Ultrastructural localization of butyrylcholinesterase in senile plaques in the brains of aged and Alzheimer disease patients

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Senile dementia of the Alzheimer type

1983 • 835 citations

The Molecular Forms of Cholinesterase and Acetylcholinesterase in Vertebrates

1982 • 819 citations

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

1991 • 531 citations

Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids.

1987 • 469 citations

Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis.

1995 • 418 citations

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

1988 • 410 citations

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by? protein immunostaining

1988 • 280 citations

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

1991 • 276 citations

Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals

1988 • 270 citations

Diffuse type of senile plaques in the brains of Alzheimer-type dementia

1988 • 218 citations

Acetylcholinesterase may have novel functions in the brain

1984 • 216 citations

Alzheimer .beta.-Amyloid Peptide 25-35: Electrostatic Interactions with Phospholipid Membranes

1994 • 171 citations

Anatomy of cholinesterase inhibition in Alzheimer's disease: Effect of physostigmine and tetrahydroaminoacridine on plaques and tangles

1987 • 171 citations

Colocalization of cholinesterases with ? amyloid protein in aged and Alzheimer's brains

1993 • 167 citations

pH‐Dependent Binding of Synthetic β‐Amyloid Peptides to Glycosaminoglycans

1993 • 140 citations

Electron micrograph of diffuse plaques. Initial stage of senile plaque formation in the Alzheimer brain.

1989 • 140 citations

Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease.

1992 • 138 citations

ENZYME HISTOCHEMICAL STUDIES OF SENILE PLAQUES

1965 • 127 citations

Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease

1987 • 126 citations

Secreted acetylcholinesterase: non-classical aspects of a classical enzyme

1992 • 105 citations

Deposition of ?/A4 protein along neuronal plasma membranes in diffuse senile plaques

1991 • 105 citations

Senile plaques: staining for acetylcholinesterase and A4 protein: a comparative study in the hippocampus and entorhinal cortex

1990 • 103 citations

Amyloid β protein-induced neuronal cell death: neurotoxic properties of aggregated amyloid β protein

1994 • 102 citations

Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease

1989 • 90 citations

EARLY SENILE PLAQUES IN DOWN'S SYNDROME BRAINS SHOW A CLOSE RELATIONSHIP WITH CELL BODIES OF NEURONS

1989 • 84 citations

Protease inhibitors and indoleamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease.

1993 • 70 citations

Immunoelectron microscopic localization of amyloid β protein in the diffuse plaques of Alzheimer-type dementia

1990 • 69 citations

Ultrastructural localization of Alzheimer amyloid ?/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes

1992 • 53 citations

A comparative histochemical mapping of the distribution of butyryl cholinesterase in the brains of four species of mammals, including man

1967 • 52 citations

Neurons segregate clusters of membrane-bound acetylcholinesterase along their neurites.

1987 • 51 citations

Senile plaque-like structures: observation of a probably unknown type of senile plaque by periodic-acid methenamine silver (PAM) electron microscopy

1989 • 46 citations

Early senile plaques in Alzheimer's disease demonstrated by histochemistry, immunocytochemistry, and electron microscopy

1990 • 46 citations

Acetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of Alzheimer's disease

1992 • 40 citations

Ultrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil threads and senile plaques in aged and Alzheimer's brain

1992 • 40 citations

Biochemistry of Alzheimer's disease amyloid plaques

1993 • 37 citations

The genesis of the senile plaque. Further evidence in support of its neuronal origin.

1992 • 34 citations

Plaque-Associated Neuronal Proteins: A Recurrent Motif in Neuritic Amyloid Deposits throughout Diverse Cortical Areas of the Alzheimer's Disease Brain

1994 • 30 citations

Morphological study of amyloid fibrils and preamyloid deposits in the brain with Alzheimer's disease

1992 • 28 citations

Ultrastructural Characterization of Cerebellar Diffuse Plaques in Alzheimer's Disease

1992 • 26 citations

Ultrastructural heterogeneity in cerebral amyloid of Alzheimer's disease

1988 • 23 citations

Ultrastructural localization of argyrophilic substances in diffuse plaques of Alzheimer-type dementia demonstrated by methenamine silver staining

1991 • 17 citations

Relationship between non-fibrillary amyloid precursors and cell processes in the cortical neuropil of Alzheimer patients

1991 • 15 citations

Occurrence of acetylcholinesterase activity closely associated with amyloid ?/A4 protein is not correlated with acetylcholinesterase-positive fiber density in amygdala of Alzheimer's disease

1992 • 15 citations