Tumor Cell and Endothelial Cell Therapy of Oral Cancer by Dual Tyrosine Kinase Receptor Blockade

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections.

1991 • 2,598 citations

Generalized, Linear, and Mixed Models

2001 • 2,425 citations

Head and Neck Cancer

1993 • 2,263 citations

Gefitinib in Combination With Gemcitabine and Cisplatin in Advanced Non–Small-Cell Lung Cancer: A Phase III Trial—INTACT 1

2004 • 1,733 citations

Gefitinib in Combination With Paclitaxel and Carboplatin in Advanced Non–Small-Cell Lung Cancer: A Phase III Trial—INTACT 2

2004 • 1,723 citations

Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer

2003 • 1,248 citations

Phase I and Pharmacologic Study of OSI-774, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced Solid Malignancies

2001 • 995 citations

A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.

2001 • 988 citations

Vascular permeability factor (VPF, VEGF) in tumor biology

1993 • 839 citations

Multicenter Phase II Study of Erlotinib, an Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck

2003 • 803 citations

EGF receptor

1999 • 792 citations

Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase.

2000 • 766 citations

Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck.

1999 • 707 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.

1993 • 645 citations

Phase II Trial of ZD1839 in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

2003 • 616 citations

Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis.

2001 • 545 citations

Cancer statistics, 1992

1992 • 540 citations

Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.

2000 • 505 citations

Phase I Study of Anti–Epidermal Growth Factor Receptor Antibody Cetuximab in Combination With Radiation Therapy in Patients With Advanced Head and Neck Cancer

2001 • 479 citations

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells

2003 • 439 citations

Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts.

1993 • 430 citations

Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice.

1999 • 419 citations

The role of vascular endothelial growth factor in pathological angiogenesis

1995 • 419 citations

Expression of Angiogenesis-Related Genes and Progression of Human Ovarian Carcinomas in Nude Mice

1998 • 377 citations

Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells.

2000 • 376 citations

Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells.

1995 • 317 citations

Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma.

1997 • 305 citations

Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors

2001 • 232 citations

Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers.

2000 • 220 citations

Reciprocal paracrine interactions between tumour cells and endothelial cells: the ‘angiogenesis progression’ hypothesis

1996 • 212 citations

Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation

2001 • 202 citations

ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression

2001 • 194 citations

ZD1839 (‘Iressa’), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model

2002 • 175 citations

An orthotopic nude mouse model of oral tongue squamous cell carcinoma.

2002 • 174 citations

CI-1033, a pan-erbB tyrosine kinase inhibitor

2001 • 160 citations

Pharmacological Evaluation of Humanized Anti-Epidermal Growth Factor Receptor, Monoclonal Antibody h-R3, in Patients With Advanced Epithelial-Derived Cancer

2003 • 110 citations

Targeting Epidermal Growth Factor Receptor in Head and Neck Cancer

2022 • 94 citations

Expression of Growth Factors and Growth Factor Receptors in Capillary Hemangioblastoma

1996 • 92 citations

Clinical trial with escalating doses of the antiepidermal growth factor receptor humanized monoclonal antibody EMD 72 000 in patients with advanced squamous cell carcinoma of the larynx and hypopharynx

2001 • 77 citations

IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer

2002 • 70 citations

The role of epidermal growth factor receptor in head and neck squamous cell carcinoma

2003 • 66 citations

IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer

2002 • 64 citations

Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer

2003 • 43 citations

Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer.

2003 • 41 citations