Angiotensin‐converting enzyme inhibitors: Medicinal chemistry and biological actions

Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung

1971 • 2,569 citations

Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive Agents

1977 • 1,851 citations

Renin-angiotensin system: biochemistry and mechanisms of action.

1977 • 1,373 citations

Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids

1977 • 900 citations

Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.

1980 • 731 citations

A new class of angiotensin-converting enzyme inhibitors

1980 • 704 citations

A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin

1970 • 533 citations

Angiotensin-Converting Enzyme and the Regulation of Vasoactive Peptides

1976 • 457 citations

An Angiotensin Converting-Enzyme Inhibitor to Identify and Treat Vasoconstrictor and Volume Factors in Hypertensive Patients

1974 • 349 citations

The Conformation of Thermolysin

1974 • 332 citations

A SPECIFIC ORALLY ACTIVE INHIBITOR OF ANGIOTENSIN-CONVERTING ENZYME IN MAN

1977 • 332 citations

Captopril

1980 • 315 citations

Crystallographic study of the binding of dipeptide inhibitors to thermolysin: implications for the mechanism of catalysis

1977 • 240 citations

A crystallographic study of the complex of phosphoramidon with thermolysin. A model for the presumed catalytic transition state and for the binding of extended substrates

1977 • 218 citations

SQ 14,225 (D-3-mercapto-2-methylpropanoyl-l-proline), a novel orally active inhibitor of angiotensin I-converting enzyme.

1978 • 209 citations

Biochemical regulation of blood pressure

1981 • 201 citations

Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A

1973 • 193 citations

Design of potent reversible inhibitors for thermolysin. Peptides containing zinc coordinating ligands and their use in affinity chromatography

1979 • 151 citations

Inhibition of Pressor Effects of Angiotensin I and Augmentation of Depressor Effects of Bradykinin by Synthetic Peptides

1972 • 146 citations

Effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro and its ethyl ester (MK-421) on angiotensin converting enzyme in vitro and angiotensin I pressor responses in vivo.

1981 • 146 citations

Inhibition of thermolysin and carboxypeptidase A by phosphoramidates

1979 • 138 citations

Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects.

1981 • 124 citations

Structure of carboxypeptidase B at 2.8 Å resolution

1976 • 121 citations

Antihypertensive activity of N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro (MK-421), an orally active converting enzyme inhibitor.

1981 • 119 citations

Design of potent and specific inhibitors of carboxypeptidases A and B

1979 • 117 citations

Peptide hydroxamic acids as inhibitors of thermolysin

1978 • 116 citations

Inhibitors of angiotensin-converting enzyme for treatment of hypertension

1980 • 116 citations

New Substrates for the Radioassay of Angiotensin Converting Enzyme of Endothelial Cells in Culture

1978 • 105 citations

Synthesis and biological activity of a ketomethylene analog of a tripeptide inhibitor of angiotensin converting enzyme

1980 • 93 citations

Purification and substrate specificity of bovine angiotensin-converting enzyme.

1981 • 89 citations

REDUCTION OF PRESSOR EFFECTS OF ANGIOTENSIN I IN MAN BY SYNTHETIC NONAPEPTIDE (B.P.P.9a OR SQ 20,881) WHICH INHIBITS CONVERTING ENZYME

1973 • 85 citations

Studies on inhibitory effect of phosphoramidon and its analogs on thermolysin

1975 • 84 citations

Functional residues at the active site of angiotensin converting enzyme

1978 • 82 citations

Metal-coordinating substrate analogs as inhibitors of metalloenzymes.

1979 • 81 citations

On double bond isosters of the peptide bond; an enkephalin analogue

1980 • 75 citations

Structure-reactivity correlation for the hydrolysis of phosphoramidate monoanions

1971 • 72 citations

Angiotensin converting enzyme inhibitors

1982 • 71 citations

Effects of Captopril in Animal Models of Hypertension

1980 • 68 citations

Relationship of the three dimensional structure of carboxypeptidase A to catalysis

1974 • 64 citations

Evidence for prejunctional inhibition of norepinephrine release by captopril in spontaneously hypertensive rats

1980 • 62 citations

Use of First-Dose Response or Plasma Renin Activity to Predict the Long-Term Effect of Captopril

1980 • 54 citations

1 The Hydrolysis of Sulfate Esters

1971 • 52 citations

Synthesis of 2-phosphonopyrrolidine and its substitution for proline in an inhibitor of angiotensin-converting enzyme

1979 • 42 citations

Progress in Medicinal Chemistry

1963 • 40 citations

Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(mercaptomethyl)-2-oxo-1-piperidineacetic acids

1981 • 35 citations

Inhibition of angiotensin converting enzyme with Nα-phosphoryl-L-alanyl-L-proline and Nα-phosphoryl-L-valyl-L-tryptophan

1980 • 27 citations

Antihypertensive Effects of the Novel Converting-Enzyme Inhibitor YS 980 in Spontaneously Hypertensive Rats

1981 • 10 citations

Effects of N-Mercaptoacylamino Acids on Inhibition of Angiotensin I Converting Enzyme

1978 • 10 citations

ANGIOTENSIN CONVERTING ENZYME INHIBITORS

1981 • 9 citations

Synthesis of peptides containing N-2-aminoethylglycine—‘reduction analogues’

1971 • 9 citations

MK-421: A new oral angiotensin converting enzyme inhibitor for essential hypertension

1981 • 8 citations

Peptide-gap inhibitors: I. Competitive inhibition of aminopeptidase M by a hydrolytically resistant dipeptide analogue of glycylleucine

1977 • 6 citations

Angiotensin-Converting Enzyme Inhibitors

2003 • 6 citations

The Renin System in High Blood Pressure, from Disbelief to Reality

1980 • 6 citations

Pharmacological studies on SA446, a new angiotensin I-converting enzyme inhibitor.

1980 • 4 citations

Synthesis of carbocyclic analogs of captopril (SQ-14225).

1979 • 3 citations

Captopril (Capoten®; SQ 14,225) (d-3-Mercapto-2-methylpropanoyl-l-proline)

1980 • 3 citations