose-sensitive units in rat

1983 • 165 citations

Sensory functions of the liver--a review

1979 • 164 citations

Insulin Responses in Equivocal and Definite Diabetes, with Special Reference to Subjects Who Had Mild Glucose Intolerance but Later Developed Definite Diabetes

1977 • 156 citations

Importance of Timing of Preprandial Subcutaneous Insulin Administration in the Management of Diabetes Mellitus

1983 • 154 citations

Hypothalamic Monoamine Control of Stress-Induced Adrenocorticotropin Release in the Rat*

1983 • 153 citations

Effects of hypothalamic lesion on pancreatic autonomic nerve activity in the rat

1984 • 153 citations

Effects of hypothalamic stimulation on gluconeogenesis and glycolysis in rat liver

1975 • 153 citations

Relationships between brain noradrenergic activity and blood glucose

1984 • 152 citations

Evidence that insulin resistance is responsible for the decreased thermic effect of glucose in human obesity.

1985 • 152 citations

Neural Regulation of Insulin Secretion in the Dog

1973 • 150 citations

Loss of Early Phase of Insulin Release in Humans Impairs Glucose Tolerance and Blunts Thermic Effect of Glucose

1987 • 146 citations

Glycogen Synthetase Activity in Liver: Regulation by the Autonomic Nerves

1967 • 143 citations

Thermic effect of food at rest, during exercise, and after exercise in lean and obese men of similar body weight.

1985 • 142 citations

Reduced sympathetic nervous system activity in rats with ventromedial hypothalamic lesions

1982 • 139 citations

Increased Activities of Glycogenolytic Enzymes in Liver after Splanchnic-Nerve Stimulation

1965 • 135 citations

Ventromedial Hypothalamic Lesions and the Mobilization of Fatty Acids

1978 • 134 citations

Abnormal oral glucose tolerance in genetically obese (fa/fa) rats

1985 • 124 citations

Nature of Islet-cell Innervation in the Cat Pancreas

1968 • 117 citations

Regulation of glycogen metabolism in liver by the autonomic nervous systemV. Activation of glycogen synthetase by vagal stimulation

1971 • 117 citations

The release of pancreatic glucagon and inhibition of insulin in response to stimulation of the sympathetic innervation.

1975 • 115 citations

Diet and cephalic phase insulin responses

1985 • 112 citations

Cephalic phase metabolic responses in normal weight adults

1987 • 110 citations

Diminished Insulin Response to Hyperglycemia in Prediabetes and Diabetes

1967 • 109 citations

Relationship between two stages of prandial insulin release in rats.

1978 • 107 citations

Evidence for centers in the central nervous system that selectively regulate fat mobilization in the rat

1973 • 102 citations

Neural pathways involved in the hypothalamic integration of autonomic responses

1981 • 102 citations

Comparison of the metabolic and behavioral disturbances following paraventricular- and ventromedial-hypothalamic lesions

1985 • 97 citations

The Hepatic Vagus Nerve and the Neural Regulation of Insulin Secretion*

1985 • 96 citations

Regulation of insulin secretion.

1969 • 95 citations

Reduced postprandial heat production with gavage as compared with meal feeding in human subjects

1984 • 93 citations

Increases in Plasma Insulin Levels in Response to Electrical Stimulation of the Dorsal Motor Nucleus of the Vagus Nerve*

1983 • 89 citations

An hypothesis on the aetiology of obesity: dysfunction of the central nervous system as a primary cause

1985 • 89 citations

Thermic effects of food and exercise in lean and obese men of similar lean body mass

1987 • 88 citations

Intrahypothalamic injection of insulin decreases firing rate of sympathetic nerves.

1987 • 88 citations

Timing of Insulin Delivery with Meals

1981 • 87 citations

Comparison of metabolic alterations in hypothalamic and high fat diet-induced obesity

1977 • 87 citations

Evidence for an insulin-sensitive receptor in the central nervous system

1972 • 85 citations

Cellular basis of direct insulin action in the central nervous system

1981 • 79 citations

Regulation of glycogen metabolism in liver by the autonomic nervous systemIV. Neural control of glycogen biosynthesis

1971 • 75 citations

The hyperglycaemic response to stimulation of the hepatic sympathetic innervation in adrenalectomized cats and dogs

1972 • 73 citations

Gap Junction Development Is Correlated with Insulin Content in the Pancreatic B Cell

1980 • 67 citations

Localization of CNS glucoregulatory insulin receptors within the ventromedial hypothalamus

1975 • 61 citations

Studies on the effects of insulin and acetylcholine on activation of glycogen synthase and on glycogenesis in hepatocytes isolated from normal fed rats

1974 • 59 citations

Effect of Vagotomy on Serum Insulin in Rats with Paraventricular or Ventromedial Hypothalamic Lesions*

1986 • 58 citations

The relative contribution of the nervous system, hormones, and metabolites to the total insulin response during a meal in the rat

1984 • 53 citations

Fiber connections in the hypothalamus and some autonomic functions.

1975 • 53 citations

Mechanism of Abnormal Oral Glucose Tolerance of Genetically Obese fa/fa Rats

1986 • 53 citations

Preganglionic innervation of the pancreas islet cells in the rat

1984 • 52 citations

Rapid Bidirectional Effects of Insulin on Hypothalamic Noradrenergic and Serotoninergic Neuronal Activity in the Rat: Role in Glucose Homeostasis*

1985 • 52 citations

Time Dependence of Insulin Action in Muscle and Adipose Tissue in the Rat In Vivo: An Increasing Response in Adipose Tissue with Time

1985 • 51 citations

Serotoninergic Control of Growth Hormone Secretion: Hypothalamic Dopamine, Norepinephrine, and Serotonin Levels and Metabolism in Three Hyposomatotropic Rat Models and in Normal Rats*

1982 • 50 citations

Blood glucose levels modulate efferent activity in the vagal supply to the rat liver.

1985 • 49 citations

Meal-induced increases in parasympathetic and sympathetic activity elicit simultaneous rises in plasma insulin and free fatty acids

1986 • 49 citations

Decrease in plasma glucose concentration after microinjection of insulin into VMN

1981 • 47 citations

Organization and function of the sympathetic innervation.

1977 • 47 citations

Central action of glucagon in rat hypothalamus

1986 • 46 citations

Hypothalamic control of liver glycogen metabolism in adult and aged rats

1978 • 45 citations

In Vitro Autoregulation of Glucose Utilization in Rat Soleus Muscle

1987 • 45 citations

Sympathetic control of hepatic glycogenolysis during glucopenia in man

1975 • 45 citations

Activation of glycogenolysis and norepinephrine overflow in the perfused rat liver during repetitive perivascular nerve stimulation

1982 • 43 citations

Guanethidine blocks the 2-deoxy-d-glucose-induced hypothalamic noradrenergic drive to hyperglycemia

1985 • 39 citations

Neuronal control of intermediate metabolism

1986 • 39 citations

Neural inhibition of insulin secretion from the isolated canine pancreas

1975 • 38 citations

Chemical coding of the hypothalamic neurones in metabolic control. II. Norepinephrine-sensitive neurones and glycogen breakdown in liver

1980 • 36 citations

Ventromedial and dorsomedial hypothalamic syndromes in the weanling rat: Is the “center” concept really outmoded?

1985 • 36 citations

Anorexic Effect of Intraperitoneal Glucose in the Hypothalamic Hyperphagic Cat

1963 • 34 citations

Intraportal Islet Transplantation: Functional Assessment in Conscious Unrestrained Rats*

1980 • 34 citations

Role of the autonomic nervous system in the development of ventromedial hypothalamic obesity

1980 • 31 citations

Adrenergic regulation of lipolysis and insulin secretion in the fasted baboon

1973 • 30 citations

The role of the ventromedial hypothalamic area in periprandial glucoregulation

1985 • 29 citations

CNS Regulation of Glucagon Secretion

1983 • 26 citations

Pancreatic endocrine responses to stimulation of the peripheral ends of the splanchnic nerves in the conscious adrenalectomized calf.

1980 • 25 citations

Decreased plasma epinephrine concentrations after glucose ingestion in humans

1984 • 24 citations

Hyperglycaemia: Imitating Claude Bernard's Piqûre with drugs

1985 • 24 citations

Peptides in metabolic autonomic nerves

1981 • 24 citations

The ventromedial hypothalamic area and the vagus are neural substrates for anticipatory insulin release

1985 • 24 citations

Chemical coding of the hypothalamic neurones in metabolic control. I. Acetylcholine-sensitive neurones and glycogen synthesis in liver

1979 • 23 citations

Effect of Acetylcholine on Glycogen Formation and the Activity of Glycogen Synthetase in Isolated, Perfused Rat Liver

1971 • 23 citations

Pavlovian conditioning of the cephalic phase of gastric acid secretion in the rat

1981 • 21 citations

Pancreatic nerve response induced by hypothalamic stimulation in rats

1980 • 18 citations

Pre- and postabsorptive insulin secretion in chronic decerebrate rats

1986 • 16 citations

CNS - endocrine pancreas system. IV. Evidence for the existence of a direct hypothalamic-vagal descending pathway.

1978 • 13 citations

VMH Procainization abolishes cephalic phase insulin response

1980 • 11 citations

Development of hypoglycemia and hyperglycemia as a function of number of trials in insulin conditioning☆

1985 • 7 citations