An orthotopic nude mouse model of oral tongue squamous cell carcinoma.

Global cancer statistics

2011 • 55,498 citations

Cancer Statistics, 2001

2001 • 3,342 citations

Selection of Successive Tumour Lines for Metastasis

1973 • 1,360 citations

The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity

1990 • 547 citations

Frequency and therapeutic implications of “skip metastases” in the neck from squamous carcinoma of the oral tongue

1997 • 464 citations

Orthotopic models are necessary to predict therapy of transplantable tumors in mice.

1998 • 417 citations

Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis

1986 • 382 citations

The Extracapsular Spread of Tumors in Cervical Node Metastasis

1981 • 370 citations

Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?

1998 • 305 citations

Elective neck dissection versus observation in the treatment of early oral tongue carcinoma

1997 • 280 citations

Specificity of arrest, survival, and growth of selected metastatic variant cell lines.

1978 • 203 citations

A New Immunocompetent Murine Model for Oral Cancer

1997 • 139 citations

T1 and T2 squamous cell carcinoma of the oral tongue: Prognostic factors and the role of elective lymph node dissection

1999 • 134 citations

Orthotopic implantation is essential for the selection, growth and metastasis of human real cell cancer in nude mice

1990 • 101 citations

Orthotopic is orthodox: Why are orthotopic‐transplant metastatic models different from all other models?

1994 • 91 citations

Experience of the curie institute in treatment of cancer of the mobile tongue. II. Management of the neck nodes

1981 • 80 citations

Head and Neck Cancers

2005 • 78 citations

The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1a, IL-6, GM-CSF, and KC

1998 • 76 citations

Development of a new in vivo model for head and neck cancer

1990 • 62 citations

Murine Colon Adenocarcinoma: Syngeneic Orthotopic Transplantation and Subsequent Hepatic Metastases2

1977 • 54 citations

Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction.

1997 • 52 citations

An orthotopic floor‐of‐mouth cancer model allows quantification of tumor invasion

1998 • 36 citations